Lightnews — Scholar-powered news

Fena Ochs @fenaochs.bsky.social · 14d

Congratulations, Cees! Well deserved 🎉

Reposted by Fena Ochs

Emilia Dimitrova @edimitrova.bsky.social · 29d

Double celebration on our floor @oxfordbiochemistry.bsky.social with @guifengwei.bsky.social from the Brockdorff lab and Dounia and Sherry from Fisher lab having their papers published today! And I hear there is more to come...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics - Nature Structural & Molecular Biology

Wei et al. show that the primary function of m6A on the nuclear long noncoding RNA Xist, a master regulator of X inactivation, is to promote RNA degradation. Xist turnover is mediated by the nuclear e...

www.nature.com

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Fena Ochs @fenaochs.bsky.social · 28d

Delighted to share our lab's first preprint identifying DDIAS as a mitotic DNA repair protein. Great collaboration with the @andrewblackford.bsky.social, @tcr-miller.bsky.social and @profstewartlab.bsky.social labs, and many more. Read the paper here: www.biorxiv.org/content/10.1...

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

www.biorxiv.org

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Reposted by Fena Ochs

Daniel Durocher @durocher1.bsky.social · 28d

New work from the lab! 🔬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

Mitotic single-stranded DNA suppression by DDIAS

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

www.biorxiv.org

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Reposted by Fena Ochs

Andrew Blackford @andrewblackford.bsky.social · 28d

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

www.biorxiv.org

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Reposted by Fena Ochs

Ting Wu Lab @tingwu-lab.bsky.social · Aug 13

What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.

Johannes Stein @jmstein.bsky.social · Aug 13

(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!

Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵

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Reposted by Fena Ochs

Duxin lab @duxinlab.bsky.social · Aug 22

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

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Reposted by Fena Ochs

Rebecca Berrens @rberrens.bsky.social · Jul 16

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols

Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

doi.org

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Fena Ochs @fenaochs.bsky.social · Jul 17

Congratulations @rberrens.bsky.social !!

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Fena Ochs @fenaochs.bsky.social · Jul 12

Thank you, Nadia!

Fena Ochs @fenaochs.bsky.social · Jul 12

I am happy to share that I have been nominated as Eppendorf Award 2025 finalist. It was a wonderful award ceremony, especially as this year's keynote speaker was Professor Sir Steve Jackson, who won the first Eppendorf Award in 1995.
Read more about the event here: lnkd.in/dcRsH3gg

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Reposted by Fena Ochs

Andrew Blackford @andrewblackford.bsky.social · May 29

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

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Fena Ochs @fenaochs.bsky.social · May 6

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

Lundbeckfonden @lundbeckfonden.bsky.social · May 6

Stort tillykke til de nyligt udnævnte LF Fellows 2025!
Vi er glade for at kunne tildele vores LF #Fellowship til syv yderst talentfulde forskere.
Hver forsker modtager DKK 10 mio. til at støtte deres forskerprojekts udvikling over fem år. ow.ly/LKRh50VMYAP

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Fena Ochs @fenaochs.bsky.social · Apr 21

Done!

Reposted by Fena Ochs

Lothar Schermelleh @lschermelleh.bsky.social · Apr 16

All you nuclear biologists out there: Here is a cautionary tale not to be fooled by peripheral organelle staining. It might just be that your antibody got trapped because it is "too good".

Konrad Chudzik @konrad-chudzik.bsky.social · Apr 14

🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...

Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics

Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...

doi.org

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Reposted by Fena Ochs

Job Dekker @jobdekker.bsky.social · Apr 11

Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!

Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!

With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.

See thread below:

Anton Goloborodko @golobor.bsky.social · Apr 11

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...

Rules of Engagement

YouTube video by Johan Gibcus

www.youtube.com

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Reposted by Fena Ochs

Anton Goloborodko @golobor.bsky.social · Apr 11

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...

Rules of Engagement

YouTube video by Johan Gibcus

www.youtube.com

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Reposted by Fena Ochs

The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

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Reposted by Fena Ochs

Duxin lab @duxinlab.bsky.social · Mar 25

🚨#CBC is happening today!

Don’t forget—our next Chromosome Biology Club is today at 16:45 at the Biocenter! Three great speakers and exciting science await, followed by beer and pizza. See you there!

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Fena Ochs @fenaochs.bsky.social · Mar 25

Wonderful, thought-provoking review by Sir Adrian Bird on cohesin loop extrusion as disrupter of chromatin organisation rather than generator. Great read!

www.sciencedirect.com/science/arti...

Cohesin as an essential disruptor of chromosome organization

Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a…

www.sciencedirect.com

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Reposted by Fena Ochs

stapleslab.bsky.social @stapleslab.bsky.social · Mar 12

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info

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Reposted by Fena Ochs

Anders Sejr Hansen @andersshansen.bsky.social · Feb 27

This is such a cool paper!

Pedro Rocha @pedroprocha.bsky.social · Feb 26

Here is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development.

Loss of a single CTCF motif is sufficient to cause embryonic lethality.

www.sciencedirect.com/science/arti...