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Pierre Santucci

@pierresantucci.bsky.social

780 followers 1.2K following 22 posts

PI CNRS - Aix Marseille Université 🇫🇷🇪🇺 All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊 https://pierre-santucci.owlstown.net/

pierre-santucci.owlstown.net

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Pierre Santucci @pierresantucci.bsky.social · Feb 24

Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌

@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social

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Reposted by Pierre Santucci

Shabaana Khader @khadershabaana.bsky.social · 4d

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Pierre Santucci

Shabaana Khader @khadershabaana.bsky.social · 4d

Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!

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Reposted by Pierre Santucci

Christophe 🔬 L @christlet.bsky.social · 6d

Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...

The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)

This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...

themicroscopists.bitesizebio.com

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Pierre Santucci @pierresantucci.bsky.social · 7d

Yeaaaah Congratulations @ben-ezraty.bsky.social & team - You guys Rock! 🤘💥

Reposted by Pierre Santucci

PLOS Biology @plosbiology.org · 8d

During chlorite-induced #OxidativeStress MsrPQ repairs periplasmic proteins oxidized at Met residues. @ben-ezraty.bsky.social &co show that in these conditions the #Ecoli chaperone Spy is overproduced & oxidized; its reduction by MsrPQ helps maintain functionality @plosbiology.org 🧪 plos.io/3VHTAI9

Maintaining Spy in its reduced state (left) by MsrP during chlorite stress is critical for its chaperone activity. Image credit: Benjamin Ezraty.

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Reposted by Pierre Santucci

Andy Edwards @bugsinblood.bsky.social · 10d

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

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Pierre Santucci @pierresantucci.bsky.social · 10d

Thanks Tiago! ✌️✌️✌️

Pierre Santucci @pierresantucci.bsky.social · 10d

Work led by the talented PhD Candidate Janïs Laudouze, close collaboration with
@alainbaulard.bsky.social
Yuri Antonenko
@alexandregouzy.bsky.social

Big thanks to our funders:
@cnrsbiologie.bsky.social
@univ-amu.fr
@anrs-mie.bsky.social
@agencerecherche.bsky.social

Pierre Santucci @pierresantucci.bsky.social · 10d

🙏🙏🙏 Thanks so much @sfmpathogenesis.bsky.social for the shout out - You guys rock! ✌️✌️✌️

Pierre Santucci @pierresantucci.bsky.social · 10d

Extremely happy to share the fruit of a beautiful collaborative research study.

France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺

Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇

doi.org/10.1101/2025...

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

doi.org

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Reposted by Pierre Santucci

SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 10d

New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky

✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q

Revisited model of PZA/HPOA efficacy, supporting a pH-dependent mechanism of weak acid permeation and cytosolic acidification as main mechanism of bactericidal activity. In this model, the authors propose that the presence of glycerol potentiates PZA/HPOA efficacy by generating acidic intermediates that lower IBpH. Accordingly, β-alanine and pantothenate might mitigate this effect by acting as buffering molecules that alleviate acidosis. Finally, PanD enzymatic activity consumes protons which in turn increases IBpH. Therefore, in this model PanD minimally contributes to PZA tolerance and cannot be considered as the primary target of the drug.

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Reposted by Pierre Santucci

J.-F. Cavalier @jefcavalier.bsky.social · 11d

Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11d

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1

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Reposted by Pierre Santucci

Cascales Lab @cascaleslab.bsky.social · 11d

We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !

Stay tuned !!

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Reposted by Pierre Santucci

Géraldine Laloux @lalouxlab.bsky.social · 14d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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Reposted by Pierre Santucci

febsopenbio.bsky.social @febsopenbio.bsky.social · 15d

📢FEBS Open Bio is an affiliate journal in @ReviewCommons

📩We can receive your refereed preprint with no need to re-submit!

🔎Focus on technical and ethical quality
📖Publish #OpenAccess
👐Not-for-profit: net income supports science

#BioPhysics #Biochemistry #CellBiology

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Pierre Santucci @pierresantucci.bsky.social · 16d

👏👏👏 Congratulations Wendy, Oli & Team - Fantastic to see this beautiful story published! 💥🎉🎊

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Reposted by Pierre Santucci

Olivier Neyrolles @oneyrolles.bsky.social · 16d

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC

Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS

Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

www.pnas.org

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Reposted by Pierre Santucci

Richard Sever @richardsever.bsky.social · Sep 4

Funder information can now be added to bioRxiv preprints. Incorporation of funding organizations into the Research Organization Registry (ROR) means this is available as standardized metadata for articles.

connect.biorxiv.org/news/2025/09...

Adding funder information to bioRxiv preprints

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

connect.biorxiv.org

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Reposted by Pierre Santucci

Jessica Blair @jessicamablair.bsky.social · Sep 4

Assistant Prof post in bacterial genomics @unibirmingham.bsky.social Come and join us!!

@imibirmingham.bsky.social
www.jobs.ac.uk/job/DOO184/a...

Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham

Looking for a new job opportunity in academia? Check out this job opening for a Assistant Professor (Research and Education) in Bacterial Genomics on jobs.ac.uk!

www.jobs.ac.uk

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Reposted by Pierre Santucci

Journal of Cell Biology @jcb.org · Sep 3

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility

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Reposted by Pierre Santucci

Jan-Willem Veening @veeninglab.com · Sep 3

Cool preprint by Mathieu Berge @polardlab.bsky.social showing that the Spr1630 toxin (RipA) toxin targets the replication sliding-clamp (DnaN) and that this induces competence in Streptococcus pneumoniae. www.biorxiv.org/content/10.1...

A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae.

Streptococcus pneumoniae is a pathogenic bacterium capable of entering a cellular differentiation state, called competence, which enables it to acquire new genetic functions by natural transformation,...

www.biorxiv.org

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Pierre Santucci @pierresantucci.bsky.social · Aug 24

👏👏👏👏

Reposted by Pierre Santucci

Guzzo lab - Lyon @mguzzo.bsky.social · Aug 24

Check out the first preprint from our lab describing a direct molecular cross-talk between (p)ppGpp and c-di-GMP nucleotide messengers! Great work from first-author Corentin Jaboulay who was a postdoc in our lab, and great collaborations! @mmsb-lyon.bsky.social @cnrsbiologie.bsky.social

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Aug 24

Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition https://www.biorxiv.org/content/10.1101/2025.08.22.671821v1

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Pierre Santucci @pierresantucci.bsky.social · Aug 20

👏👏👏Congrats Sofia & Thanks to IUBMB, FEBS and PABMB for the support! 👌😎

Reposted by Pierre Santucci

iubmb.bsky.social @iubmb.bsky.social · Aug 20

🎉 Congratulations to Maria Sofia Deschutter from the National University of Rosario 🇦🇷, who was awarded the IUBMB-FEBS-PABMB PROBio-LatAm fellowship to @pierresantucci.bsky.social at the Laboratoire d’Ingénierie des Systèmes Macromoléculaires CNRS Aix-Marseille University 🇫🇷.

@sfbbm.bsky.social

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