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Helfrid Hochegger @helfridh.bsky.social · 1d

I would if I didn’t have a job already:-) super interesting project and great lab to work in!

Reposted by Helfrid Hochegger

Alexis Barr @alexisbarr.bsky.social · 1d

Just over one week until this opportunity closes!

If you’re an ambitious computational scientist looking for a Postdoc position, apply now

Alexis Barr @alexisbarr.bsky.social · 20d

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Helfrid Hochegger

Mcclelland lab @mcclellandlab.bsky.social · 6d

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

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Reposted by Helfrid Hochegger

Mathew Jones @jonesmjk.bsky.social · 14d

Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.

Andrew Deans @genomestability.bsky.social · 14d

Australian Cell Cycle, DNA repair and Telomere meeting draft schedule is now online!
Join us with 5 plenary speakers, 16 invited national speakers, 22 selected speakers, 61 poster presenters and lots and lots of fun science. Less than one month to go.
australiancellcycle.org/draft-schedu...

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Reposted by Helfrid Hochegger

Aaron Straight @astraight.bsky.social · Aug 18

@currentbiology.bsky.social has always been one of my favorite journals but I think they have now outdone themselves www.cell.com/current-biol.... And picked up by the @nytimes.com as well! www.nytimes.com/2025/08/18/s...

Periodic excretion patterns of seabirds in flight

Uesaka and Sato report on the excretion patterns of seabirds in the open ocean determined using a rear-facing video logger.

www.cell.com

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Helfrid Hochegger @helfridh.bsky.social · 18d

As universities, we need to do better!

What resources does your institution provide? What more should we be doing?

Thanks to @restispolitics.bsky.social for raising this!

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Helfrid Hochegger @helfridh.bsky.social · 18d

As students come back to campus in the UK, 8% of female students are likely to experience rape during their undergraduate years, especially in the first months of their studies.

revoltsexualassault.com/wp-content/u...

revoltsexualassault.com

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Reposted by Helfrid Hochegger

Alexis Barr @alexisbarr.bsky.social · 20d

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Helfrid Hochegger

Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 19d

We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...

PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research

View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral exp...

jobs.icr.ac.uk

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Helfrid Hochegger @helfridh.bsky.social · 25d

Beautiful work! Congrats.

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Reposted by Helfrid Hochegger

A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 29d

Thanks for sharing our work @bladoux.bsky.social (you just made the lead author @marcoenriquez18.bsky.social very happy 😊)

Benoit Ladoux @bladoux.bsky.social · Sep 4

Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions | Science Advances www.science.org/doi/10.1126/...

Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions

This work demonstrates that changes in the nonlinear elasticity of collagen in hybrid networks tunes cell-matrix interactions.

www.science.org

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Reposted by Helfrid Hochegger

Jasmeen Oberoi @jasmeenoberoi.bsky.social · Sep 4

Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸

Blood cancer awareness month. Image from Blood Cancer UK campaign. "It takes Science and Stubbornness".

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Reposted by Helfrid Hochegger

Mathew Jones @jonesmjk.bsky.social · Sep 1

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

rdcu.be

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Reposted by Helfrid Hochegger

Mike Lee @theleelab.bsky.social · Aug 15

I’m excited to highlight our latest paper, just published in Cell 🎉

We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.

1/n 🧪

www.cell.com/cell/fulltex...

RNA Pol II inhibition activates cell death independently from the loss of transcription

When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...

www.cell.com

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Reposted by Helfrid Hochegger

Antony W. Oliver (Tony) @antonywoliver.bsky.social · Aug 30

... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 27

#NEW_PAPER

In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).

rdcu.be/eCGxF

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...

rdcu.be

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Helfrid Hochegger @helfridh.bsky.social · Aug 28

Fantastic team effort led by Robert Zach.
Special thanks to @CR_UK and @wellcometrust for support and the many other authors to make this collaboration possible 🙏. Happy to discuss the work - comments and questions welcome!

Helfrid Hochegger @helfridh.bsky.social · Aug 28

Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications

The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…

www.nature.com

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Reposted by Helfrid Hochegger

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · May 23

We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply:
www.sussex.ac.uk/study/fees-f...

Life Sciences PhD Genome Stability - Understanding and Targeting Cell Cycle Control in Cancer : University of Sussex

www.sussex.ac.uk

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Helfrid Hochegger @helfridh.bsky.social · May 21

Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you

url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...

PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex

At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.

url.uk.m.mimecastprotect.com

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Reposted by Helfrid Hochegger

Adrian Saurin @adesaurin.bsky.social · Apr 1

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.

www.nature.com/articles/s41...

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications

Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...

www.nature.com

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Reposted by Helfrid Hochegger

Sean Carroll @seanmcarroll.bsky.social · Mar 28

Lovely retrospective for Dan Dennett.

Philosophy Talk @philtalkradio.bsky.social · Mar 28

The late Daniel Dennett was born on this date in 1942. After his passing last spring, we put together a special retrospective episode with his friend and admirer, Jenann Ismael from @jhuartssciences.bsky.social: www.philosophytalk.org/shows/daniel... #PhilSky #philosophy

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Helfrid Hochegger @helfridh.bsky.social · Feb 5

Zotero is the way

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Reposted by Helfrid Hochegger

Anthony Chalmers @profajchalmers.bsky.social · Jan 18

Thanks to the @simplyoncology.bsky.social guys for this opportunity to talk about everything high grade glioma!

John McGrane @jmcgrane.bsky.social · Jan 16

🎙️Out tomorrow on The Simply Oncology Podcast🎙️
We discuss High Grade Gliomas with the superb Professor Anthony Chalmers 🎙️
🚨Part 1 of 2 and we discuss implications of new molecular profiling on prognosis and treatment options.
@simplyoncology.bsky.social @profajchalmers.bsky.social

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Reposted by Helfrid Hochegger

Fillip Port @crisprflydesign.bsky.social · Jan 3

Interesting 🧵 about publishing in Math.

tl;dr: All papers in Math are preprinted. When publishers ask big $ for subscriptions or OA, mathematicians simply say "No thanks, we read these papers already on arXiv." Publishers then force unis to buy Math journals by bundling them with Bio journals.

Matthis @ Real Scientists DE @realscientists.de · Dec 31

Mathematik ist ein kleines Feld und hat oft eigene Lösungen, die besser sind als was gemeinhin passiert. Heute zum Abschluss will ich das am Beispiel von #OpenAccess vorführen. Die ganze OA Verschiebung hat der Mathe im wesentlichen Verschlechterungen gebracht. Warum? 🧵

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Reposted by Helfrid Hochegger

Adam Frank @adamfrank4.bsky.social · Dec 27

Here is my deep dive into Life, the Universe and Everything with Lex Fridman.

Discussions include Astrobiology, Technosignatures, the Physics of Life, Quantum Mechanics and the Philosophy of Science.

Big fun 3 hr + conversation.

www.youtube.com/watch?v=yhZA...

Adam Frank: Alien Civilizations and the Search for Extraterrestrial Life | Lex Fridman Podcast #455

YouTube video by Lex Fridman

www.youtube.com

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