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La Jolla Institute for Immunology (LJI) @lji.org · 3h

Fighting an infection? Your T regulatory cells (Tregs) keep infection-fighting CD8+ “killer” T cells from accidentally harming too many healthy cells: bit.ly/4nZnXWs

#NobelPrize #HeartDisease #Medicine #Health #InfectiousDisease #ImmuneSystem #Immunology

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La Jolla Institute for Immunology (LJI) @lji.org · 1d

What happens if T regulatory cells (Tregs) go bad?

Scientists have linked "deprogrammed" Tregs to dangerous inflammation and cardiovascular disease: bit.ly/3Ww1hRX #NobelPrize #HeartDisease #Medicine #Health

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La Jolla Institute for Immunology (LJI) @lji.org · 1d

#NobelPrize research led by Drs. Brunkow, Ramsdell, and Sakaguchi revealed the workings of T regulatory cells (Tregs) and opened the door to new therapies for autoimmune disease!

Tregs are major players in the immune system, and they may be critical in ALS: www.nature.com/articles/s41...

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La Jolla Institute for Immunology (LJI) @lji.org · 7d

ALS as an autoimmune disease?

Jason Gale at @bloomberg.com talks with LJI Prof. Alessandro Sette (@settelab.bsky.social) about groundbreaking new findings:
www.bloomberg.com/news/article... [PAYWALL]

#immunology #health #ALS #AutoimmuneDisese #Autoimmunity

ALS Breakthrough Shows Fatal Disease Is Driven by Immune Attack

Researchers have uncovered how the body’s own immune system may be driving the progression of amyotrophic lateral sclerosis, or ALS — a breakthrough that could reshape treatment of the fatal disease.

www.bloomberg.com

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La Jolla Institute for Immunology (LJI) @lji.org · 7d

We've never known exactly what might cause ALS.

A new @nature.com paper, led by LJI Professor Alessandro Sette (@settelab.bsky.social), shows how how inflammatory T cells target the brain and trigger cell death:
www.lji.org/news-events/... #health #medicine #disease #ALS #immunology

ALS appears to be an autoimmune disease

Researchers show how inflammatory T cells target the brain and trigger cell death

www.lji.org

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Reposted by La Jolla Institute for Immunology (LJI)

Jonathan Wosen @jonathanwosen.bsky.social · 7d

Scientists have found that patients with ALS have autoimmune responses, a finding that could reshape how researchers view the devastating neurologic disorder. My latest for @statnews.com on a new study in @nature.com from @settelab.bsky.social @lji.org
www.statnews.com/2025/10/01/a...

Autoimmune responses found in ALS, pointing to a new way to view the deadly disease

Researchers have found that ALS patients have autoimmune responses, a finding with the potential to reshape how scientists think of the devastating and complex neurologic disorder.

www.statnews.com

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La Jolla Institute for Immunology (LJI) @lji.org · 8d

Exciting "Live from the Lab" webinar coming up TOMORROW, Oct. 1, at 12 PM Pacific!

Join Dr. Sonia Sharma, Dr. Amparo Martínez Pérez and Laura Hinojosa for a fascinating discussion on sex-based differences, #immunology, #endometriosis, hormonal contraceptives + more bit.ly/42PtR4o #Health #Medicine

Please join us on October 1, 2025, for La Jolla Institute for Immunology’s most recent installment of Live from the Lab, moderated by Associate Professor Sonia Sharma, Ph.D., and featuring 2025 Tullie and Rickey Families SPARK Awards for Innovations in Immunology winners Amparo Martínez Pérez, Ph.D., and Laura Hinojosa. Their conversation will explore how sex-based differences shape immune responses, with a spotlight on two fully philanthropy-funded research projects: Dr. Martínez Pérez’s investigation of specialized immune cells in menstrual blood as a novel window into endometriosis, and Hinojosa’s work mapping how hormonal contraceptives may reshape immune cell function. Together, their studies represent bold steps toward a more complete and equitable understanding of the female immune system.

Reposted by La Jolla Institute for Immunology (LJI)

Mucosal Immunology @mucosalimmunol.bsky.social · 8d

Check out our latest special collection on Skin Immunity: www.mucosalimmunology.org/mucimm-skin-...

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Reposted by La Jolla Institute for Immunology (LJI)

Miguel Reina-Campos @reinacampos.bsky.social · 23d

Violante's project at @lji.org seeks to unlock prostate cancer immunotherapies - take a peek by yourself @cancerresearchinst.bsky.social

Up close and personal with LJI’s rising immunologists | 2026 SPARK Awards Finalists

YouTube video by La Jolla Institute for Immunology

www.youtube.com

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La Jolla Institute for Immunology (LJI) @lji.org · Sep 8

"Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology."

LJI experts share key discoveries from the growing field of immunometabolism! 👇 #Tcells #Cd1Mr12025

Tom Riffelmacher @tom-riffel.bsky.social · Sep 8

Just in time for #Cd1Mr12025

Our Review on Innate-like T cell Metabolism is out!

Access free here: rdcu.be/eEV67

Please share with your Immunometabolism friends!

@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com

Metabolic control of innate-like T cells - Nature Reviews Immunology

Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...

www.nature.com

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La Jolla Institute for Immunology (LJI) @lji.org · Sep 8

Behind every experiment is a story of curiosity, resilience, and hope!☀️

LJI scientists share the personal side of their research — how their own backgrounds and their loved ones motivate them to make discoveries in #immunology:

youtu.be/EKLowprj26U?... #science #health #medicine #disease #SanDiego

The human side of science at LJI | 2026 SPARK Awards Finalists

YouTube video by La Jolla Institute for Immunology

youtu.be

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La Jolla Institute for Immunology (LJI) @lji.org · Sep 4

KPBS #Science reporter Thomas Fudge talks with LJI scientists about a fascinating new study —

Learn how "ghost" viruses in our DNA can come back to haunt us:

www.kpbs.org/news/science... #virology #SanDiego #health #medicine

Ghost viruses in our DNA can come back to haunt us

Some viruses come and go after making us sick, but some have become a part of us, passed down by our ancestors. San Diego researchers have taken a long look at these retroviruses that are part of our ...

www.kpbs.org

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La Jolla Institute for Immunology (LJI) @lji.org · Sep 4

Exciting faculty news!

Immunologist Benjamin Schmiedel, Ph.D., has been appointed to a tenure-track Assistant Professor position at LJI: bit.ly/46lL3AK

#SanDiego #LaJolla #Immunology #ImmuneSystem #Science #Health

Ben Schmiedel appointed LJI Assistant Professor

The Schmiedel Lab investigates how genetic variation affects disease risk

bit.ly

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La Jolla Institute for Immunology (LJI) @lji.org · Sep 2

The new study is #OpenAccess — and there are great videos of the #SARSCoV2 structure solved thanks to LJI's cutting-edge cryo-electron microscopy facility!

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La Jolla Institute for Immunology (LJI) @lji.org · Sep 2

Another great new @cp-cellreports.bsky.social paper from LJI's Saphire Lab —

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation: bit.ly/4lTts7K #COVID19 #virology #StructuralBiology #CellularBiology #Health #Medicine

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

Olmedillas, Rajamanickam et al. stabilize a SARS-CoV-2 spike S2 subunit to remain pre-fusion in the absence of S1. Antibodies from survivors and vaccinees recognize stabilized S2 and full spike alike ...

bit.ly

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Reposted by La Jolla Institute for Immunology (LJI)

Miguel Reina-Campos @reinacampos.bsky.social · Aug 29

A stunning first look at the viruses inside us by the Saphire lab

A stunning first look at the viruses inside us

LJI scientists uncover a new avenue for stopping cancers, autoimmune diseases, and more.

www.lji.org

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La Jolla Institute for Immunology (LJI) @lji.org · Aug 28

From cancer to virology—learn how early career scientists at LJI are becoming leaders in #immunology through the Tullie and Rickey Families SPARK Awards for Innovations in Immunology:

youtu.be/a4k9ZKi_HfQ?...

#health #medicine #biology #STEM #SanDiego

A bold idea could SPARK the next biomedical breakthrough | 2026 SPARK Awards Finalists

YouTube video by La Jolla Institute for Immunology

youtu.be

Reposted by La Jolla Institute for Immunology (LJI)

The American Association of Immunologists @aai.org · Aug 28

Nominate a deserving colleague for an AAI Career Award and celebrate their outstanding contributions to immunology research, service, and mentorship. Recognize excellence at all career levels, from seasoned professionals to new investigators. Deadline is Sept 10. www.aai.org/Awards/Career.

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Reposted by La Jolla Institute for Immunology (LJI)

Samuel A. Myers' lab @samyers-lab.bsky.social · Aug 27

Morgan gave such a fascinating talk at a @cshlaboratory.bsky.social meeting last year we had to invite him for an encore. Please join us @lji.org! via @mskcancercenter.bsky.social

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La Jolla Institute for Immunology (LJI) @lji.org · Aug 27

Just published — LJI researchers reveal the first 3D structure of a protein from a human endogenous retrovirus.

Your cells make this protein by expressing ancient viral DNA. And it's unlike anything seen before... www.lji.org/news-events/...

#health #medicine #SanDiego #biology #virology #science

A stunning first look at the viruses inside us

LJI scientists uncover a new avenue for stopping cancers, autoimmune diseases, and more.

www.lji.org

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Reposted by La Jolla Institute for Immunology (LJI)

Miguel Reina-Campos @reinacampos.bsky.social · Aug 27

Data access coming up soon... stay tuned!

La Jolla Institute for Immunology (LJI) @lji.org · Aug 27

Big news in #immunology: ImmGenMaps partners with BioTuring to share immune cell insights bit.ly/4mX3MrO

"This will make it possible for other scientists to cross-reference genes and cell types in their research."

@immgen.bsky.social @reinacampos.bsky.social‬ #SanDiego #Science #Health #Medicine

ImmGenMaps partners with BioTuring to share immune cell insights with researchers around the world

bit.ly

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La Jolla Institute for Immunology (LJI) @lji.org · Aug 27

Big news in #immunology: ImmGenMaps partners with BioTuring to share immune cell insights bit.ly/4mX3MrO

"This will make it possible for other scientists to cross-reference genes and cell types in their research."

@immgen.bsky.social @reinacampos.bsky.social‬ #SanDiego #Science #Health #Medicine

ImmGenMaps partners with BioTuring to share immune cell insights with researchers around the world

bit.ly

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La Jolla Institute for Immunology (LJI) @lji.org · Aug 26

Congratulations to LJI Professor, President & CEO Erica Ollmann Saphire, Ph.D., MBA!

Dr. Saphire has been named the 2025 Mainly Mozart #SanDiego Genius Award Honoree in recognition of her groundbreaking #immunology research and leadership in the scientific community! 🔬

www.mainlymozart.org/genius

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Reposted by La Jolla Institute for Immunology (LJI)

Sigma Xi @sigmaxi.bsky.social · Aug 18

#SigmaXiAwards @lji.org
Congratulations to our 2025 Procter Prize recipient, La Jolla Institute for Immunology's Alessandro Sette.
Read More: ow.ly/qFn350WHSR7
Awards: ow.ly/pTxi50WHSR6
IFoRE: ow.ly/jubN50WHSR8

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La Jolla Institute for Immunology (LJI) @lji.org · Aug 18

New in Protein Science 🔬

LJI Prof. Bjoern Peters (@bjoernpeters.bsky.social) and colleagues analyze large-scale T-cell receptor sequence data to uncover determinants of MHC-I versus MHC-II recognition —

onlinelibrary.wiley.com/doi/10.1002/... #ImmuneSystem #Tcells #Immunology #Health #Medicine

T‐cell receptor insights: Determinants of Major Histocompatibility Complex class I versus class II recognition

In this study, we analyzed large-scale T-cell receptor (TCR) sequence data to determine whether TCRs preferentially bind to major histocompatibility complex (MHC) class I (CD8+) or class II (CD4+) ep....

onlinelibrary.wiley.com

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