Lee Bardwell
@leebardwell.bsky.social
Scientist, educator, father, concerned citizen. Professor at UC Irvine Dunlop School of Biological Sciences.
Pinned
A preprint of our latest manuscript is out on bioRxiv.
We used AlphaFold3 to predict the structure of the human GLI1-SUFU, GLI2-SUFU and GLI3-SUFU complexes (and fly Ci-Sufu), revealing three novel interfaces.
www.biorxiv.org/content/10.6...
We used AlphaFold3 to predict the structure of the human GLI1-SUFU, GLI2-SUFU and GLI3-SUFU complexes (and fly Ci-Sufu), revealing three novel interfaces.
www.biorxiv.org/content/10.6...
A preprint of our latest manuscript is out on bioRxiv.
We used AlphaFold3 to predict the structure of the human GLI1-SUFU, GLI2-SUFU and GLI3-SUFU complexes (and fly Ci-Sufu), revealing three novel interfaces.
www.biorxiv.org/content/10.6...
We used AlphaFold3 to predict the structure of the human GLI1-SUFU, GLI2-SUFU and GLI3-SUFU complexes (and fly Ci-Sufu), revealing three novel interfaces.
www.biorxiv.org/content/10.6...
January 8, 2026 at 3:10 PM
A preprint of our latest manuscript is out on bioRxiv.
We used AlphaFold3 to predict the structure of the human GLI1-SUFU, GLI2-SUFU and GLI3-SUFU complexes (and fly Ci-Sufu), revealing three novel interfaces.
www.biorxiv.org/content/10.6...
We used AlphaFold3 to predict the structure of the human GLI1-SUFU, GLI2-SUFU and GLI3-SUFU complexes (and fly Ci-Sufu), revealing three novel interfaces.
www.biorxiv.org/content/10.6...
Reposted by Lee Bardwell
"Announcing the Biomedical Data Translator: Initial Public Release" pubmed.ncbi.nlm.nih.gov/40635371/
Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS.
As I said in the past, best consortium ever. Awesome people.
🧪
Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS.
As I said in the past, best consortium ever. Awesome people.
🧪
Announcing the Biomedical Data Translator: Initial Public Release - PubMed
The growing availability of biomedical data offers vast potential to improve human health, but the complexity and lack of integration of these datasets often limit their utility. To address this, the ...
pubmed.ncbi.nlm.nih.gov
July 12, 2025 at 2:59 AM
"Announcing the Biomedical Data Translator: Initial Public Release" pubmed.ncbi.nlm.nih.gov/40635371/
Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS.
As I said in the past, best consortium ever. Awesome people.
🧪
Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS.
As I said in the past, best consortium ever. Awesome people.
🧪
Reposted by Lee Bardwell
It was exciting to dig into all the new discoveries in long range gene regulation while writing this!
In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...
November 22, 2024 at 10:27 PM
It was exciting to dig into all the new discoveries in long range gene regulation while writing this!
Reposted by Lee Bardwell
Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n
Xue lab at UC Irvine
Ecology and evolution in the human gut microbiome
kxuelab.com
November 19, 2024 at 6:57 PM
Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n
Cell division in the developing embryo needs to be fast, but not sloppy. An illuminating paper on this topic, from the labs of Pablo Lara-Gonzalez and Arshad Desai (which my lab was privileged to help with) is in this issue of JCB. Also a spotlight article on our work by Boland and Kamenz!
Our November cover features a maximum projection of spinning disk confocal live image showing the movements of latex fluorescent microbeads beneath ex-vivo Kif6−/− mouse ependymal tissues. By Fang et al rupress.org/jcb/article/... JCB's Nov. Issue is here: rupress.org/jcb/issue/22...
November 20, 2024 at 5:34 PM
Cell division in the developing embryo needs to be fast, but not sloppy. An illuminating paper on this topic, from the labs of Pablo Lara-Gonzalez and Arshad Desai (which my lab was privileged to help with) is in this issue of JCB. Also a spotlight article on our work by Boland and Kamenz!
This is some of what we do in my lab at UC Irvine
faculty.sites.uci.edu/bardwell
faculty.sites.uci.edu/bardwell
November 20, 2024 at 5:34 PM
This is some of what we do in my lab at UC Irvine
faculty.sites.uci.edu/bardwell
faculty.sites.uci.edu/bardwell