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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Jun 18

Great talk by Beatrix from the group on targeted long-read sequencing of the C9orf72 HRE at the ARUK Thames Valley Network Research Day in Oxford today #ALS #FTD

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Reposted by Lizzie Dellar

Molecular Neurodegeneration @molneurodegen.bsky.social · Jun 10

#ExtracellularVesicles in #TDP43 proteinopathies: pathogenesis and #biomarker potential

Elizabeth R. Dellar @lizziedellar.bsky.social Lara Nikel, Stephanie Fowler...Alexander G. Thompson #exosome #ALS #FTD

molecularneurodegeneration.biomedcentral.com/articles/10....

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

molecularneurodegeneration.biomedcentral.com

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Lizzie Dellar @lizziedellar.bsky.social · Jun 10

Very pleased to share our review in @molneurodegen.bsky.social, assessing evidence for #ExtracellularVesicle associated #TDP43. We highlight knowledge gaps relating to its biomarker usage and possible involvement in seeding of templated aggregation in #ALS, #FTD and #LATE.
doi.org/10.1186/s130...

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

doi.org

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Lizzie Dellar @lizziedellar.bsky.social · Apr 29

😱 I’m with you on the Oreos but not custard creams!

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Lizzie Dellar @lizziedellar.bsky.social · Apr 23

En route for #ISEV2025! If you want to chat EV enrichment from #brain #blood and #CSF for biomarker discovery in neurodegenerative diseases, then come and find me later this week 🫧

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Reposted by Lizzie Dellar

Dementia Researcher @dementiaresearcher.bsky.social · Apr 11

“The time to write a fellowship is when it feels right for you.” Great advice from @dryvonnecouch.bsky.social’s new guest blog on writing your first fellowship.

www.dementiaresearcher.nihr.ac.uk/blog-writing...

Dr Yvonne Couch - Blog – Writing Your First Fellowship

Dr Yvonne Couch shares wisdom (and warnings) on writing your first fellowship application — from timing and ideas to funding and salary tips.

www.dementiaresearcher.nihr.ac.uk

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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Mar 27

Also contributing were Beatrix with her poster on long-read sequencing of #C9orf72 HRE and @lizziedellar.bsky.social with her poster on #ExtracellularVesicle -based biomarker discovery in CSF.

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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Mar 27

The @mndoxford.bsky.social team enjoyed the day at the Oxford #MDUK Neuromuscular Centre meeting yesterday. In the #ALS/#MND session Alex spoke on our
studies of at-risk pre-symptomatic populations, and Kevin on the path from pre-clinical models to experimental medicine.

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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Mar 21

Excellent talk by Lizzie @lizziedellar.bsky.social from the group on discovery and validation of early biomarkers in #ALS at the Oxford Neuroscience Symposium this week.

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Lizzie Dellar @lizziedellar.bsky.social · Jan 24

Come and work with me! Research position open to work on isolation of #extracellular #vesicles for biomarker discovery in #ALS #MND. See link for more details, and reach out if you have questions. my.corehr.com/pls/uoxrecru...

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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Jan 15

Come and join us! Research assistant position open at @mndoxford.bsky.social @ndcnoxford.bsky.social, working on collecting neuroimaging data in #ALS and #FTD. Previous research experience with humans is essential. This post would suit a #Psychology or #Neuroscience graduate. See link below for info

Job Details

my.corehr.com

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Lizzie Dellar @lizziedellar.bsky.social · Dec 10

Thankyou!

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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Dec 6

We also have several group members giving platform talks as well as a plenary lecture! We would be delighted to see you there - see below for our presenters and talks #MND #ALS @mndassoc.bsky.social #alsmndsymp

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Reposted by Lizzie Dellar

Oxford MND Research @mndoxford.bsky.social · Dec 6

We are excited to be here in Montreal for @mndassoc.bsky.social #alsmndsymp! We would be delighted to see you at our posters - see below for our presenters and poster numbers #MND #ALS

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Reposted by Lizzie Dellar

Björn Vahsen @bvahsen.bsky.social · Nov 22

@mndoxford.bsky.social is now also here on Bluesky. Give it a follow to hear research updates from the whole Oxford MND Centre!

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Lizzie Dellar @lizziedellar.bsky.social · Nov 21

Congrats to Steph Fowler and team for their excellent work showing the presence of tau filaments in #extracellularvesicles derived from brain tissue in Alzheimer's disease, out in @NatureNeuro today. www.nature.com/articles/s41... Excited to see more on this!

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience

Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

www.nature.com

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Reposted by Lizzie Dellar

Dr Yvonne Couch @dryvonnecouch.bsky.social · Nov 11

Here's number 2:
(hopefully by now you have figured out where to find them and can head over and browse at your leisure!)
www.dementiaresearcher.nihr.ac.uk/guest-blog-i...

Dr Yvonne Couch - Is Leadership Important In Science?

Dr Yvonne Couch talks about leadership in research, exploring different styles and approaches and how you might apply them.

www.dementiaresearcher.nihr.ac.uk

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Reposted by Lizzie Dellar

Coleman Lab @colemanlab.bsky.social · Nov 18

This week’s Science Without Anguish post is out: the slippery slope to imposter syndrome in research and how to escape it.

Please tell your colleagues on or off social media. 🧪

www.sciencewithoutanguish.com/blog/we-are-...

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Reposted by Lizzie Dellar

Tom Driedonks @tomdriedonks.bsky.social · Nov 19

EV people unite! 😁

Natalie Turner @natalieturnerau.bsky.social · Nov 13

First attempt at a starter pack for EV people - surprisingly difficult to find everyone!

Comment if you want to be added to the list 👇

#extracellularvesicles #exosomes #microvesicles

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Reposted by Lizzie Dellar

PRIDE Database @pride-ebi.bsky.social · Nov 19

PXD051859 🚨

Elevated cerebrospinal fluid ubiquitin carboxyl-terminal hydrolase isozyme L1 levels in asymptomatic C9orf72 hexanucleotide repeat expansion carriers.

🚨 New dataset alert! 🚨

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Lizzie Dellar @lizziedellar.bsky.social · Nov 18

(3/3) We have much more work to do on this! Critically, we need to assess whether there is a longitudinal change in UCHL1 levels, and how this relates to timing of symptomatic disease.

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Lizzie Dellar @lizziedellar.bsky.social · Nov 18

(2/3) This could reflect an earlier phase of disease pathogenesis than that marked by elevation of NFL, but we do not know if it is part of a pathogenic or compensatory process.

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Lizzie Dellar @lizziedellar.bsky.social · Nov 18

(1/3) Happy to share our new work assessing protein changes in CSF of 48 asymptomatic C9orf72 variant carriers at higher risk of #ALS and #FTD.

We find an elevation in levels of UCHL1 protein, even in the absence of elevation in #neurofilament (NFL).

onlinelibrary.wiley.com/doi/full/10....

Elevated Cerebrospinal Fluid Ubiquitin Carboxyl‐Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers

Objective To identify biochemical changes in individuals at higher risk of developing amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) via C9orf72 hexanucleotide repeat expansion...

onlinelibrary.wiley.com

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Lizzie Dellar @lizziedellar.bsky.social · Nov 14

Please add, thanks!

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