Lightnews — Scholar-powered news

Chris Carnie @cjcarnie.bsky.social · Aug 11

Really cool work from our KiTZ colleagues!

Grünewald Lab @grunewaldlab.bsky.social · Aug 11

Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

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Chris Carnie @cjcarnie.bsky.social · Jul 29

Congrats Román!

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Reposted by Chris Carnie

Julian Stingele @jstingele.bsky.social · Jul 21

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

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Reposted by Chris Carnie

Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Chris Carnie @cjcarnie.bsky.social · Jun 13

Reminds me of a line in Hannibal: ‘Trade? How does that word taste to you, Clarice? Cheap and metallic, like sucking on a greasy coin?’

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Reposted by Chris Carnie

Lucas Pontel @lucpontel.bsky.social · Jun 5

🚨 Check out our latest review in #MolecularCell!

We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis.

👏 Outstanding work by our talented PhD Std #MartaValverde @carrerasijc.bsky.social

👉📰
authors.elsevier.com/a/1lDFm3vVUP...

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Reposted by Chris Carnie

Andreas Panagopoulos @apanagopoulos.bsky.social · May 21

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

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Chris Carnie @cjcarnie.bsky.social · May 14

Cool, looking forward to reading this! Congratulations alln

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Chris Carnie @cjcarnie.bsky.social · May 14

A PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast!

karriere.klinikum.uni-heidelberg.de/index.php?ac...

PhD position in the biology and treatment of Osteosarcoma (m/f/d)

Pflichtfelder sind mit einem (*) markiert.

karriere.klinikum.uni-heidelberg.de

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Chris Carnie @cjcarnie.bsky.social · Apr 30

There’s something fishy about this plot

Reposted by Chris Carnie

spjacksongroup.bsky.social @spjacksongroup.bsky.social · Apr 10

Exciting opportunity for a suitably qualified individual to join us, www.jobs.cam.ac.uk/job/50998/

Research Assistant (Jackson Group) (Fixed Term) - Job Opportunities - University of Cambridge

Research Assistant (Jackson Group) (Fixed Term) in the Cancer Research UK Cambridge Institute at the University of Cambridge.

www.jobs.cam.ac.uk

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Reposted by Chris Carnie

Mekhail Lab at U. Toronto 🍁🇨🇦 @karimmekhail.bsky.social · Mar 18

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬

📖 Free access: rdcu.be/edViW

Please 🔄 ❤️

Nuclear and genome dynamics underlying DNA double-strand break repair

Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

rdcu.be

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Reposted by Chris Carnie

Julian Stingele @jstingele.bsky.social · Feb 20

Happy to share our review on the cellular responses to RNA damage 🥂

Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social

www.cell.com/cell/fulltex...

Cellular responses to RNA damage

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

www.cell.com

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Reposted by Chris Carnie

keithcaldecott.bsky.social @keithcaldecott.bsky.social · Feb 10

Dear all,

Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]

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Reposted by Chris Carnie

keithcaldecott.bsky.social @keithcaldecott.bsky.social · Dec 3

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on [email protected]

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Chris Carnie @cjcarnie.bsky.social · Dec 2

It’s a cynical ploy to make you buy their UBE2T aftersun

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Chris Carnie @cjcarnie.bsky.social · Dec 2

As a side note: kudos to the many people who gave us the nice flood of STK19 papers that were published just in time for us to cite the final articles rather than the preprints!

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Chris Carnie @cjcarnie.bsky.social · Dec 2

Big thanks to Ilaria Carnevale, the team at Trends in Cell Biology, and to the reviewers for their constructive input.

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Chris Carnie @cjcarnie.bsky.social · Dec 2

Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.

www.cell.com/trends/cell-...

Transcription-coupled repair of DNA–protein crosslinks

DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple human diseases. They are caused by various endogenous and environmental agents, and from the actions of enzymes...

www.cell.com

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Chris Carnie @cjcarnie.bsky.social · Nov 29

I'd hope that they're only showing the awardees once as 7/800 is even worse that 13! But yes, confusing representation...

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Chris Carnie @cjcarnie.bsky.social · Nov 29

Must be cumulative? Still, 13/800 is also pretty grim.

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Reposted by Chris Carnie

Julian Stingele @jstingele.bsky.social · Nov 28

Happy to share our latest work🍾 🥳

PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · Nov 28

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1

The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslink

www.biorxiv.org

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Chris Carnie @cjcarnie.bsky.social · Nov 27

I'd venture an 'an excitation'

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Reposted by Chris Carnie

Matthew Freeman @mjafreeman.bsky.social · Nov 15

Your chance to join one of the best labs in the field!

Great supervisor, great project

Sadly, I'm too old

adam grieve @adamgrieve.bsky.social · Nov 15

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

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Reposted by Chris Carnie

adam grieve @adamgrieve.bsky.social · Nov 15

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

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