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Reposted by Zierhut Lab

Aga Gambus @agagambus.bsky.social · 1d

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

Senior Research Technician at University of Birmingham

Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

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Reposted by Zierhut Lab

Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 19d

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research

View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral exp...

jobs.icr.ac.uk

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Reposted by Zierhut Lab

Elsässer Lab @simonelsasser.bsky.social · 19d

#Jobalert 🚨: looking for a #computationalbiology expert with track record in analysis, integration and interpretation of #omics datasets, in particular #epigenomics, #singlecellgenomics, #proteomics data. uni-freiburg.de/stellenangeb... short deadline 30th September!

Universität Freiburg

uni-freiburg.de

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Zierhut Lab @zierlab.bsky.social · 19d

🎉🎉🎉

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Reposted by Zierhut Lab

Alexis Barr @alexisbarr.bsky.social · 20d

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Zierhut Lab @zierlab.bsky.social · 27d

Academic research generates almost all intellecutal innovation in the life sciences. With big pharma refusing to contribute, maybe it's time to stop giving them our research outputs cheaply, and instead having globally nationalised means of translating innovation?
www.theguardian.com/business/202...

US drugmaker Merck scraps £1bn London research centre and cuts 125 science jobs

New blow to UK’s key life science sector as industry body says country is losing ground on investment and research

www.theguardian.com

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Zierhut Lab @zierlab.bsky.social · Sep 4

Congratulations!!

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Zierhut Lab @zierlab.bsky.social · Sep 3

Congratulations, Uli! Really interesting!

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Zierhut Lab @zierlab.bsky.social · Aug 26

Great story from our fantastic neighbour Jörg Mansfeld!

Molecular Cell @cp-molcell.bsky.social · Aug 26

Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.

dlvr.it

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Reposted by Zierhut Lab

Molecular Cell @cp-molcell.bsky.social · Aug 26

Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.

dlvr.it

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Zierhut Lab @zierlab.bsky.social · Aug 18

Excellent! See you there!

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Zierhut Lab @zierlab.bsky.social · Aug 16

Yes absolutely! You going to the Mechanobiology of the Nucleus meeting?

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Zierhut Lab @zierlab.bsky.social · Aug 15

Congratulations, Abby!

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Zierhut Lab @zierlab.bsky.social · Jul 3

Congrats Adrian! Cool to see this story develop with new and exciting results!

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Zierhut Lab @zierlab.bsky.social · Jun 27

Fantastic joint lab meeting day with @eileenparkes.bsky.social and Ben O'Leary plus our groups. Lots of cool science and discussions! And that fancy dinner at Lincoln College!

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Zierhut Lab @zierlab.bsky.social · Jun 27

It was such a great and inspirational day! Thank you very much for having us!

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Reposted by Zierhut Lab

Alessandro Costa @costalaboratory.bsky.social · Jun 20

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

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Zierhut Lab @zierlab.bsky.social · Jun 3

Fantastic news! Great to see this out now! Congratulations!

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Reposted by Zierhut Lab

Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Reposted by Zierhut Lab

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · May 29

Nice work by the Kurumizaka Lab in @natcomms.nature.com

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

www.nature.com/articles/s41...

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis - Nature Communications

The authors establish the ChIP-CryoEM method, which combines chromatin immunopurification coupled with cryo-electron microscopy, to visualize native human RNAPII elongation complexes in action, with a...

www.nature.com

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Reposted by Zierhut Lab

Alberto Ciccia @albertociccia.bsky.social · Apr 17

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...

DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect

High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...

www.sciencedirect.com

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Zierhut Lab @zierlab.bsky.social · Apr 10

Congrats! Looking forward to reading this!

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Zierhut Lab @zierlab.bsky.social · Apr 10

Cool! Looking forward to reading this!

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Zierhut Lab @zierlab.bsky.social · Mar 20

Thank *you*, Bungo! It was such a stimulating seminar, and great discussions!

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Zierhut Lab @zierlab.bsky.social · Mar 19

Congratulations!

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