Laurie Parker
@llparker100.bsky.social
74 followers 100 following 54 posts
Chemical biLOLogist, proteomics enthusiast. MN 🔬🧪🧫 views expressed are my personal ones.
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llparker100.bsky.social
I don’t know enough about this stuff to know what is relevant here but just noticed that when scrolling through the HHS doc…
llparker100.bsky.social
The October 2025 doc says that (some part of to all of?) it does not apply to grants from NIH, refers to this link for the NIH Grants Policy Statement: grants.nih.gov/grants/polic...
grants.nih.gov
Reposted by Laurie Parker
science.org
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.

Learn more:
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases.
scim.ag
Reposted by Laurie Parker
rolanddunbrack.bsky.social
Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...
llparker100.bsky.social
It looks like a giant’s weird arm hair
Reposted by Laurie Parker
Reposted by Laurie Parker
gregggonsalves.bsky.social
Russell Vought wanted to shut down all extramural grants from NIH in this current fiscal year, putting stop to ALL research across the US. Someone in the White House had better sense. But Vought is a dangerous man, who will stop at nothing to destroy science in America. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
Reposted by Laurie Parker
drugmonkey.bsky.social
This NIH grant Multi-Year Funding ploy really makes you wonder what equally obscure and equally harmful stuff Vought is advancing across all the other functions of federal government, doesn’t it?
Reposted by Laurie Parker
llparker100.bsky.social
Hahah it helped explain to my lab how it means they will be able to fund way fewer projects moving forward.
llparker100.bsky.social
Where “you” in this scenario is the NIH institute leadership and your monthly rent is the annual budget for a given grant.
llparker100.bsky.social
It’s like if your landlord made you escrow your full lease period’s rent upfront. You would not then have money available to you to buy other stuff that whole time. You’d have way less available for groceries and would have to get very austere in any spending choices you make going forward.
Reposted by Laurie Parker
alice.soragnilab.com
This 4th percentile funding cutoff for the NCI is so very catastrophic. Assuming a 4th percentile payline corresponds to a ~5% success rate, it would take 27 grant submissions to have an 80% chance of getting just one funded. At the current submission cap of 6 apps as PI/year that means 4.5 years
Reposted by Laurie Parker
jeremymberg.bsky.social
NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.
Reposted by Laurie Parker
drugmonkey.bsky.social
"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year"
Reposted by Laurie Parker
drugmonkey.bsky.social
Talk about your grant lotteries. Earn a 4%ile for a chance at a four year award....or bupkis. whee.
llparker100.bsky.social
The 4th percentile… JFC
Reposted by Laurie Parker
altnih4science.bsky.social
There is a rally on MONDAY at 4:30 PM to stand up for NIH. Please join.

Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support.

actionnetwork.org/ev...
llparker100.bsky.social
Had such a good time at aps2025.org, so good to see everyone! A real community.
APS2025 – Peptides Rising
aps2025.org