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Mitotic single-stranded DNA suppression by DDIAS

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Reposted by Andrew Blackford

Daniel Durocher @durocher1.bsky.social · 28d

New work from the lab! 🔬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

Mitotic single-stranded DNA suppression by DDIAS

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Andrew Blackford @andrewblackford.bsky.social · 28d

See also the elegant and complementary study from the @durocher1.bsky.social lab, also out on bioRxiv: www.biorxiv.org/content/10.1...

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

Andrew Blackford @andrewblackford.bsky.social · 28d

Finally, we are particularly grateful to the patients and their families for their participation in this study.

Andrew Blackford @andrewblackford.bsky.social · 28d

The work was led by our star postdoc Kaima Tsukada & is the result of a great collaboration with labs of @fenaochs.bsky.social, @profstewartlab.bsky.social, @tcr-miller.bsky.social, @antonywoliver.bsky.social, Zafar Iqbal & others not on Bluesky.

Andrew Blackford @andrewblackford.bsky.social · 28d

We have also identified patients with bi-allelic mutations in DDIAS and CIP2A, who present with severe neurological phenotypes, revealing the pathological consequences of the failure to resolve DNA lesions during mitosis.

Andrew Blackford @andrewblackford.bsky.social · 28d

In brief: DDIAS is a mitosis-specific TOPBP1-binding protein that acts downstream of TOPBP1-CIP2A. DDIAS also has a ssDNA-binding domain, & mutation of this domain or loss of TOPBP1 binding leads to chromosomal breaks & micronuclei, as well as synthetic lethality in cells deficient in BRCA1 or BRCA2

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

Andrew Blackford @andrewblackford.bsky.social · 28d

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

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Andrew Blackford @andrewblackford.bsky.social · Aug 15

Congrats Beth, fantastic work!

Reposted by Andrew Blackford

Beth Psaila @bethpsaila.bsky.social · Aug 15

Thrilled that our paper is in print @science.org!!
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

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Reposted by Andrew Blackford

Jie Yang @jieyang437.bsky.social · Aug 4

One week left to apply for the postdoc position in my lab at Oxford @ox.ac.uk

Join our exciting cancer immunology research at @oncology.ox.ac.uk, @oxfordcancer.bsky.social & @oxcio.bsky.social.

Deadline: 11 August 2025 (noon).

Jie Yang @jieyang437.bsky.social · Jul 18

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.

Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...

Lab info: www.oncology.ox.ac.uk/team/jie-yang

Job Details

my.corehr.com

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Andrew Blackford @andrewblackford.bsky.social · Aug 1

Congratulations!

Postdoctoral Research Associate in the Blackford Group

Reposted by Andrew Blackford

Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Reposted by Andrew Blackford

Fena Ochs @fenaochs.bsky.social · May 6

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

Lundbeckfonden @lundbeckfonden.bsky.social · May 6

Stort tillykke til de nyligt udnævnte LF Fellows 2025!
Vi er glade for at kunne tildele vores LF #Fellowship til syv yderst talentfulde forskere.
Hver forsker modtager DKK 10 mio. til at støtte deres forskerprojekts udvikling over fem år. ow.ly/LKRh50VMYAP

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Reposted by Andrew Blackford

Barbara Marte @barbmarte.bsky.social · Apr 15

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

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Reposted by Andrew Blackford

Luijsterburglab @luijsterburglab.bsky.social · Apr 9

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

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Andrew Blackford @andrewblackford.bsky.social · Feb 26

Congratulations Ernst, great to see your work in print. Predictomes is a fantastic resource for the field!

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Reposted by Andrew Blackford

Ernst Schmid @ernstschmid.bsky.social · Feb 26

Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...

Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this co...

www.cell.com

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Andrew Blackford @andrewblackford.bsky.social · Jan 9

Postdoctoral Fellow position available in the DDR Biology and Functional Genomics teams at AstraZeneca in Cambridge UK. Closing date: 30-Jan-2025 astrazeneca.wd3.myworkdayjobs.com/Emerging-Tal...

Postdoctoral Fellow – DNA Damage Response Inhibitor Sensitisation in Cancer

Postdoctoral Fellow – DNA Damage Response Inhibitor Sensitisation in Cancer The Discovery Centre, Cambridge Biomedical Campus, UK Competitive salary and benefits Introduction to role: Do you have expe...

astrazeneca.wd3.myworkdayjobs.com

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Reposted by Andrew Blackford

Andrew Deans @genomestability.bsky.social · Dec 4

Excited to see the final published form of this amazing @drewberry.bsky.social‬ animation of DNA repair go live! Watch your favourite friends BRCA1/2, RPA, RAD51, Exo1, BLM, PCNA, MRN, primase and DNA polymerase perform their recombination magic. Cool educational & scientific tool for our community.

Drew Berry wehi.tv @drewberry.bsky.social · Dec 4

Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs

DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

YouTube video by WEHImovies

youtu.be

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Andrew Blackford @andrewblackford.bsky.social · Dec 4

Congratulations Drew, beautiful animation!

Transcription-coupled repair of DNA–protein crosslinks

Reposted by Andrew Blackford

Chris Carnie @cjcarnie.bsky.social · Dec 2

Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.

www.cell.com/trends/cell-...

DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple human diseases. They are caused by various endogenous and environmental agents, and from the actions of enzymes...

www.cell.com

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Reposted by Andrew Blackford

marcelvanvugt.bsky.social @marcelvanvugt.bsky.social · Nov 30

Happy to share our study by Francien Talens and many colleagues on RAD51 foci formation as a functional marker for PARPi sensitivity in ovarian cancer PDX models. academic.oup.com/narcancer/ar...

RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models

Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at

academic.oup.com

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Andrew Blackford @andrewblackford.bsky.social · Nov 28

Beautiful work Alessandro & team, congratulations to all the authors!