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Lovorka Stojić

@loverna.bsky.social

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Lovorka Stojić @loverna.bsky.social · May 20

Join us for an in-person mini-symposium at @qmbci.bsky.social on July 16th to discuss several topics at the intersection of RNA biology and cancer. Free to come. Pizza and drinks to network @diunguyenvnuk.bsky.social @kevinrouault.bsky.social @rnasociety.bsky.social 👇👇

Reposted by Lovorka Stojić

QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · Jan 24

@blizardinstitute.bsky.social, @qmulepigenetics.bsky.social
is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.

QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · Jan 24

QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here
qmul-jobs.tal.net/vx/mobile-0/...

Lovorka Stojić @loverna.bsky.social · Jan 23

hopefully a good one! thank you

Lovorka Stojić @loverna.bsky.social · Jan 23

apologies for the quality of the images, I tried twice with the tutorial. If interested, please read the preprint- the quality of the images is much better! you can see that is the my 1st post here

Lovorka Stojić @loverna.bsky.social · Jan 23

thanks of taking care of me :-)

Lovorka Stojić @loverna.bsky.social · Jan 23

10/12 In sum, we identified RSRC2 as a new regulator of cell division & illustrated the importance of RNA-protein interactions in promoting error-free mitosis. I hope you like the tutorial and will enjoy reading our ms. #OpenAccess #OpenScience

Lovorka Stojić @loverna.bsky.social · Jan 23

9/12 But what about lncRNA C1QTNF1-AS1? Well, that was a challenging ❓ Since lncRNA did not affect RSRC2 splicing activity, we wondered whether it could affect RSRC2 moonlighting function in mitosis. We found that lncRNA regulates RSRC2 localisation on centrosomes.

Lovorka Stojić @loverna.bsky.social · Jan 23

8/12 But what is RSRC2 doing on centrosomes? RSRC2 is required for splicing of centrosomal proteins, such as PCNT & CDK5RAP2 & their recruitment on mitotic centrosomes. So mis-splicing of mitotic genes in RSRC2 KD cells is contributing to observed mitotic defects in these cells.

Lovorka Stojić @loverna.bsky.social · Jan 23

7/12 To understand how RSRC2 regulates splicing, we performed IP MS for RSRC2 and found that splicing and centrosome proteins are top RSRC2 interactors. Thus, RSRC2 is a multifunctional RBP.

Lovorka Stojić @loverna.bsky.social · Jan 23

6/12 Not much was known about RSRC2 when we started the project.... However, we found RSRC2 to be present in nuclear speckles and to regulate the splicing of mitotic regulators. This fits nicely with RSRC2 being present in Mitocheck and RBP2GO database.

Lovorka Stojić @loverna.bsky.social · Jan 23

5/12 We found that loss of lncRNA C1QTNF1-AS1 and RSRC2 protein mimic each other since their depletion causes defects in chromosome alignment and mitotic progression.

Lovorka Stojić @loverna.bsky.social · Jan 23

4/12 To understand how lncRNA C1QTNF1-AS1 regulates cell division, we set out to identify the proteins that C1QTNF1-AS1 interacts with and discover RSRC2, a protein with a poorly defined function.

Lovorka Stojić @loverna.bsky.social · Jan 23

3/12 How it all started? In our previous work, we identified lncRNA C1QTNF1-AS1, whose loss led to chromosome congression defects and mitotic delay, but we did not know how ❓❓❓

Lovorka Stojić @loverna.bsky.social · Jan 23

2/12 RSRC2 regulates mitotic fidelity through two distinct mechanisms: one associated with splicing of mitotic regulators and the other by localising to mitotic centrosomes, a function mediated by lncRNA C1QTNF1-AS1.

Lovorka Stojić @loverna.bsky.social · Jan 23

Thank you for all your input and suggestions!

Lovorka Stojić @loverna.bsky.social · Jan 23

Finally, huge thanks to our funders @bartscharity.bsky.social @cancerresearchuk.org @acmedsci.bsky.social @royalsociety.org and AIRC

Lovorka Stojić @loverna.bsky.social · Jan 23

11/12 Kudos to 1st authors Kaliya & Alice for their excellent teamwork @qmbci.bsky.social & everyone involved in this study @mardakheh.bsky.social and others not still on the otherside. Big 🙏 to all involved! #TeamWork

Lovorka Stojić @loverna.bsky.social · Jan 23

10/12 In sum, we identified RSRC2 as a new regulator of cell division & illustrated the importance of RNA-protein interactions in promoting error-free mitosis. I hope you like the tutorial and will enjoy reading our ms. #OpenAccess #OpenScience

Lovorka Stojić @loverna.bsky.social · Jan 23

📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis
www.biorxiv.org/content/10.1...

The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1

Mitotic fidelity depends on proper chromosome alignment at the spindle equator, a process known as chromosome congression, driven by well-established protein networks. Whereas RNA-binding proteins and...

www.biorxiv.org

Reposted by Lovorka Stojić

The Royal Society @royalsociety.org · Jan 22

The Royal Society's Newton International Fellowships are now open for applications. These fellowships are for non-UK early career scientists who wish to conduct research in the UK. Find out more, including how to apply: #RSGrants royalsociety.org/grants/newto...

Reposted by Lovorka Stojić

Miguel Branco @brancolab.bsky.social · Jan 21

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.

Postdoctoral Research Associate - QMUL Jobs

ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:

qmul-jobs.tal.net

Reposted by Lovorka Stojić

Miguel Branco @brancolab.bsky.social · Jan 9

CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching.
www.csh-asia.org?content/2544

Reposted by Lovorka Stojić

The Downs Lab @thedownslab.bsky.social · Dec 13

We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!

Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research

View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and exp...

Lovorka Stojić @loverna.bsky.social · Nov 26

Great postdoc opportunity on RNA in cancer!

Eleonora Leucci @leuccilrcb.bsky.social · Nov 26

We are looking for a postdoc to work on #lncRNAs, #translational regulation and #Cancer. If you are passionate, curious and able to work independently please consider to to e-mail me to discuss this further.