Research shows germline genetic testing — testing for a cancer risk gene you may have inherited — can save lives. Not just a patient’s, but their family members, as well. Hereditary Cancer Awareness W...

This cohort study tests whether the oral bacterial and fungal microbiome is associated with the subsequent development of pancreatic cancer.

Introduction: Deficiency in BRCA genes leads to impediment in DNA repair and is associated with an increased lifetime risk of breast, ovarian, prostate, and pancreatic cancer and melanoma. Lynch synd...

Medullary breast cancer is a rare subtype of invasive breast cancer, representing from 0.2% to 6% of all breast carcinomas, with a higher proportion among women with triple-negative breast cancer and among those with a BRCA1 mutation. This review article aims to investigate the frequency of medullary breast cancer among all breast cancers and to assess its association with BRCA1 mutations. We surveyed studies involving patients diagnosed with breast cancer that report both the histology of the breast cancer as well as the presence of BRCA1 mutations. Among women with medullary breast cancer, the proportion of cases that carry a BRCA1 mutation ranges from 3% up to 35.3%, depending on the study. Among BRCA1-mutated breast cancers, the proportion that are medullary ranges from 8 to 20%. Given the notable association between medullary breast cancer and BRCA1 mutations, we propose to consider medullary breast cancer as a criterion for genetic testing in order to improve the identification of a larger number of carriers, thereby enhancing screening and prevention strategies.

This comparative effectiveness research study considers how to define clinical effectiveness from prospective cohort studies of women undergoing early salpingectomy with delayed oophortectomy vs salpi...

For years, I have been on the other side of the consultation table — guiding women through some of the most difficult decisions of their lives. As a breast oncoplastic surgeon, I have sat with mothers...

About three years ago, Stephanie Donati of DuBois was busy prepping her yard and outdoor furniture for the coming winter. But the aches and pains from...

This cohort study examines the prevalence of pathogenic or likely pathogenic variants in BRCA1 and BRCA2 in women with breast cancer in a racially and ethnically diverse population.

American voters might not have realized that a Republican victory in 2024 would mean sweeping cuts to cancer research, but that’s what they’re getting.

Facing healthcare’s uncertainty is better than avoiding it | Opinion

This week marks 50 years since tennis legend Chris Evert, 70, won her first U.S. Open Women’s Singles Title. As the worldwide tennis community honors her for her athletic prowess, her resilience as a ...

Patients with ovarian cancer who undergo BRCA testing face higher health care resource utilization (HCRU) and costs but are more likely to receive genomically targeted therapies and progress to later ...

Ovarian cancer may not be the most common or talked-about cancer, but like any major disease, it can turn your life upside down. While the…

Olympic gold medalist Shannon Miller says life after cancer is just another leg of “the journey” as recurring scans and monitoring your body inside and out once in remission. These regular check-ins c...

This study found that women who are BRCA mutation carriers are at higher risk for second primary ovarian/fallopian cancers if they have a prior history of breast cancer.

September is Ovarian Cancer Awareness Month, a time to spotlight a disease that remains one of the deadliest gynecologic cancers. To help raise awareness and share expert insights, Dr. Pedro T. Ramire...

The novel treatment was evaluated in a phase 2 trial and saw a clinical benefit in patients with advanced ovarian cancer.

Risk-reducing mastectomy is cost-effective for women aged 30 to 55 years who have a lifetime breast cancer risk of 35% or higher even if they are not carriers of a pathogenic gene variant.

the wake of the latest scandal he has perpetuated, National Nurses United, the nation’s largest nurses union and professional organization, today called for Robert F. Kennedy, Jr., the Secretary of He...

Justices rule lower court had no authority to compel restoration of more than 800 studies on diversity, transgender health, and other sensitive topics