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Tom Driedonks @tomdriedonks.bsky.social · 11h

Happy to have contributed to this perspectives article about interactions between therapeutic EVs and circulating B cells.
Unexpected discovery, confirmed in different experimental settings. Curious to learn more about these interactions and their therapeutic potential
pubs.acs.org/doi/10.1021/...

Extracellular Vesicles and B Cell Interactions: B-Side Track or Greatest Hit?

Substantial efforts have been made in understanding interactions between extracellular vesicles and cells, particularly in small animal models, such as rats and mice. However, many questions remain un...

pubs.acs.org

Tom Driedonks @tomdriedonks.bsky.social · 3d

Abstract submitted for #NLSEV2025!
@nlsev.bsky.social

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Tom Driedonks @tomdriedonks.bsky.social · 4d

We don't know yet, it will take a while to process all of the samples. Luckily we don't have to do all of that in one day 😄

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Tom Driedonks @tomdriedonks.bsky.social · 8d

Had a 14h shift in the lab yesterday. Mice experiment followed by magnetic sorting of different cell types from tissues. Too many washing steps but there were some cells left in the end. Next step is to see whether my EVs have reached their destination 😅

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Reposted by Tom Driedonks

International Society for Extracellular Vesicles @isev.org · 10d

We have some exciting news to share..... #JExBio is now indexed in Web of Science!!🎉🎉🎉

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Tom Driedonks @tomdriedonks.bsky.social · 17d

Yes! Mention of #extracellularvesicles in a @kurzgesagt.org popular science video about pregnancy. Wait until they learn about all the processes EVs play a role in 🤓

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Reposted by Tom Driedonks

Juan Pablo Tosar @jptosar.bsky.social · 24d

With @amyhbuck we wrote this piece on extracellular RNAs that intends not to give answers but to propose questions that can expand the field in new directions.

Hope you like it! We really enjoyed a lot brainstorming it.

journals.asm.org/doi/10.1128/...

mGem: Guides or triggers? Extracellular RNAs beyond vesicular miRNAs | mBio

Blood and other extracellular biofluids have a high RNase content. Hence, from its origins, the exRNA field has focused on extracellular vesicles (EVs) as the main carriers of RNA molecules that move ...

journals.asm.org

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Reposted by Tom Driedonks

International Society for Extracellular Vesicles @isev.org · Aug 26

😎 You can already submit your abstracts for #ISEV2026, in Puerto Rico!
🌴 Submit before 13th January 2026, there will be NO late breaking submission
www.abstractscorecard.com/cfp/submit/l...

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Reposted by Tom Driedonks

International Society for Extracellular Vesicles @isev.org · Aug 19

🎼 Did you know all #ISEV2025 Education Day Talks are on our YouTube channel?
🤩 Check out our playlist: youtu.be/ovtLcTMeyQU?...

Education Day 2025 Part 1: EVs. What are they? Where are they from? Where do they go?

YouTube video by EVClub: Extracellular Vesicle Club

youtu.be

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Reposted by Tom Driedonks

skelly @iid.bsky.social · Jul 20

do you ever stare at the ceiling and think about how the worldwide scientific establishment did the impossible and created a COVID vaccine in under a year and the response of the general public has been to go on an unstoppable rampage to destroy science and scientists

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Reposted by Tom Driedonks

International Society for Extracellular Vesicles @isev.org · Jul 4

📢Call for papers!📢 #JExBio is pleased to announce its first Special Issue 'The Biomolecular Corona of Extracellular Vesicles'. Guest Edited by Professors Massimo Bottini, Benedetta Bussolati, and Annalisa Radeghieri. isevjournals.onlinelibrary.wiley.com/hub/journal/...

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Reposted by Tom Driedonks

Kathleen Bachynski @bachynski.bsky.social · Jun 10

If you haven’t already, please consider signing & sharing this! NIH public servants defending the integrity of our publicly funded health research need our voices. This administration is
“damaging the hard-earned trust between the NIH, academia, & the public that is essential for long-term progress”

ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff

Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.

actionnetwork.org

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Tom Driedonks @tomdriedonks.bsky.social · Jun 6

Very cool findings but kit-based 'exosome' isolation kits, like used in this paper, isolate many other things in culture medium. It would be good to validate this on a proper (density gradient or size-exclusion) EV isolate

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Reposted by Tom Driedonks

Student Network on EVs @snevresearch.bsky.social · Jun 5

🚨 EV Fundamental Biology Series: The 'dark matter' RNA of Extracellular Vesicles

This June 12th, join us for a relevant talk on the vesicular RNA topic!

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Reposted by Tom Driedonks

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jun 5

More insights into #glycoRNA, this time found within exosomes!

www.nature.com/articles/s41...

Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology

Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...

www.nature.com

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Tom Driedonks @tomdriedonks.bsky.social · Jun 4

I'll do that! I noticed your thesis cover on the wall of the department, with the pelican and the ice cube. It's a small world after all!

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Tom Driedonks @tomdriedonks.bsky.social · Jun 4

Happy to have contributed to this paper by @olivier-de-jong.bsky.social!
A proper balance of loading versus unloading of Cas9 RNPs is needed for effective gene editing ⚖️
pubmed.ncbi.nlm.nih.gov/40393529/
Congratulations to all co-authors!

Modulating binding affinity of aptamer-based loading constructs enhances extracellular vesicle-mediated CRISPR/Cas9 delivery - PubMed

The CRISPR/Cas9 toolbox consists of modular nucleases that can be employed to efficiently modify genomic sequences with high specificity. However, delivery of the large Cas9-sgRNA ribonucleoprotein (R...

pubmed.ncbi.nlm.nih.gov

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Reposted by Tom Driedonks

Student Network on EVs @snevresearch.bsky.social · May 21

📢 Come be a part of the SNEV team!

We’ve got 3 exciting positions open:
1️⃣ Media Team (1 position)
2️⃣ Podcast Team (2 positions)

🗓️ Deadline to apply: May 31st
⏳ Don’t miss your chance to make an impact. Apply NOW!
📩 Link in the Linktr.ee in our bio

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Tom Driedonks @tomdriedonks.bsky.social · May 21

I deep fried two of my SDS PAGE gels today but my most important samples were on gel nr 3 so things are going quite well today 🫠

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Tom Driedonks @tomdriedonks.bsky.social · May 16

Personalized gene editing! What a time to be alive

Kathleen Bachynski @bachynski.bsky.social · May 15

“KJ’s treatment — which built on decades of federally funded research — offers a new path for companies to develop personalized treatments without going through years of expensive development… [this method] eventually could also be used for more common genetic disorders like sickle cell disease”

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

www.nytimes.com

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Tom Driedonks @tomdriedonks.bsky.social · May 15

Pretty cool study showing the effect of acid sphingomyelinase on non-coding RNA cargo of MCF-7 EVs.
Big changes in 'miscRNAs' 7SL and Y3 RNA, and functional effects in wound healing
www.sciencedirect.com/science/arti...

Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles

Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin t…

www.sciencedirect.com

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Tom Driedonks @tomdriedonks.bsky.social · May 6

Great that Europe provides opportunities for US researchers. Could strengthen Europe's position as scientific stronghold.
I hope this does not go against opportunities of European researchers. Grant money is competitive enough already, and anti science policies are on the rise here, too 😕

Ursula von der Leyen @vonderleyen.ec.europa.eu · May 5

Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

→ europa.eu/!TTbWbJ

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Tom Driedonks @tomdriedonks.bsky.social · Apr 27

NLSEV is well-represented at #ISEV2025 !

@esthernoltethoen.bsky.social @lorenowiczaims.bsky.social @cscheepbouwer.bsky.social @olivier-de-jong.bsky.social

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Reposted by Tom Driedonks

Nature @nature.com · Mar 26

Climate researchers collaborated with the trip-hop band Massive Attack to reduce the climate impact of live music

https://go.nature.com/4hXzB0Y

How a scientist–pop industry partnership slashed a live gig’s carbon emissions by 98%

Climate researchers collaborated with the trip-hop band Massive Attack to reduce the climate impact of live music.

go.nature.com

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Tom Driedonks @tomdriedonks.bsky.social · Mar 14

From 4L to 15mL, getting somewhere!
#extracellularvesicles

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