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lkremer1.bsky.social
Laurent Kremer
@lkremer1.bsky.social
470 followers 310 following 7 posts
Research Director at INSERM. TB and NTM drug discovery, pathogenesis, cell wall, zebrafish. History, classical music & opera.
Posts Media Videos Starter Packs
Reposted by Laurent Kremer
jayanta-amr.bsky.social
Jayanta Haldar @jayanta-amr.bsky.social · 25d
Announcing a call for a special issue on Nontuberculous Mycobacterial (NTM) Pathogens, led by our guest editors Sidharth Chopra, Arunava Dasgupta and @lkremer1.bsky.social! Accepting manuscripts on various themes.
Deadline - March 30, 2026.
@pubs.acs.org
Link - pubs.acs.org/doi/10.1021/...
Call for Papers: Nontuberculous Mycobacterial (NTM) Pathogens─Biology, Infection, and Drug Discovery
pubs.acs.org
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Reposted by Laurent Kremer
febsopenbio.bsky.social
febsopenbio.bsky.social @febsopenbio.bsky.social · 26d
🦠 Intrabacterial lipid inclusion-associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis

🔓https://buff.ly/fI7675n

@canaanlab.bsky.social @lkremer1.bsky.social @pierresantucci.bsky.social

#LipidMetabolism #Mycobacterium
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Aug 11
Thrilled to share our most recent paper describing the antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria in macrophages and zebrafish. Outstanding work headed by Yara Tasrini, John Jairo Aguilera Correa, Miguel Gisbert and others.
rdcu.be/eAcN4
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Jul 17
Now out in Trends In Microbiology! Iron-sulfur proteins in mycobacteria: Master regulators of physiology and pathogenesis. Kudos to Valentin Berdal and Wassim Daher. Fantastic exchanges and discussions with leaders in the field: Béatrice Py, Sandrine Ollagnier de Choudens
lnkd.in/dKGd2P8S
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Reposted by Laurent Kremer
jefcavalier.bsky.social
J.-F. Cavalier @jefcavalier.bsky.social · May 29
It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊

pubs.acs.org/doi/10.1021/...
Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes
Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...
pubs.acs.org
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Reposted by Laurent Kremer
cnrsbiologie.bsky.social
CNRS Biologie @cnrsbiologie.bsky.social · Apr 15
👋 @lkremer1.bsky.social @cnrs-hautsdefrance.bsky.social @inserm.fr @univlille.bsky.social @ugsf-lille.bsky.social @umontpellier.bsky.social

👉 Lire l'article dans @naturecomms.bsky.social

buff.ly/Z5szsdt
A glycosylated lipooctapeptide promotes uptake and growth of Mycobacterium abscessus in the host - Nature Communications
Leclercq et al report the structure of a glycosylated lipooctapeptide (GL8P) produced by Mycobacterium abscessus. GL8P is shown to induce a strong humoral response in infected patients and to…
www.nature.com
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Reposted by Laurent Kremer
zebrafishrock.bsky.social
Zebrafish Rock! @zebrafishrock.bsky.social · Apr 9
@mirimiam.bsky.social‬ @fedemantica.bsky.social (Gene duplication/ Splicing/ Evolution)
https://doi.org/10.1002/bies.202400202

@lkremer1.bsky.social‬ (Drug discovery/ Non-tuberculous mycobacteria)
https://perspectivesinmedicine.cshlp.org/content/early/2025/03/27/cshperspect.a041832 (29/34)
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Apr 8
Happy to let you know that our most recent paper describing the discovery, structure and biological functions of a new glycolipid in M. abscessus is now out ! This has only be possible thanks to a wonderful collaboration with the teams of JL Herrmann and Y Guerardel.
rdcu.be/egVwe
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Mar 28
Check out our last collaborative review article on the zebrafish models for drug discovery and therapeutic validation against non-tuberculous mycobacteria. Exciting discussions and interactions with Matt Johansen, Claire Hamela and Yi Ding.
perspectivesinmedicine.cshlp.org/cgi/reprint/...
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Reposted by Laurent Kremer
map-proteomique.bsky.social
MaP-Proteomique @map-proteomique.bsky.social · Dec 4
Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
link.springer.com
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Reposted by Laurent Kremer
canaanlab.bsky.social
canaanlab.bsky.social @canaanlab.bsky.social · Feb 25
Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...
A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio
This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...
journals.asm.org
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Feb 4
Thanks Joel!!
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Feb 4
Thrilled to share the last work from the lab! Generating a mycobacterial strain lacking all T7SS and studying the contribution of ESX-3 and ESX-4 in M. abscessus pathogenesis. Great collab with E Tocheva and JL Herrmann.
rdcu.be/d8uHH
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lkremer1.bsky.social
Laurent Kremer @lkremer1.bsky.social · Dec 16
Cold Spring Harbor Asia meeting on Mycobacterial Pathogenesis and Host Response, Suzhou, China, March 17-21, 2025. Abstract deadline Jan 10, 2025. www.csh-asia.org?content/2606
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Reposted by Laurent Kremer
phagepapers.bsky.social
Phage papers @phagepapers.bsky.social · Dec 9
Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis.

DOI: 10.1128/mbio.02970-24

https://pubmed.ncbi.nlm.nih.gov/39475242/
Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis - PubMed
Mycobacteria produce a large repertoire of surface-exposed lipids with major biological functions. Among these lipids, trehalose polyphleates (TPPs) are instrumental in the infection of <i>Mycobacterium abscessus</i> by the therapeutic phage BPs. However, while the biosynthesis and transport of TPPs …
pubmed.ncbi.nlm.nih.gov
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Reposted by Laurent Kremer
jefcavalier.bsky.social
J.-F. Cavalier @jefcavalier.bsky.social · Dec 3
Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social

jbiomedsci.biomedcentral.com/articles/10....
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
jbiomedsci.biomedcentral.com
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Reposted by Laurent Kremer
wilbertbitter.bsky.social
Wilbert Bitter @wilbertbitter.bsky.social · Nov 13
Together with Abdallah and Qingtian we just published this pan-genome analysis for M. marinum. I think it is a nice catalog, but standing out for me was the variation in the cpnT gene and the fact that ESX-2 is present in the majority of the M. marinum strains, just not in the type strain M...
Comprehensive pan-genome analysis of Mycobacterium marinum: insights into genomic diversity, evolution, and pathogenicity - Scientific Reports
Scientific Reports - Comprehensive pan-genome analysis of Mycobacterium marinum: insights into genomic diversity, evolution, and pathogenicity
www.nature.com
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Reposted by Laurent Kremer
heran.bsky.social
Heran Darwin, PhD @heran.bsky.social · May 16
If you're interested in learning about the latest of fundamental mycobacteriology, sign up for #GRCMyco2025! Acceptances will start in September, check out the full program and please RT!
heran.bsky.social
Heran Darwin, PhD @heran.bsky.social · Feb 12
We're live with the program!
www.grc.org/biology-of-m...
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