banner
lbastianmd.bsky.social
Lorenz Bastian
@lbastianmd.bsky.social
76 followers 160 following 11 posts
translational leukemia research // ALL 🧬 disease classification // crossroads of B cell development and leukemogenesis // Co-Head of Functional Genomics of Acute Leukemia Lab @ UKSH, Kiel 🌊, Germany and PI @ catchall-kfo5010.com // mountain 🥾 enthusiast
Posts Media Videos Starter Packs
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
Big shoutout to the whole group who made #IntegrateALL possible - especially @alinamh.bsky.social, Thomas Beder and Claudia Baldus at www.catchall-kfo5010.com
2 2
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
Big shoutout to the whole group who made #IntegrateALL possible - especially @alinamh.bsky.social, Thomas Beder and Claudia Baldus at www.catchall-kfo5010.com
CATCH ALL KFO 5010
Within the new Clinical Research Unit (CRU) “CATCH ALL – towards a cure for all adults and children with Acute Lymphoblastic Leukemia (ALL)”, funded by the German Research Foundation (DFG)…
www.catchall-kfo5010.com
1
Reposted by Lorenz Bastian
biorxiv-cancer.bsky.social
bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 11d
IntegrateALL: an end-to-end RNA-seq analysis pipeline for multilevel data extraction and interpretable subtype classification in B-precursor ALL https://www.biorxiv.org/content/10.1101/2025.09.25.673987v1
1 2
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
🔗 Get the pipeline here:
github.com/NadineWolgas...
We welcome your feedback, issues & pull requests — and are happy to help you get started!🚀
#OpenSource #Bioinformatics #AcuteLymphoblasticLeukemia
GitHub - NadineWolgast/IntegrateALL: Snakemake diagnostic Pipline for B-ALL classification
Snakemake diagnostic Pipline for B-ALL classification - NadineWolgast/IntegrateALL
github.com
1 4
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
In n=31/1210 B-ALL cases (2.6%), #IntegrateALL identified drivers from two different subtypes in one sample! One gene expression signature dominated in most cases, supporting unsupervised screening for drivers.
1 1
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
Analysis with our ICC/WHO-HAEM5 based rule-set yielded ~80% unambiguous subtype definitions based on driver calls and corresponding gene expression signatures, which was validated across independent cohorts. - Many thanks to collaborators @ www.mll.com!
1
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
With #IntegrateALL, we extract from RNA-seq:

- Expression counts
- B-ALL subtypes via #ALLCatchR
- Driver gene fusions
- SNVs
- Virtual karyotypes

For classifying #RNASeqCNV B-ALL karyotypes, we built #KaryALL, a machine-learning classifier reaching 0.98 accuracy!
1
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · 10d
Excited to share our preprint📯:
We introduce #IntegrateALL, an open-source RNA-seq pipeline for interpretable molecular diagnostics in acute lymphoblastic leukemia!🧬
Big thanks to Nadine Wolgast & team @ www.uksh.de
, catchall-kfo5010.com!
See: doi.org/p7k5 and 🧵
1 1 3
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · Aug 7
Finally some larger perspective after a long day on call… 🚀
sagan.bsky.social
Saganism @sagan.bsky.social · Aug 6
"The cosmos is within us. We are made of star-stuff. We are a way for the universe to know itself."
"The cosmos is within us. We are made of star-stuff. We are a way for the universe to know itself."
1
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · Jul 24
What determines Inotuzumab sensitivity in #ALL?
New @bloodjournal.bsky.social study from C. Escherich &
@junjyang.bsky.social Lab highlights the role of B cell developmental state and EBF1. It was a pleasure to provide a commentary!
🔬 doi.org/10.1182/bloo...
🗒️ doi.org/10.1182/bloo...
3
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · Jun 20
@Hemasphere_EHA acknowledged our ALLCatchR paper on machine learning based subtype classification in ALL as highly influential publication! 💥So happy and grateful! Big kudos to Thomas and our team at 👉catchall-kfo5010.com #EHA2025
hemasphere-journal.bsky.social
HemaSphere Journal @hemasphere-journal.bsky.social · Jun 20
At #EHA2025, HemaSphere was honored to award authors of 4 recent + highly influential publications that significantly contribute to the hematology field. Congrats to Thomas Beder & coauthors for their publication about ALLCatchR identifying B-cell precursor ALL subtypes 👉https://bit.ly/409NrHe
1 4
lbastianmd.bsky.social
Lorenz Bastian @lbastianmd.bsky.social · Apr 15
So true!!
nadia-davidson.bsky.social
Nadia Davidson @nadia-davidson.bsky.social · Mar 28
Is there an AI that can rewrite CVs according to the needs of each grant application? Genuinely interested. Imagine how much research we could do if we weren't reformatting CVs constantly.
2