Jay Hinton
@jayhinton.bsky.social
Salmonella admirer & Prof of Microbiology - Working on Salmonella bloodstream infections (iNTS) in sub- Saharan Africa context. Functional genomics. T1D.
Reposted by Jay Hinton
#microsky #phagesky #phage
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage
Abstract. Transformation occurs when bacteria import exogenous DNA via the competence machinery and integrate it into their genome through homologous recom
academic.oup.com
November 23, 2025 at 4:39 PM
#microsky #phagesky #phage
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.
academic.oup.com/mbe/article/...
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year…
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
November 24, 2025 at 8:07 PM
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year…
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️
🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Reposted by Jay Hinton
if you are interested in a PhD in tuberculosis drug discovery, check out our opportunities 🧪🦠 #Tuberculosis lstm.ac/PhD
PhD opportunities
lstm.ac
November 24, 2025 at 3:18 PM
if you are interested in a PhD in tuberculosis drug discovery, check out our opportunities 🧪🦠 #Tuberculosis lstm.ac/PhD
The sunsets at this time of year are incredible.
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
November 23, 2025 at 4:22 PM
The sunsets at this time of year are incredible.
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us.
Truly life-affirming 🌇💛 🌇💛
#Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
Reposted by Jay Hinton
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
November 20, 2025 at 6:52 PM
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
Reposted by Jay Hinton
🧫🦠🌍🧬
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 11:20 PM
🧫🦠🌍🧬
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
Alexander Harms group just made TnSeq possible for phages, enabling the possibility to infer functions over different hosts and conditions.
This will revolutionise our toolbox to understand not only phage physiology, but also ecological plasticity!
Congrats @aharms485.bsky.social!
Nottingham university to close its Microbiology course ☹️
Nottingham to suspend music and modern foreign language degrees, warning international fee levy will wipe out income from domestic fee rise. Some nursing, theology, education, microbiology and agriculture degrees hit too www.timeshighereducation.com/news/notting... via @julietterowsell.bsky.social
Nottingham suspends music, language and nursing courses
University says financial uncertainties continue as government’s proposed student levy will ‘wipe out any benefits’ from rising tuition fees
www.timeshighereducation.com
November 6, 2025 at 5:23 PM
Nottingham university to close its Microbiology course ☹️
Proud to be part of this incredible multidisciplinary team uncovering why some people are NOT infected by Salmonella. This new Wellcome Trust @wellcometrust.bsky.social funding will allow us to uncover why some people naturally resist infection and colonisation by Salmonella Typhimurium.
NEWS | Professor @jayhinton.bsky.social and an international team have been awarded £4.56M Wellcome Discovery Award to investigate natural human resistance to Salmonella
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
October 30, 2025 at 3:50 PM
Proud to be part of this incredible multidisciplinary team uncovering why some people are NOT infected by Salmonella. This new Wellcome Trust @wellcometrust.bsky.social funding will allow us to uncover why some people naturally resist infection and colonisation by Salmonella Typhimurium.
Reposted by Jay Hinton
NEWS | Professor @jayhinton.bsky.social and an international team have been awarded £4.56M Wellcome Discovery Award to investigate natural human resistance to Salmonella
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
October 27, 2025 at 3:17 PM
NEWS | Professor @jayhinton.bsky.social and an international team have been awarded £4.56M Wellcome Discovery Award to investigate natural human resistance to Salmonella
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
Reposted by Jay Hinton
🏆 Fighting the Gender Award Gap: Microbiologist Prof Dr Lisa Maier from @unituebingen.bsky.social received the main award of the German Association for #Microbiology and Hygiene at the #DGHM meeting in Jena. Congratulations to @lisamaierlab.bsky.social we are proud of you! 💜
📸 Gabriele Pradel
📸 Gabriele Pradel
September 23, 2025 at 8:39 AM
🏆 Fighting the Gender Award Gap: Microbiologist Prof Dr Lisa Maier from @unituebingen.bsky.social received the main award of the German Association for #Microbiology and Hygiene at the #DGHM meeting in Jena. Congratulations to @lisamaierlab.bsky.social we are proud of you! 💜
📸 Gabriele Pradel
📸 Gabriele Pradel
Reposted by Jay Hinton
🎓 We’re honoured to be named #THEAwards Charity Partner for 2025!
For over 90 years, Cara has defended science and learning with universities in the UK and Ireland. We're grateful for the academic community that makes our work possible.
Read more here👉: the-awards.co.uk/2025/en/page...
For over 90 years, Cara has defended science and learning with universities in the UK and Ireland. We're grateful for the academic community that makes our work possible.
Read more here👉: the-awards.co.uk/2025/en/page...
We’re pleased to announce that this year’s #THEAwards charity partner is @cara1933.bsky.social.
Cara (the Council for At-Risk Academics) supports and rescues scholars around the world facing persecution, violence or conflict.
Read more about Cara at the-awards.co.uk/2025/en/page...
Cara (the Council for At-Risk Academics) supports and rescues scholars around the world facing persecution, violence or conflict.
Read more about Cara at the-awards.co.uk/2025/en/page...
October 28, 2025 at 5:50 PM
🎓 We’re honoured to be named #THEAwards Charity Partner for 2025!
For over 90 years, Cara has defended science and learning with universities in the UK and Ireland. We're grateful for the academic community that makes our work possible.
Read more here👉: the-awards.co.uk/2025/en/page...
For over 90 years, Cara has defended science and learning with universities in the UK and Ireland. We're grateful for the academic community that makes our work possible.
Read more here👉: the-awards.co.uk/2025/en/page...
Reposted by Jay Hinton
I am delighted to be a co-investigator on this newly funded Wellcome Discovery Award. Excited to begin work with the team (including those not on Bluesky!)
@jayhinton.bsky.social @roygoodacre.bsky.social @lisamaierlab.bsky.social @blancaps.bsky.social
@jayhinton.bsky.social @roygoodacre.bsky.social @lisamaierlab.bsky.social @blancaps.bsky.social
NEWS | Professor @jayhinton.bsky.social and an international team have been awarded £4.56M Wellcome Discovery Award to investigate natural human resistance to Salmonella
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
🔗 bit.ly/4hujsRG
@livuninews.bsky.social | #TeamLivUni
October 27, 2025 at 3:30 PM
I am delighted to be a co-investigator on this newly funded Wellcome Discovery Award. Excited to begin work with the team (including those not on Bluesky!)
@jayhinton.bsky.social @roygoodacre.bsky.social @lisamaierlab.bsky.social @blancaps.bsky.social
@jayhinton.bsky.social @roygoodacre.bsky.social @lisamaierlab.bsky.social @blancaps.bsky.social
Reposted by Jay Hinton
The unique lipopolysaccharide composition of Salmonella Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell death https://www.biorxiv.org/content/10.1101/2025.09.29.679141v1
September 30, 2025 at 3:18 AM
The unique lipopolysaccharide composition of Salmonella Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell death https://www.biorxiv.org/content/10.1101/2025.09.29.679141v1
Reposted by Jay Hinton
hosting.northumbria.ac.uk/nu-omics/vom...
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
VOM-UK Conferences - NU-OMICS
Viruses of Microbes UK (VoM-UK) Conference The Virus of Microbes UK (VoM-UK) Conference is hosted by Microbiome Excellence Peak of Excellence at Northumbria University. This two-day conference takes place annually at the end of January/beginning of February and is a chance for researchers to gather and share their knowledge. The VoM-UK conference is designed to […]
hosting.northumbria.ac.uk
October 9, 2025 at 9:21 AM
hosting.northumbria.ac.uk/nu-omics/vom...
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
#phagesky #phage #microsky
Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
📈 Reported cases of non-typhoidal Salmonella in England rose by 17% — from 8,872 in 2023 to 10,388 in 2024.
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
October 7, 2025 at 5:27 AM
📈 Reported cases of non-typhoidal Salmonella in England rose by 17% — from 8,872 in 2023 to 10,388 in 2024.
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars
www.gov.uk/government/p...
Reposted by Jay Hinton
My news is that I will be joining the Liverpool School of Tropical Medicine! I'm very excited to join an organization that shares my passion for improving global health, at the same time I'm sad to leave all of the wonderful colleagues here at SCRI who I've enjoyed working with over the past ~6y 🦠🧪
LSTM welcomes three leading global health therapeutics experts with support from UKRI
Dr Jeremy Burrows, Professor Tanya Parish, and Dr Ami Patel will bring unique expertise in medicinal chemistry, drug discovery, vaccinology and antibody-based therapeutics into LSTM, enhancing its
www.lstmed.ac.uk
September 17, 2025 at 11:07 PM
My news is that I will be joining the Liverpool School of Tropical Medicine! I'm very excited to join an organization that shares my passion for improving global health, at the same time I'm sad to leave all of the wonderful colleagues here at SCRI who I've enjoyed working with over the past ~6y 🦠🧪
Reposted by Jay Hinton
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home
www.shigella2026.conferences-pasteur.org/home
September 19, 2025 at 1:12 AM
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home
www.shigella2026.conferences-pasteur.org/home
Reposted by Jay Hinton
The @microbiologysociety.org champions got together and talked about their fave #microbes on international microorganism day.
So I did a few more portraits of the little legends!
I will hopefully repost them all with alt text over the next few weeks
#sciart #microsky 🧪
So I did a few more portraits of the little legends!
I will hopefully repost them all with alt text over the next few weeks
#sciart #microsky 🧪
It’s International Microorganism Day! We asked the Society’s Champions to tell us about their favourite microbes and, our Champion, Eliza Wolfson, has created some fun illustrations to show you a bit more of their character! @eliza-coli.bsky.social @femsmicro.org #InternationalMicroorganismDay
September 18, 2025 at 8:44 AM
The @microbiologysociety.org champions got together and talked about their fave #microbes on international microorganism day.
So I did a few more portraits of the little legends!
I will hopefully repost them all with alt text over the next few weeks
#sciart #microsky 🧪
So I did a few more portraits of the little legends!
I will hopefully repost them all with alt text over the next few weeks
#sciart #microsky 🧪
Reposted by Jay Hinton
www.microbiologyresearch.org/content/jour...
It is out! Our paper from the PhD work of Huijun Long, constructing and analysing metabolic models of Avian Pathogenic E. coli ( #APEC ) in Mgen @microbiologysociety.org
With @jaimehat.bsky.social and @roblaragione.bsky.social #microsky #idsky
It is out! Our paper from the PhD work of Huijun Long, constructing and analysing metabolic models of Avian Pathogenic E. coli ( #APEC ) in Mgen @microbiologysociety.org
With @jaimehat.bsky.social and @roblaragione.bsky.social #microsky #idsky
Use of genome-scale metabolic reconstructions of avian pathogenic Escherichia coli (APEC) phylogroups for the identification of lineage-specific metabolic pathways
Avian pathogenic Escherichia coli (APEC) are a genetically diverse pathotype primarily associated with extra-intestinal infections in birds. APEC lineages are predicted to have unique metabolic capabi...
www.microbiologyresearch.org
September 17, 2025 at 8:51 PM
www.microbiologyresearch.org/content/jour...
It is out! Our paper from the PhD work of Huijun Long, constructing and analysing metabolic models of Avian Pathogenic E. coli ( #APEC ) in Mgen @microbiologysociety.org
With @jaimehat.bsky.social and @roblaragione.bsky.social #microsky #idsky
It is out! Our paper from the PhD work of Huijun Long, constructing and analysing metabolic models of Avian Pathogenic E. coli ( #APEC ) in Mgen @microbiologysociety.org
With @jaimehat.bsky.social and @roblaragione.bsky.social #microsky #idsky
Reposted by Jay Hinton
On this week, 40 years ago, my friend Ralph Isberg, then a postdoc with Stan Falkow, reported the discovery of the 1st invasin gene in @nature.com "We report here the identification of a single genetic locus from this organism (Y. pseudotuberculosis) that is sufficient to convert the innocuous
September 13, 2025 at 1:08 PM
On this week, 40 years ago, my friend Ralph Isberg, then a postdoc with Stan Falkow, reported the discovery of the 1st invasin gene in @nature.com "We report here the identification of a single genetic locus from this organism (Y. pseudotuberculosis) that is sufficient to convert the innocuous
Reposted by Jay Hinton
We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
INSTITUT PASTEUR - Technicien de recherche Microbiologie H/F
emploi.pasteur.fr
September 12, 2025 at 2:42 PM
We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!
Reposted by Jay Hinton
✅ Live in England? 📍
✅ Are several members of your family willing to give a stool sample? 👪
You can take part in our PEARL-AGE study understanding how microbes are shared within families.
➡️ buff.ly/3B9QJkh
@earlhaminst.bsky.social
✅ Are several members of your family willing to give a stool sample? 👪
You can take part in our PEARL-AGE study understanding how microbes are shared within families.
➡️ buff.ly/3B9QJkh
@earlhaminst.bsky.social
September 9, 2025 at 3:04 PM
✅ Live in England? 📍
✅ Are several members of your family willing to give a stool sample? 👪
You can take part in our PEARL-AGE study understanding how microbes are shared within families.
➡️ buff.ly/3B9QJkh
@earlhaminst.bsky.social
✅ Are several members of your family willing to give a stool sample? 👪
You can take part in our PEARL-AGE study understanding how microbes are shared within families.
➡️ buff.ly/3B9QJkh
@earlhaminst.bsky.social
Reposted by Jay Hinton
Crisis at England universities created by successive govts.
Freeze on student fees
Real cuts in govt grants
Harder to enrol foreign students
Home student numbers falling
£267bn student debt
Real wage cuts
40% of universities in trouble.
Local economies decline with university decline
Freeze on student fees
Real cuts in govt grants
Harder to enrol foreign students
Home student numbers falling
£267bn student debt
Real wage cuts
40% of universities in trouble.
Local economies decline with university decline
The Guardian view on university finances: stop chipping away at a crumbling system | Editorial
Editorial: Economic and academic activity are bound up together. Charging international students more for less will not fix deep-seated problems
www.theguardian.com
September 9, 2025 at 6:52 AM
Crisis at England universities created by successive govts.
Freeze on student fees
Real cuts in govt grants
Harder to enrol foreign students
Home student numbers falling
£267bn student debt
Real wage cuts
40% of universities in trouble.
Local economies decline with university decline
Freeze on student fees
Real cuts in govt grants
Harder to enrol foreign students
Home student numbers falling
£267bn student debt
Real wage cuts
40% of universities in trouble.
Local economies decline with university decline
Reposted by Jay Hinton
A plasmid golden ratio? 🧬
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
September 9, 2025 at 3:54 AM
A plasmid golden ratio? 🧬
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky
Reposted by Jay Hinton
Honored to have received the 2026 ASM Award for Early Career Basic Research. This award is also a recognition of my phenomenal trainees and their hard work. Thank you to the mentors that have supported my career and those who have nominated me for this award.
asm.org/press-releas...
asm.org/press-releas...
September 5, 2025 at 8:09 PM
Honored to have received the 2026 ASM Award for Early Career Basic Research. This award is also a recognition of my phenomenal trainees and their hard work. Thank you to the mentors that have supported my career and those who have nominated me for this award.
asm.org/press-releas...
asm.org/press-releas...