Lightnews — Scholar-powered news

Reposted by The Downs Lab

Aga Gambus @agagambus.bsky.social · 1d

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

Senior Research Technician at University of Birmingham

Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

13 8

Reposted by The Downs Lab

Rob Schneider @robertife.bsky.social · 16d

#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...

19 13

Reposted by The Downs Lab

puckknipscheer.bsky.social @puckknipscheer.bsky.social · 19d

Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs

1 10 13

Reposted by The Downs Lab

Di Antonio Research Group @diantoniogroup.bsky.social · 20d

We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇

www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

5 5

Reposted by The Downs Lab

Alexis Barr @alexisbarr.bsky.social · 20d

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

35 30

The Downs Lab @thedownslab.bsky.social · 22d

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs

www.cell.com/cell-reports...

7 14

Reposted by The Downs Lab

Zierhut Lab @zierlab.bsky.social · Aug 26

Great story from our fantastic neighbour Jörg Mansfeld!

Molecular Cell @cp-molcell.bsky.social · Aug 26

Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.

dlvr.it

5 13

The Downs Lab @thedownslab.bsky.social · Aug 25

Beautiful #pyrenees 😍. Totally refreshed and decompressed.

Wonder how long that will last....

2 1 17

The Downs Lab @thedownslab.bsky.social · Jul 18

Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉

1 13

The Downs Lab @thedownslab.bsky.social · Jul 10

You are on fire 🔥👏 🤩

1

The Downs Lab @thedownslab.bsky.social · Jul 4

Many of these were from the @icr.ac.uk conference, which was a great opportunity to catch up with colleagues. And drink beer.

Photo of people in the lab drinking beer

2 8

The Downs Lab @thedownslab.bsky.social · Jul 4

And @lillianwu.bsky.social presented a poster with her PhD thesis work on CENPB!

1 1 4

The Downs Lab @thedownslab.bsky.social · Jul 4

Alison also presented her work as a poster (and will be attending the upcoming AlterNat Biochem Soc meeting if anyone wants to hear more!)

1 1 4

The Downs Lab @thedownslab.bsky.social · Jul 4

@kezlane.bsky.social Karen Lane presented work she did with @susana-sousa.bsky.social and Noa Amin on ARID1A and G4s (not her main project - watch this space for a project coming out soon on cohesin dynamics in SWI/SNF deficient cells)

1 2 6

The Downs Lab @thedownslab.bsky.social · Jul 4

A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes

1 4 13

Reposted by The Downs Lab

ME Torres-Padilla @metorrespadilla.bsky.social · Jun 12

Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂

28 23

The Downs Lab @thedownslab.bsky.social · May 27

New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...

ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...

www.biorxiv.org

10 20

Reposted by The Downs Lab

Helfrid Hochegger @helfridh.bsky.social · May 21

Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you

url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...

PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex

At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.

url.uk.m.mimecastprotect.com

3 1

Reposted by The Downs Lab

Luijsterburglab @luijsterburglab.bsky.social · Apr 9

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

4 19 37

Reposted by The Downs Lab

The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

2 45 46

Reposted by The Downs Lab

Teif lab @teiflab.bsky.social · Mar 27

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025

Senior Research Officer at University of Essex

Searching for an academic job? Explore this Senior Research Officer opening on jobs.ac.uk! Click to view more details and browse other academic jobs.

www.jobs.ac.uk

20 9

The Downs Lab @thedownslab.bsky.social · Mar 19

Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...

Nobel prize-winning technology in cancer care - The Cancer Researcher

Katalin Karikó's work into mRNA vaccines

magazine.eacr.org

2 10

Reposted by The Downs Lab

stapleslab.bsky.social @stapleslab.bsky.social · Mar 12

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info

1 15 7

The Downs Lab @thedownslab.bsky.social · Mar 5

Thank you Ronan!

The Downs Lab @thedownslab.bsky.social · Mar 5

Thanks Christian!

1