Emmanuele Severi
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emmseveri.bsky.social
Emmanuele Severi
@emmseveri.bsky.social
1.2K followers 1.1K following 310 posts
Research Fellow at Northumbria University: phage, synthetic biology, sialic acid, transport proteins. He/him.
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emmseveri.bsky.social
Emmanuele Severi @emmseveri.bsky.social · Oct 9
hosting.northumbria.ac.uk/nu-omics/vom...

#phagesky #phage #microsky

Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
VOM-UK Conferences - NU-OMICS
Viruses of Microbes UK (VoM-UK) Conference The Virus of Microbes UK (VoM-UK) Conference is hosted by Microbiome Excellence Peak of Excellence at Northumbria University. This two-day conference takes place annually at the end of January/beginning of February and is a chance for researchers to gather and share their knowledge. The VoM-UK conference is designed to […]
hosting.northumbria.ac.uk
Reposted by Emmanuele Severi
cyanoney.bsky.social
2 days left to apply for a fully funded MIBTP Phd project with me at the School of Life Sciences @warwicklifesci.bsky.social at Warwick. We will do viral functional metagenomics and other cool techniques.

Check out the details and apply in the link below

warwick.ac.uk/fac/cross_fa...
November 25, 2025 at 2:54 PM
emmseveri.bsky.social
#microsky #phagesky

Transposon mutagenesis of jumbo #phage using an anti-CRISPR factor as selectable marker

www.biorxiv.org/content/10.1...
Bacteriophage genome-wide transposon mutagenesis
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward genetics has defined essential gen...
www.biorxiv.org
November 25, 2025 at 8:07 AM
emmseveri.bsky.social
#microsky #phagesky

More on how Arbitrium regulates temperate #phage lifestyle in Bacillus

www.biorxiv.org/content/10.1...
Arbitrium systems control lysis/lysogeny through the regulation of small antirepressor proteins
Many temperate Bacillus phages utilize the arbitrium signaling system to control lysis/lysogeny decisions. While the function of the arbitrium signal AimP and its receptor AimR are well known, it is u...
www.biorxiv.org
November 25, 2025 at 8:05 AM
Reposted by Emmanuele Severi
henrikstrahl.bsky.social
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
November 24, 2025 at 8:20 PM
emmseveri.bsky.social
#microsky

On the challenges of identifying plasmids from WGS

journals.asm.org/doi/10.1128/...
Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations | Antimicrobial Agents and Chemotherapy
Antimicrobial resistance (AMR) is a major concern in public health, with over 5 million deaths associated with bacterial AMR (1). AMR can be conferred by de novo mutations on the chromosome or through...
journals.asm.org
November 24, 2025 at 7:52 PM
emmseveri.bsky.social
#microsky

New on the regulation of porins function in E. coli.

www.nature.com/articles/s41...
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology
The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.
www.nature.com
November 24, 2025 at 7:44 PM
Reposted by Emmanuele Severi
fronzeslab.bsky.social
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex - Nature Communications
The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon...
doi.org
November 24, 2025 at 3:22 PM
Reposted by Emmanuele Severi
evolvedbiofilm.bsky.social
Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community

bioRxiv from @fredebak.bsky.social et al #NNF_INTERACT

www.biorxiv.org/content/10.1...
Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community
The root microbiome is important for plant development. The impact of the root microbiome is the sum of multiple complex interactions among microorganisms, the plant and the environment. This complexi...
www.biorxiv.org
November 24, 2025 at 7:43 AM
emmseveri.bsky.social
#microsky #phagesky #phage

Anyone who’s tried deleting prophages in the lab by HR knows the difficulties of the task. Here we have an example of how HR-mediated natural transformation might hit the same hurdle in a more native context.

academic.oup.com/mbe/article/...
Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage
Abstract. Transformation occurs when bacteria import exogenous DNA via the competence machinery and integrate it into their genome through homologous recom
academic.oup.com
November 23, 2025 at 4:39 PM
Reposted by Emmanuele Severi
vivekmutalik.bsky.social
#phagesky #phage
November 22, 2025 at 4:01 AM
Reposted by Emmanuele Severi
plos.org
We are recruiting Academic Editors for our new journal, PLOS Aging and Health—a selective open science journal for research on developmental and age-related processes and changes across the life course.

➡️ Apply now: plos.io/48o1LQV
Promotional image for PLOS Aging and Health featuring a silhouette of three people walking on the beach at sunset with text inviting viewers to join their Editorial Board.
November 21, 2025 at 7:01 PM
Reposted by Emmanuele Severi
aharms485.bsky.social
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.

Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.

A thread 1/8
November 20, 2025 at 8:40 PM
emmseveri.bsky.social
#microsky #phagesky #phage defence
giusym1990.bsky.social Giusy Mariano @giusym1990.bsky.social · 4d
Excited to share our new study! Great fun working again with my good friend @stephenrgarrett.bsky.social — always a highlight! Huge thanks to fantastic co-authors @samkaytucker.bsky.social, @drandyjroe.bsky.social and our star technician Vojtech Pavelka. academic.oup.com/nargab/artic...
November 21, 2025 at 6:27 PM
Reposted by Emmanuele Severi
giusym1990.bsky.social
Excited to share our new study! Great fun working again with my good friend @stephenrgarrett.bsky.social — always a highlight! Huge thanks to fantastic co-authors @samkaytucker.bsky.social, @drandyjroe.bsky.social and our star technician Vojtech Pavelka. academic.oup.com/nargab/artic...
November 21, 2025 at 5:45 PM
emmseveri.bsky.social
#microsky #synbio

www.nature.com/articles/s41...
Semantic design of functional de novo genes from a genomic language model - Nature
By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined acti...
www.nature.com
November 21, 2025 at 1:25 PM
Reposted by Emmanuele Severi
vivekmutalik.bsky.social
www.nature.com/articles/s41...
Directed evolution of phages in biofilms enhances Pseudomonas aeruginosa control through improved lipopolysaccharide recognition - Nature Communications
Phage therapy holds potential against Pseudomonas aeruginosa chronic lung infections in cystic fibrosis patients. Here, the authors demonstrate that biofilm heterogeneity limits phage effectiveness an...
www.nature.com
November 21, 2025 at 8:45 AM
Reposted by Emmanuele Severi
vivekmutalik.bsky.social
#microsky

www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 21, 2025 at 8:40 AM
emmseveri.bsky.social
#microsky #phagesky

(Fancy!) transposon-insertion sequencing identifies essential genes in #phage. By @aharms485.bsky.social & Co.

www.biorxiv.org/content/10.1...
Systematic mapping of bacteriophage gene essentiality with HIDEN‑SEQ
The constant arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multid...
www.biorxiv.org
November 21, 2025 at 7:24 AM
emmseveri.bsky.social
#microsky #phagesky #phage
November 20, 2025 at 12:30 PM
Reposted by Emmanuele Severi
evolvedbiofilm.bsky.social
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates

-in @natcomms.nature.com

www.nature.com/articles/s41...
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications
Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...
www.nature.com
November 20, 2025 at 11:23 AM
Reposted by Emmanuele Severi
binomicalabs.org
Stowers group is hiring a bioinformatician with infrastructure experience focus (devops/pipes/annotation)

💻🧬

www.stowers.org/careers/bioi...
Bioinformatics Specialist (Infrastructure Focus) - REQID0002491
If you have a collection of outstanding people who ask really interesting questions, like each other and push the envelope, important discoveries will…
www.stowers.org
November 20, 2025 at 8:00 AM
emmseveri.bsky.social
#microsky

One more “missing link” ;-)

www.nature.com/articles/s41...
Rare microbial relict sheds light on an ancient eukaryotic supergroup - Nature
The discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic groups.
www.nature.com
November 20, 2025 at 6:03 AM
Reposted by Emmanuele Severi
stcmicrobeblog.bsky.social
published in 2018 and meanwhile seven years old(!), but still a highlight: wiggling 𝘝𝘪𝘣𝘳𝘪𝘰 𝘤𝘩𝘰𝘭𝘦𝘳𝘢𝘦 competence pilus catching DNA for uptake/transformation. found during the repair of our archive. written by @racheldiner.bsky.social . #MicroSky
Shin­ing a light on Vib­rio DNA up­take
by Rachel Diner — Vibrio cholerae is "kind of a big deal" in the bacterial world and a popular topic here on STC. Beyond being the causative agent for the disease cholera, it's a model bacterium f…
smallthingsconsidered.blog
November 19, 2025 at 5:53 PM
emmseveri.bsky.social
#microsky #phagesky

Structure of phage Ur-lambda

www.science.org/doi/10.1126/...
Structural basis of bacteriophage Ur-lambda infection initiation
In situ structures reveal molecular insights into infection initiation of bacteriophage Ur-lambda.
www.science.org
November 19, 2025 at 11:24 AM
emmseveri.bsky.social
#microsky

www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 19, 2025 at 8:16 AM