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Alexandre Gouzy

@alexandregouzy.bsky.social

380 followers 440 following 14 posts

Assistant professor at @ehrtschnaplab @weillcornell. TB microbiologist. Into nutritional immunity 🍭drug resistance💊 & stringent response🚨🇫🇷🇪🇺🇺🇸

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Alexandre Gouzy @alexandregouzy.bsky.social · Dec 3

Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...

An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH | mBio

Despite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease killer worldwide. A better understanding of the en...

journals.asm.org

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Alexandre Gouzy @alexandregouzy.bsky.social · 11d

Thank you Tiago 😘

Alexandre Gouzy @alexandregouzy.bsky.social · 11d

Great work by @pierresantucci.bsky.social and co. Always fun and easy to collaborate with you. Thank you for including me in this study 😊

SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 12d

New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky

✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q

Revisited model of PZA/HPOA efficacy, supporting a pH-dependent mechanism of weak acid permeation and cytosolic acidification as main mechanism of bactericidal activity. In this model, the authors propose that the presence of glycerol potentiates PZA/HPOA efficacy by generating acidic intermediates that lower IBpH. Accordingly, β-alanine and pantothenate might mitigate this effect by acting as buffering molecules that alleviate acidosis. Finally, PanD enzymatic activity consumes protons which in turn increases IBpH. Therefore, in this model PanD minimally contributes to PZA tolerance and cannot be considered as the primary target of the drug.

Reposted by Alexandre Gouzy

Olivier Neyrolles @oneyrolles.bsky.social · Feb 21

Huge thanks to @marcopsilva.bsky.social, Thales Costa and all the students for the kind invite to speak at the @i3suporto.bsky.social Student symposium! 🌟
Top-notch organization, amazing vibes, and a truly warm welcome, an unforgettable experience! 🙏
#i3Ssymposium

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Reposted by Alexandre Gouzy

Olivier Neyrolles @oneyrolles.bsky.social · Feb 10

Terrific @embl.org #EMBO meeting on #Tuberculosis in Hyderabad, India! Fantastic to reconnect with friends & colleagues, dive into top-notch science (gut feeling included 😉), and be inspired by brilliant students & postdocs. Great talks, great food, what a blast! 🔥👏 #TBScience #MicroSky

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Alexandre Gouzy @alexandregouzy.bsky.social · Feb 14

Too bad I missed this event and your talk. I am sure both were fantastic 👌👏

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Reposted by Alexandre Gouzy

Tiago Beites @tiagobeites.bsky.social · Feb 12

What a great conference #EMBOtuberculosis has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work we’re developing at i3S U. Porto.

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Reposted by Alexandre Gouzy

The Francis Crick Institute @crick.ac.uk · Dec 31

Huge congratulations to Robert Wilkinson on being recognised with an OBE in the New Year’s Honours list for his services to infectious disease research.

Read more about Robert’s work on tuberculosis at the Crick, @imperialcollegeldn.bsky.social and UCT

www.crick.ac.uk/news/2024-12...

Robert J Wilkinson awarded an OBE in the New Year Honours List

www.crick.ac.uk

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Alexandre Gouzy @alexandregouzy.bsky.social · Dec 8

Thanks Melanie!!

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 8

Thanks my dear friend 😙

Reposted by Alexandre Gouzy

Michael Glickman @michaelglickman.bsky.social · Dec 5

I have done this frequently and agree it is very valuable. Removing the presumed quality imprint of the journal name opens up the discussion dramatically in my experience.

eLife @elife.bsky.social · Nov 26

10/ Why should you bring #preprints into your journal club?

Here’s what #ECRs stand to gain by looking beyond published papers.
https://buff.ly/3VbvNjT

Point of View: Journal clubs in the time of preprints

Early-career researchers can learn about peer review by discussing preprints at journal clubs and sending feedback to the authors.

buff.ly

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Alexandre Gouzy @alexandregouzy.bsky.social · Dec 5

Thank you! I was lucky to work with you. To many more!!

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 5

Merci Caro ☺️

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 4

Thank you Olivier 😙

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 4

Thank you very much 😉

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 4

Thank you Juju! 😘

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 4

Merci Pierre :)

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 4

Thanks Max 😉

Alexandre Gouzy @alexandregouzy.bsky.social · Dec 3

An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH | mBio

journals.asm.org

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Reposted by Alexandre Gouzy

Chris @drchriskellogg.bsky.social · Nov 23

Oh look! @asm.org is here now 🧪🧫

Screen grab of @asm.org account page “Official account of the American Society for Microbiology”

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Alexandre Gouzy @alexandregouzy.bsky.social · Nov 20

Imaginary, really 🧐

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Reposted by Alexandre Gouzy

Olivier Neyrolles @oneyrolles.bsky.social · Nov 20

My partner has finally joined Blue! Follow him if you love painting, pastels, photography, and beautiful things! 😉

Yannick Verkindere @yanverk.bsky.social · Nov 20

Portrait of an imaginary man.

#PastelPainting #FrenchArtist #PastelArt #Art #Portrait #Painting #SoftPastel #PortraitPainting #blueskyart

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Reposted by Alexandre Gouzy

Jay Hinton @jayhinton.bsky.social · Nov 20

New Salmonella Persister cells Review is just out❗️

Rachel Giorgio & Sophie Helaine overview the physiology & clinical implications of antibiotic-recalcitrant Salmonella during infection

- highlighting important knowledge gaps that need to be addressed…

www.nature.com/articles/s41...

Antibiotic-recalcitrant Salmonella during infection - Nature Reviews Microbiology

In this Review, Giorgio and Helaine provide an overview of the physiology of antibiotic-recalcitrant Salmonella enterica during infection, discuss recent insights into the clinical implications of ant...

www.nature.com

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Reposted by Alexandre Gouzy

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · Nov 20

Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...

Research Assistant in Tissue Immunology:Oxford Road

www.jobs.manchester.ac.uk

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Reposted by Alexandre Gouzy

Angie Rasmussen @angierasmussen.bsky.social · Nov 19

I spoke to @mscribe.bsky.social @theguardian.com about the H5N1 case in BC.

More and more human cases are occurring, along with mutations that indicate further human adaptation.

We need to treat these cases like a warning, because that is what they are.

www.theguardian.com/world/2024/n...

Bird flu in Canada may have mutated to become more transmissible to humans

Scientists are racing to understand what a hospitalized teen’s case of bird flu may mean for future outbreaks

www.theguardian.com

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Reposted by Alexandre Gouzy

Olivier Neyrolles @oneyrolles.bsky.social · Nov 19

🎉🌍🚀 Our AMAZING PhD superstar, Wendy Le Mouëllic, has landed in Abidjan, Ivory Coast, to take the #MT180 international final by storm! 🏆💥 We’re 1000% sure she’s bringing her A-game (and maybe a trophy 🏅). LET’S GO, WENDY!! 🎤💃 Show the world what IPBS talent is made of! 💪🔥 #TeamWendy #ScienceChampion

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