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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 12d

Yes ! Drive and intelligence more important than experience.

Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 19d

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research

View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral exp...

jobs.icr.ac.uk

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

derek guy @dieworkwear.bsky.social · Aug 29

RFK Jr. taps his top deputy, Jim O’Neill, to be the new CDC director. Both men appear to wear skinny ties from Otaa. Otaa's ties are made in China from microfiber, a kind of plastic that, under the right conditions, can migrate to your balls.

A photo of Jim O'Neil getting sworn in by RFK Jr. You can see a close-up of his tie.

The same tie on Otaa's website. The site shows the tie is made from 100% microfiber.

The label for Otaa'a ties. It says "Designed in Australia."

The back of the label. It says "100% Microfiber. Hand Made Made in China"

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Sarah Moser @sarahmoser.bsky.social · Aug 13

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

www.nature.com

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Jul 30

our bit funded by @breastcancernow.bsky.social @cancerresearchuk.org and carried out @icr.ac.uk

Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Jul 30

With super Roman Chabanon and Sophie Postal Vinay, we show that inhibition of RNA editor ADAR1 causes a new form of BRCA synthetic lethality>autocrine inferferon poisoning. Relevant for ADAR1 drug discovery. Could provide a mechanistically different approach than PARPi. rdcu.be/eyo6t

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers

Nature Communications - The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the...

rdcu.be

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Jul 30

With super Roman Chabanon and Sophie Postal Vinay, we show that inhibition of RNA editor ADAR1 causes a new form of BRCA synthetic lethality>autocrine inferferon poisoning. Relevant for ADAR1 drug discovery. Could provide a mechanistically different approach than PARPi. rdcu.be/eyo6t

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers

Nature Communications - The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the...

rdcu.be

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Paperpile @paperpile.com · Jul 9

Academic writing is a craft. ✍️

You’re not born knowing how to write great papers, succinct emails, or convincing proposals. You get better by doing it badly, then better, then well.

Your writing is the first thing people see before they meet you. Make it count.

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Jun 27

This is fascinating:

Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · Jun 26

This is cool. An archaeal species with no metabolic genes. Just replicative genes (ribosomes, messenger and transfer RNAs). 238kb genome.

www.biorxiv.org/content/10.1...

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Jun 19

Watch this space: Stephen is going to do great things with this funding from the Lister Institute.

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Stephen John Sammut @stephensammut.bsky.social · Jun 19

Incredibly humbled and honoured to have been awarded the 2025 Research Prize from @thelisterinstitute.bsky.social. ❤️

🧬 We’re harnessing high-resolution molecular profiling + AI to uncover how cancer disables the immune system and find ways of restoring it. @icr.ac.uk

#bcsm #ai #CancerResearch

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Jun 19

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Francesco Iorio @francescoiorio.bsky.social · Jun 11

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Francesco Iorio @francescoiorio.bsky.social · Jun 11

Following the success of the first European Cancer Dependency Map Symposium in 2023, we are excited to announce the 2nd edition, to be held at Human Technopole on the 20th November 2025. Registration and Poster submission now open!
humantechnopole.it/en/trainings...
youtu.be/x2erCuovGvc
#EuroDepMap

1st European Cancer Dependency Map Symposium

YouTube video by Human Technopole

youtu.be

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · May 14

Loving “pertomics”. Going to push the term “buffomics” too.

Colm Ryan @colmr.bsky.social · May 14

congrats to @maxbillmann.bsky.social on making 'pertomics' an official published term www.embopress.org/doi/full/10....

Who controls the tariffs of a human cell? | Molecular Systems Biology

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · May 3

www.fiercebiotech.com/biotech/uk-u...

UK unveils £1B plan to become leading cancer research hub just outside the Golden Triangle

The United Kingdom aims to boost its life sciences profile as Aviva Capital Partners and Socius unveiled plans for a £1 billion ($1.3 billion) cancer research and manufacturing hub on the outskirts | ...

www.fiercebiotech.com

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Apr 25

We're looking for a Scientific Operations Project Manager
to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...

Scientific Operations Project Manager in Chelsea | The Institute of Cancer Research

View details and apply for this Scientific Operations Project Manager vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and experience. Future p...

jobs.icr.ac.uk

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Apr 16

pubmed.ncbi.nlm.nih.gov/28535155/

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

The OncoAlert Network 🚨 @oncoalert.bsky.social · Apr 11

The OptiTROP-Breast01 phase 3 trial evaluated sacituzumab tirumotecan (sac-TMT) versus chemotherapy in patients with heavily pretreated, locally recurrent or metastatic triple-negative #BreastCancer

www.nature.com/articles/s41...

✅Sac-TMT significantly improved progression-free survival PFS

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Barbara Marte @barbmarte.bsky.social · Apr 15

showing true (!) synthetic lethality
www.nature.com/articles/nat... www.nature.com/articles/nat...

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy - Nature

The discovery that BRCA1/2 mutant cells (defective in the homologous recombination pathway of DNA repair) are spectacularly sensitive to inhibition of the enzyme PARP (involved in base excision repair...

www.nature.com

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Barbara Marte @barbmarte.bsky.social · Apr 15

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Apr 14

Interested in starting your cancer research career in London ?We're looking for a Scientific Officer to support our work on synthetic lethality in triple negative and BRCA1/2 mutant cancers. Ideal job for a new graduate who wants to kick start their research career. jobs.icr.ac.uk/vacancies/12...

Scientific Officer - Target Validation and DNA Damage Response Group (Prof Andrew Tutt) in Chelsea | The Institute of Cancer Research

View details and apply for this Scientific Officer - Target Validation and DNA Damage Response Group (Prof Andrew Tutt) vacancy in Chelsea . Salary : Commencement on the salary range is s...

jobs.icr.ac.uk

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Apr 11

And Elvis 75 the best single never released

Andy Lewis @andylewis.bsky.social · Apr 11

Boys Wonder. Still the best band you’ve never heard of

Boys Wonder on stage at Village Underground

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Serena Nik-Zainal @serenanikzainal.bsky.social · Apr 10

PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻

A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet

Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)

Tweetorial below!! 👇

1/n

www.nature.com/articles/s41...

A redefined InDel taxonomy provides insights into mutational signatures - Nature Genetics

This paper describes a framework for classifying small insertions and deletions from genomic data and applies it to a large dataset comprising seven tumor types. The analysis highlights new insertion ...

www.nature.com

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Apr 11

www.bbc.co.uk/news/article.... Excellent news for breast cancer patients, based on great work from ICR scientists including our own Nick Turner.

New pill can slow progression of incurable breast cancer

Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.

www.bbc.co.uk

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Reposted by Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research

Luijsterburglab @luijsterburglab.bsky.social · Apr 9

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · Apr 4

We had the most fantastic joint lab retreat with our friends @josjonkers.bsky.social and Sabine Linn and their super smart colleagues @nkinl.bsky.social. The start of a lot of collaborative work targeting HRD and ILC.

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