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Reposted by Alejo Torres

Christian Mosimann @chrmosimann.bsky.social · 14d

Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀

Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).

Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5

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Reposted by Alejo Torres

Sally Lowell @cellysally.bsky.social · 14d

Hot off the press!

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

www.nature.com/articles/s41...

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 - Nature Communications

Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.

www.nature.com

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Reposted by Alejo Torres

Sara Wickstrom @sarawickstrom.bsky.social · 15d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Alejo Torres

Silvia Fre lab @frelab.bsky.social · 15d

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Contractile fibroblasts form a transient niche for the branching mammary epithelium

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

rdcu.be

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Reposted by Alejo Torres

Arnau Sebé-Pedrós @arnausebe.bsky.social · 20d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

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Reposted by Alejo Torres

Denis Jabaudon @djabaudon.bsky.social · 26d

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

www.science.org

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Reposted by Alejo Torres

Daniel Drucker @danieljdrucker.bsky.social · Sep 10

A multi-omics overview of perturbations in the #T1D pancreas at the single cell level #islets www.science.org/doi/10.1126/...

Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression

Pancreatic cell types show changes in gene regulation and activity associated with T1D progression and risk.

www.science.org

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Reposted by Alejo Torres

Ollie Inge @oliveringe.bsky.social · Sep 9

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

www.cell.com

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Reposted by Alejo Torres

Rocio Sancho Lab @labsancho.bsky.social · Sep 8

Walking through the night for Cancer Research UK 🌙✨ Every step helps beat cancer 💜 Please support with a donation if you can 🙏💫
fundraise.cancerresearchuk.org/page/rocios-...

Rocio - Shine Night Walk

I am taking part in the Shine Walk in memory of my mother, who was my rock, the strongest guiding force in my life, who shaped who I am today and gave me the most powerful example to follow. She passe...

fundraise.cancerresearchuk.org

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Reposted by Alejo Torres

IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · Aug 16

🔬 Researchers at #IBEC record for the first time the real-time 3D implantation of a human embryo.

A major step forward in understanding fertility and improving assisted reproduction treatments.

👉 Published in @science.org #ScienceAdvances
🔗 Read the news: bit.ly/4oAHy0w

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Reposted by Alejo Torres

Kate Miroshnikova @katemiro.bsky.social · Aug 15

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

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Reposted by Alejo Torres

Richard Behringer @rrbehringer.bsky.social · Mar 26

12 examples of how developmental biology research led to fundamental discoveries for biomedical research. There are many more! Download ppt & jpg versions on @socdevbio.bsky.social website. Use & modify as needed. Poster formats are also posted to print & hang in your lab!

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Reposted by Alejo Torres

Toby Andrews @tobyandrews.bsky.social · Aug 6

Thrilled to bits to see our latest work online in Dev Cell! 🥳

We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n

tinyurl.com/cell-stretch

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

tinyurl.com

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Reposted by Alejo Torres

Karen J Liu @karenjliu.bsky.social · Aug 5

Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social

thenode.biologists.com/jobs/postdoc...

Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node

The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...

thenode.biologists.com

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Reposted by Alejo Torres

Amoyel lab @amoyellab.bsky.social · Jul 25

🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...

Somatic cells compartmentalise their metabolism to sustain germ cell survival

To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrie...

www.biorxiv.org

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Reposted by Alejo Torres

Joaquina Delas @joadelas.bsky.social · Jul 21

Excited to share our latest work with @jamesbriscoe.bsky.social .

A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord.

Congrats to all authors.

UCL Faculty of Life Sciences @ucllifesciences.bsky.social · Jul 21

A study from @crick.ac.uk and @ucllifesciences.bsky.social reveals how timing mechanisms, not just spatial cues, shape cell identity during spinal cord development. The findings open up new avenues for both basic developmental biology and clinical applications.
www.sciencedirect.com/science/arti...

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While t…

www.sciencedirect.com

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Reposted by Alejo Torres

PLOS Biology @plosbiology.org · Jul 16

Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org 🧪 plos.io/4lQMeNu

Patterning of cell identities in the posterior E8.5 mouse embryo. Co-expression of mesoderm marker TBXT (blue) and neural marker SOX2 (green) identifies cells in the neuromesodermal (NMP) progenitor region at the intersection of their respective gene expression gradients. TBX6 (red) marks paraxial mesoderm and also marks sporadic mesoderm-committed cells emerging within the NMP region. LAMINB1 (white) marks the nuclear envelope of all cells. Credit: Matthew French.

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Reposted by Alejo Torres

Robin Journot 🔬| 🎾 @robinjournot.bsky.social · Jul 1

🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at ‪
‪ @institutcurie.bsky.social

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Reposted by Alejo Torres

Vicki Metzis @vmetzis.bsky.social · Jun 27

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

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Colin Ratcliffe @colindhratcliffe.bsky.social · Jun 18

Organoids in a dish are next to one another. Treatment stops some of them from growing but their neighbours just keep going. What’s the difference? Hint: it’s not genetic

doi.org/10.1101/2025...

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Reposted by Alejo Torres

Camilla Autorino @cami-autorino.bsky.social · Jun 11

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨

“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶

🔗 www.biorxiv.org/content/10.1...

#devbio #biophysics

🧵⤵️

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Reposted by Alejo Torres

Nature @nature.com · Jun 4

Male mouse fetuses can develop female organs in utero if their mother is iron deficient during pregnancy

https://go.nature.com/43N7f4s

Male mice can grow ovaries if their pregnant mums are iron deficient

The study is the first to show that low iron levels can affect fetal sexual development.

go.nature.com

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Reposted by Alejo Torres

Spagnoli_Lab. @labspagnoli.bsky.social · Jun 2

We are doing it again!! 🚶‍♀️🚶‍♂️🚶🧪🧫🔬
For the Second Year My Lab is participating to the
One_Walk_London 🎡 to raise money for life-changing research & make a difference to T1D #diabetes
⤵️
support.breakthrought1d.org.uk/fundraisers/...

Please help us raise funds for @breakthrought1duk.bsky.social

Spagnoli Lab. One Walk

Please help us raise vital funds for Breakthrough T1D, the leading global type 1 diabetes (T1D) research charity. Your support will help change the lives of everyone affected with T1D - Thanks so much...

support.breakthrought1d.org.uk

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Reposted by Alejo Torres

Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · May 21

Our work on lineage tracing with somatic epimutations is finally out in @nature.com!

Check out the thread by @larsplus.bsky.social below.

EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere.

Detailed protocols coming out soon!

Lars Velten @larsplus.bsky.social · May 21

Out @nature.com: Clonal tracing with somatic epimutations

🧬 Single cell methylome encodes cell state & clonal identity

🔨 EPI-Clone reads out both (+mutations, +RNA) at scale

🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations

doi.org/10.1038/s415...
🧵

Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

doi.org

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Alejo Torres @alejotorrescano.bsky.social · Apr 18

Happy to see the first bit of my postdoc work out! Have a look! 👀

Spagnoli_Lab. @labspagnoli.bsky.social · Apr 17

🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !

Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Apr 17

Spatially organized cellular communities shape functional tissue architecture in the pancreas https://www.biorxiv.org/content/10.1101/2025.04.16.649169v1

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