Silvia Fre lab
@frelab.bsky.social
Developmental biologist interested in stem cell fate
Thank you @patrickpla.bsky.social ! I wish I could have been there this year #FSSCR2025
Very nice talk by Silvia Torchio from @frelab.bsky.social showing how ROS levels control cell fate decisions in intestinal organoids #FSSCR2025
November 19, 2025 at 12:00 PM
Thank you @patrickpla.bsky.social ! I wish I could have been there this year #FSSCR2025
Congratulations to Bruno Simoes and Rob Clarke! #ENBDC #breastcancer
Nature research paper: Anti-progestin therapy targets hallmarks of breast cancer risk
go.nature.com/4oSEBrg
go.nature.com/4oSEBrg
Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.
go.nature.com
November 11, 2025 at 11:41 AM
Congratulations to Bruno Simoes and Rob Clarke! #ENBDC #breastcancer
Thank you so much @doctoremmerson.bsky.social for liking our paper! Looking forward to discussing the implications with you!
A beautiful study describing cell fate acquisition in bilayered #epithelia, inc. my fave #salivarygland, published in @cp-devcell.bsky.social
Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration
www.cell.com/developmenta...
Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration
www.cell.com/developmenta...
Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration
Journot et al. explore fate specification during embryonic development and regeneration
of bilayered glandular epithelia. They uncover conserved molecular mechanisms linking
tissue architecture with c...
www.cell.com
October 27, 2025 at 12:48 PM
Thank you so much @doctoremmerson.bsky.social for liking our paper! Looking forward to discussing the implications with you!
Reposted by Silvia Fre lab
Our paper is on the cover of @cp-devcell.bsky.social . Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved.
doi.org/10.1016/j.de...
doi.org/10.1016/j.de...
October 6, 2025 at 7:38 PM
Our paper is on the cover of @cp-devcell.bsky.social . Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved.
doi.org/10.1016/j.de...
doi.org/10.1016/j.de...
Reposted by Silvia Fre lab
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids
Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.
journals.biologists.com
October 3, 2025 at 9:54 AM
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Contractile fibroblasts form a transient niche for the branching mammary epithelium
Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...
rdcu.be
September 29, 2025 at 4:34 PM
So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...
Geometry first: how positional cues dictate fate in bilayered epithelia - the Node
Behind the paper story focussed on research on early fate decisions in bilayered epithelia.
thenode.biologists.com
September 9, 2025 at 7:12 AM
Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...
Reposted by Silvia Fre lab
Super happy to share the work by my post-doc Candice Merle on breast cancer obtained @institutcurie.bsky.social thanks to funding from ARC:
www.fondation-arc.org/actualites/2...
www.fondation-arc.org/actualites/2...
Pour mieux comprendre la transformation cancéreuse des cellules mammaires
Une exploration des mécanismes moléculaires qui permettent aux cellules mammaires de modifier leur identité donne des éléments fondamentaux pour comprendre certains phénomènes de la transformation can...
www.fondation-arc.org
July 15, 2025 at 2:50 PM
Super happy to share the work by my post-doc Candice Merle on breast cancer obtained @institutcurie.bsky.social thanks to funding from ARC:
www.fondation-arc.org/actualites/2...
www.fondation-arc.org/actualites/2...
Reposted by Silvia Fre lab
🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at
@institutcurie.bsky.social
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at
@institutcurie.bsky.social
July 1, 2025 at 6:39 AM
🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at
@institutcurie.bsky.social
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at
@institutcurie.bsky.social
1000 congrats to Walid @wtklab.bsky.social !!! Plenty of success!
Could this be the future of cancer prevention?
Walid Khaled, a new ERC Advanced Grant recipient @cam.ac.uk, will work on a preventive vaccine for breast cancer.
Learn more 👉 buff.ly/s6cBCwL
#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social
Walid Khaled, a new ERC Advanced Grant recipient @cam.ac.uk, will work on a preventive vaccine for breast cancer.
Learn more 👉 buff.ly/s6cBCwL
#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social
June 17, 2025 at 11:34 AM
1000 congrats to Walid @wtklab.bsky.social !!! Plenty of success!
Beautiful and insightful review! Congrats to @sarawickstrom.bsky.social and @clemvilleneuve.bsky.social
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 12, 2025 at 12:18 PM
Beautiful and insightful review! Congrats to @sarawickstrom.bsky.social and @clemvilleneuve.bsky.social
March 7, 2025 at 4:58 PM
Reposted by Silvia Fre lab
This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth.
It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.
It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.
February 10, 2025 at 11:59 PM
This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth.
It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.
It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.
Reposted by Silvia Fre lab
JOB ALERT
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
January 15, 2025 at 2:54 PM
JOB ALERT
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
Reposted by Silvia Fre lab
The man in charge of social media platforms used by billions should show some moral courage, writes @jemima.bsky.social www.ft.com/content/682c...
January 13, 2025 at 5:44 AM
The man in charge of social media platforms used by billions should show some moral courage, writes @jemima.bsky.social www.ft.com/content/682c...