Leticia Pérez
lperezsisques.bsky.social
Leticia Pérez
@lperezsisques.bsky.social
Reposted by Leticia Pérez
Here's the news piece from the IoPPN about our paper today! A wonderful way to end the year.

www.kcl.ac.uk/news/structu...
Structure of dopamine-releasing neurons relates to the type of circuits they form for smell-processing | King's College London
Closely related subtypes of dopamine-releasing neurons may play entirely separate roles in processing sensory information, depending on their physical structure.
www.kcl.ac.uk
December 16, 2025 at 11:11 AM
Reposted by Leticia Pérez
📣 New Pre-print from my lab to wrap-up year!!!

🎉 🎉 led by #GeorginaGoss with support from
@alejotorrescano.bsky.social @heathermwilson.bsky.social & @habkcl.bsky.social

Pairing #spatialtranscriptomics with #stemcell–derived #multilineage-organoids to elucidate human pancreatic islet development 💥
Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids https://www.biorxiv.org/content/10.64898/2025.12.13.694117v1
December 14, 2025 at 4:17 PM
Reposted by Leticia Pérez
Thrilled to see the work of my postdoc in the @labspagnoli.bsky.social finally published!
Many thanks to all the co-authors for all the help!
November 14, 2025 at 10:46 AM
Reposted by Leticia Pérez
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social

➡️ doi.org/10.1126/scia...

short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 3:56 PM
Reposted by Leticia Pérez
We are very happy to share with you this review pubished in @jneurochem.bsky.social @WileyGlobal.bsky.social . Very proud of all the students in the lab who contributed to craft this manuscript! EVs, mTOR and neuroinflammation. @ub.edu @ubneuro.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
Tiny Messengers, Huge Consequences: Extracellular Vesicles and mTOR Signaling in Neuroinflammation
Neuroinflammation is a crucial mediator in the pathogenesis of multiple neurodegenerative diseases, acting not only as a consequence but also as a driver of disease progression. Yet, much remains to ....
onlinelibrary.wiley.com
October 8, 2025 at 6:35 AM
Reposted by Leticia Pérez
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social

thenode.biologists.com/jobs/postdoc...
Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node
The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...
thenode.biologists.com
August 5, 2025 at 10:15 AM
Reposted by Leticia Pérez
We are doing it again!! 🚶‍♀️🚶‍♂️🚶🧪🧫🔬
For the Second Year My Lab is participating to the
One_Walk_London 🎡 to raise money for life-changing research & make a difference to T1D #diabetes
⤵️
support.breakthrought1d.org.uk/fundraisers/...

Please help us raise funds for @breakthrought1duk.bsky.social
Spagnoli Lab. One Walk
Please help us raise vital funds for Breakthrough T1D, the leading global type 1 diabetes (T1D) research charity. Your support will help change the lives of everyone affected with T1D - Thanks so much...
support.breakthrought1d.org.uk
June 2, 2025 at 11:36 AM
Reposted by Leticia Pérez
#RecercaUB | 🧠 Un equip de @ubneuro.bsky.social ha descobert nous mecanismes moleculars relacionats amb el declivi cognitiu associat a la malaltia d’Alzheimer.

🎓 N’és la primera autora Almudena Chicote, membre de l’equip de Cristina Malagelada, de @medicinacs-ub.bsky.social.
Nova descoberta sobre els factors relacionats amb la progressió de la malaltia d’Alzheimer
web.ub.edu
May 27, 2025 at 8:01 AM
Reposted by Leticia Pérez
I'm excited to share our latest work as senior author, published in Alzheimer's & Dementia
"Astrocytes, via RTP801, contribute to cognitive decline by disrupting GABAergic-regulated connectivity and driving neuroinflammation in AD"
Very proud of this team!

🧪 Read it here: doi.org/10.1002/alz....
May 7, 2025 at 10:01 AM
Reposted by Leticia Pérez
Reposted by Leticia Pérez
Happy to see the first bit of my postdoc work out! Have a look! 👀
🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !

Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas https://www.biorxiv.org/content/10.1101/2025.04.16.649169v1
April 18, 2025 at 10:49 AM
Reposted by Leticia Pérez
🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !

Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas https://www.biorxiv.org/content/10.1101/2025.04.16.649169v1
April 17, 2025 at 9:12 PM
Reposted by Leticia Pérez
An analysis of 20 autism mouse models point to two subtypes: One displaying out-of-sync brain activity and impaired synaptic pathways, the other with too much synchrony and dysregulated immune pathways.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/spectrum/too...
Too much or too little brain synchrony may underlie autism subtypes
Functional connectivity differences in autism mouse models point to two subtypes that correspond to patterns seen in some people with the condition.
www.thetransmitter.org
April 17, 2025 at 1:27 PM
Reposted by Leticia Pérez
Do you want to help as a technician in a transaltional project in the context of Alzheimer's disease? Yes, we are hiring. 2-year contract. This is a straightforward collaboration between CIRCE Scientific and Creatio UB. See the offer also at: www.linkedin.com/feed/update/...
April 15, 2025 at 7:08 AM