Mark Levin
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levinchem.bsky.social
Mark Levin
@levinchem.bsky.social
Professor of Chemistry
University of Chicago
Single-Atom Skeletal Editing
(Interspersed with doomposting and AI skepticism)
Husband, Dad, Crossword Addict
http://levingroup.uchicago.edu
Reposted by Mark Levin
✂️ July: Adventures in atom swapping!
cen.acs.org/synthesis/me...
(see also this very successful feature cen.acs.org/synthesis/Sk...)

🧪 August: Beth Halford, Laura Howes, and I revamped C&EN's first disclosures coverage to put the molecules front and center
cen.acs.org/pharmaceutic...
Skeletal editing: How close are we to true cut-and-paste chemistry?
Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll fundamentally change how molecules are made
cen.acs.org
December 31, 2025 at 8:03 PM
I don't want to gush about my own paper too much but Alex did such an amazing job - this paper has everything: a huge scope including HTE demonstration from boronic acids, some really creative mechanistic experiments and a cherry-on-top computational study that helped us sort it all out. Enjoy!
December 30, 2025 at 2:41 PM
Reposted by Mark Levin
"Schools must adopt effective filters to block inappropriate or misleading content."

What filters block misleading content from ChatGPT? Is there a "no disinfo" or "no faked citations" or "no hallucinations" filter?

There is not. This is poisoned tech. You have to block the entire product.
December 24, 2025 at 4:00 AM
Reposted by Mark Levin
As a former process chemist, yes. You get such 3am calls such as “There’s yellow foam overflowing out of the vessel, what do we do?” Or “We accidentally charged the vermiculite packing into the vessel along with the hydride reagent, it’ll be okay right?”
December 20, 2025 at 11:11 PM
Maybe they couldn't figure out how to do the positive charge on a license plate:
en.wikipedia.org/wiki/Ethanium
Ethanium - Wikipedia
en.wikipedia.org
December 15, 2025 at 5:52 PM