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Reposted by Di Antonio Research Group

Di Michele Lab @dimichelelab1.bsky.social · 9d

Hey! Some group members and I are running a 10k race in Cambridge this Sunday, and raining some funds for @mdukcharity.bsky.social

Please donate and share!
@ceb.cam.ac.uk @pembroke1347.bsky.social

sportsgiving.co.uk/sponsorship/...

SportsGiving - Entry: Lorenzo Di Michele

Lorenzo Di Michele is fundraising for charity. Visit their fundraising page to sponsor them online now!

sportsgiving.co.uk

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Di Antonio Research Group @diantoniogroup.bsky.social · 8d

Have fun guys and leave nothing behind! push push push!

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Di Antonio Research Group @diantoniogroup.bsky.social · 20d

We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇

www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 27d

John Iredale kicking off our annual meeting. Auditorium is packed 😀 Record attendance!

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 26d

Thank you @beckyneuro.bsky.social @therad-lab.bsky.social and @thav-lab.bsky.social for kicking off our annual meeting with such inspiring insights from your research. Impressive examples of career-long commitment to a cause, opportunistic curiosity and always aspiration for clinical application 👏

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Prof. Zoë Waller @drzoewaller.bsky.social · Sep 6

Marco Di Antonio - his fantastic science is always challenging dogma, but first a bit about Italy ❤️ 🤌🤌🤌

@diantoniogroup.bsky.social

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Di Antonio Research Group @diantoniogroup.bsky.social · Sep 2

I would say that the expert on intrinsically toxic sequences is @costerlab.bsky.social

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Di Antonio Research Group @diantoniogroup.bsky.social · Aug 11

One of which is the HoD :)

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Emanuela Ruggiero @manuconlaccento.bsky.social · Aug 8

Proud to share our latest research in #NatureCommunication on #Gquadruplexes in #M_Tuberculosis as a new defense mechanism against oxidation
🔗https://www.nature.com/articles/s41467-025-62485-4
🧬🦠All-female collaboration from #DMM_Unipd
#SaraNRichter_ @irenezanin.bsky.social
#Tuberculosis

CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress - Nature Communications

In this study, the authors demonstrate that cleavage under targets and tagmentation (CUT&Tag) can be employed to map G-quadruplexes (G4s) in Mycobacterium tuberculosis, which may serve as pot...

www.nature.com

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Jul 30

Please share - this year's #ListerPrize is open for applications for another month!

🔎 Read about what winning it mean to some of our former Fellows like Dr Stineke Van Houte here: lister-institute.org.uk/what-it-mean...

🙋 Find out more about how to apply: lister-institute.org.uk/how-to-apply/

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Nucleic Acids Research @narjournal.bsky.social · Jul 28

⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa

Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di

doi.org

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Robert Hänsel-Hertsch @epistrucstab.bsky.social · Jul 28

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

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Di Antonio Research Group @diantoniogroup.bsky.social · Jul 24

Happy to share our latest preprint describing the first genome-wide mapping of G4s in T.Brucei, led by the amazing Ludovica Monti. We found that G4s accumulate in coding regions of the parasite, causing transcriptional perturbation upon treatment with G4-ligands.
www.biorxiv.org/content/10.1...

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions

G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei, the ca...

www.biorxiv.org

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Dillingham Lab @dillinghamlab.bsky.social · Jul 16

BBC News - Babies made using three people's DNA are born free of hereditary disease
www.bbc.com/news/article...

Babies from three people's DNA prevents heriditary disease

The method was pioneered by UK scientists to overcome devastating, sometimes fatal inherited diseases.

www.bbc.com

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RSC Nucleic Acids Group @rscnucleicacids.bsky.social · Jul 16

Congratulations to all the prize winners from the Nucleic Acids Forum 2025! An amazing selection of talks and posters to choose from! Thank you to our prize sponsors Chemgenes and RSC Chemical Biology!
@rscchembio.rsc.org
@mikeboothlab.bsky.social

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Nucleic Acids Research @narjournal.bsky.social · Jul 14

📣NAR Breakthrough Article!📣

✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊

📖 doi.org/10.1093/nar/...

#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics

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Di Antonio Research Group @diantoniogroup.bsky.social · Jul 14

Outstanding work, well done Mike it was an amazing day!

Michael Booth @drmikebooth.bsky.social · Jul 14

It was a privilege to organise the 2025 RSC Nucleic Acids Forum at Burlington House last week - @rscnucleicacids.bsky.social!

The NAF has been my favourite event every year, so it was amazing to run it myself!

Full crowd, fantastic talks and posters, and a wonderful community 🧬❤️

Me presenting my title slide for the event, with the wonderful sponsors!

an image of the ~130 attendees of the NAF!

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Di Antonio Research Group @diantoniogroup.bsky.social · Jul 14

Thank you for your constant support!
@thelisterinstitute.bsky.social

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Jul 14

Great paper from #ListerFellow Marco Di Antonio et al. G-quadruplex DNA appears to help ovarian cancer cells activate genes that shield them from chemotherapy. Drugs targeted to these structures re-sensitised the resistant cells to standard therapies.

Super work @diantoniogroup.bsky.social 🫶

Associate Professor Marco di Antonio leaning again a lab bench in his lab speaking with colleagues.

Head and shoulders photo of Lister Fellow Associate Professor Marco di Antonio.

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Di Antonio Research Group @diantoniogroup.bsky.social · Jul 13

Very pleased to see that The Observer has written a piece to cover our recent work in Genome Biology applied to ovarian cancer chemoresistance. Link below 👇👇👇
@theobserveruk.bsky.social
@imperialcollegeldn.bsky.social
@imperialchemistry.bsky.social

observer.co.uk/news/nationa...

observer.co.uk

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Di Antonio Research Group @diantoniogroup.bsky.social · Jul 12

Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf

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RSC Nucleic Acids Group @rscnucleicacids.bsky.social · Jul 11

Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬
@diantoniogroup.bsky.social

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RSC Nucleic Acids Group @rscnucleicacids.bsky.social · Jul 11

A big thank you to Mike Booth for organising this meeting! We have a great line-up for a very exciting day! Once again we would like to thank our sponsors for their support!
@drmikebooth.bsky.social

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RSC Nucleic Acids Group @rscnucleicacids.bsky.social · Jul 11

Our final speaker of the day is Thomas Maher from Imperial College London, presenting his work on the “Interrogation of the nuclear G quadruplex interactome through SG4directed proximity labelling“

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Yiliang Ding @yiliangding.bsky.social · Jul 11

@rscnucleicacids.bsky.social RSC nucleic acids new committee #2025NAF

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Yiliang Ding @yiliangding.bsky.social · Jul 11

Very honored to team up with @drmikebooth.bsky.social and @diantoniogroup.bsky.social to serve for the nucleic acids community @rscnucleicacids.bsky.social @rsc.org

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