Lightnews — Scholar-powered news

canaanlab.bsky.social @canaanlab.bsky.social · Jun 25

Once again a great collaboration with @ibmm-balard.bsky.social @map-proteomique.bsky.social and other !!!

J.-F. Cavalier @jefcavalier.bsky.social · Jun 25

Today is a great day!
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...

👉 onlinelibrary.wiley.com/doi/10.1002/...

The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae

Gram-negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high-priority pathogens. One strategy that has increased is the u...

onlinelibrary.wiley.com

4

Reposted

Olivier Neyrolles @oneyrolles.bsky.social · Jun 17

Honored to award the title of Dr. honoris causa of the University of Toulouse to Dr. Manjula Reddy (CCMB, Hyderabad).
A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳

1 4 12

Reposted

Healthcare-Global @healthcare-global.bsky.social · Jun 17

newsable.asianetnews.com/internationa...

BREAKTHROUGH! Scientists discover Llama antibodies that can fight COVID and its future variants

Scientists have unearthed a rare class of ultra-potent antibodies derived from llamas that can neutralize a vast array of coronaviruses—including SARS-CoV-1 and multiple forms of SARS-CoV-2, both old ...

newsable.asianetnews.com

1 1 9

Reposted

J.-F. Cavalier @jefcavalier.bsky.social · May 29

It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊

pubs.acs.org/doi/10.1021/...

Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes

Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...

pubs.acs.org

5 6

Reposted

Luc Camoin @camoinluc.bsky.social · Apr 29

We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social

J.-F. Cavalier @jefcavalier.bsky.social · Apr 25

⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org

pubs.rsc.org/en/content/a...

Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus

The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...

pubs.rsc.org

3 3

Reposted

J.-F. Cavalier @jefcavalier.bsky.social · Apr 25

⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org

pubs.rsc.org/en/content/a...

Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus

The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...

pubs.rsc.org

3 5

canaanlab.bsky.social @canaanlab.bsky.social · Apr 22

A new story on antimicrobial peptides published with great collaborators !!

J.-F. Cavalier @jefcavalier.bsky.social · Apr 22

Happy to share our new article in Current Research in Microbial Sciences @canaanlab.bsky.social
Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb.

www.sciencedirect.com/science/arti...

Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria

Despite the availability of antibiotics, tuberculosis (TB), caused by Mycobacterium tuberculosis, was once again declared the world's leading cause of…

www.sciencedirect.com

1

Reposted

Tracy Palmer @proftracypalmer.bsky.social · Apr 9

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates

jobs.ncl.ac.uk

1 69 31

Reposted

Tracy Palmer @proftracypalmer.bsky.social · Apr 9

And here jobs.ncl.ac.uk/job/Newcastl...

Research Associate - Biochemical and structural analysis of bacterial protein toxins

jobs.ncl.ac.uk

15 9

Reposted

canaanlab.bsky.social @canaanlab.bsky.social · Feb 27

Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social

Pierre Santucci @pierresantucci.bsky.social · Feb 24

Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌

@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social

1 1

canaanlab.bsky.social @canaanlab.bsky.social · Apr 10

Great job !!👏👏👏👏to all authors !

Laurent Kremer @lkremer1.bsky.social · Apr 8

Happy to let you know that our most recent paper describing the discovery, structure and biological functions of a new glycolipid in M. abscessus is now out ! This has only be possible thanks to a wonderful collaboration with the teams of JL Herrmann and Y Guerardel.
rdcu.be/egVwe

canaanlab.bsky.social @canaanlab.bsky.social · Feb 27

Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social

Pierre Santucci @pierresantucci.bsky.social · Feb 24

Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌

@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social

1 1

canaanlab.bsky.social @canaanlab.bsky.social · Feb 25

Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio

This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...

journals.asm.org

6 14

canaanlab.bsky.social @canaanlab.bsky.social · Dec 9

Nice work congratulations Alexandre and co authors 👏👏👏

Tiago Beites @tiagobeites.bsky.social · Dec 8

A very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 3

Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...

canaanlab.bsky.social @canaanlab.bsky.social · Dec 9

You are perfectly right !!! Authors please do not use this nomenclature anymore !!!!

Olivier Neyrolles @oneyrolles.bsky.social · Dec 8

When the title of a paper makes it painfully clear that no expert in the field was involved in its review...
Bravo #MolecularMicroEditors 👏
#PeerReview #MicroSky
onlinelibrary.wiley.com/doi/abs/10.1...

ClpS Directs Degradation of N‐Degron Substrates With Primary Destabilizing Residues in Mycolicibacterium smegmatis

Many bacteria possess an N-degron pathway that links the proteolytic stability of proteins to the identity of their N-terminal residue. Here, we report that Mycolicibacterium smegmatis possesses a ph...

onlinelibrary.wiley.com

1

Reposted

MaP-Proteomique @map-proteomique.bsky.social · Dec 4

Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science

Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

link.springer.com

4 4

Reposted

J.-F. Cavalier @jefcavalier.bsky.social · Dec 4

After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more

febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...

febs.onlinelibrary.wiley.com

1 4 10

Reposted

J.-F. Cavalier @jefcavalier.bsky.social · Dec 3

Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social

jbiomedsci.biomedcentral.com/articles/10....

Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science

Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...

jbiomedsci.biomedcentral.com

4 8

canaanlab.bsky.social @canaanlab.bsky.social · Dec 2

Happy to share scientific @pierresantucci.bsky.social paper useful to facilitate screening of CrispRi mutants @Febs letters
Doi: 10.1002/1873-3468.15071

1

Reposted

Gabriele Pollara @gpollara.bsky.social · Nov 25

Interesting paper showing different M tuberculosis strains induce varying levels of IL-1beta via inflammasome activation.

Curious to understand how that relates to infection clearance & disease severity.

#TBSky #IDSky #ImmunoSky #Immunometabolism

Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring

The glycolytic pathway is required for maximum IL-1β production by macrophages infected with live distinct M. tuberculosis isolates, but mitochondria metab

academic.oup.com

1 6 36