@lsoucek.bsky.social
SF was home for 10 years, and UCSF is where I trained and grew as a scientist. Grateful to bridge academia and biotech, past and present. #MYC #OMO103 #Biotech #TranslationalResearch
January 18, 2026 at 10:32 AM
SF was home for 10 years, and UCSF is where I trained and grew as a scientist. Grateful to bridge academia and biotech, past and present. #MYC #OMO103 #Biotech #TranslationalResearch
In parallel, I returned to @ucsfcancer.bsky.social, invited by @shulab2010.bsky.social, to give a talk on developing the first viable clinical #MYCinhibitor, #OMO-103, representing @vhio.bsky.social, @lsouceklab.bsky.social
and @icreacommunity.bsky.social.
and @icreacommunity.bsky.social.
January 18, 2026 at 10:32 AM
In parallel, I returned to @ucsfcancer.bsky.social, invited by @shulab2010.bsky.social, to give a talk on developing the first viable clinical #MYCinhibitor, #OMO-103, representing @vhio.bsky.social, @lsouceklab.bsky.social
and @icreacommunity.bsky.social.
and @icreacommunity.bsky.social.
Link to the article: www.cell.com/cell-reports...
MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
Giuntini et al. demonstrate that Omomyc, the only direct MYC inhibitor currently in
phase 2 clinical trials, causes DNA damage and synergizes with PARPis in triple-negative
breast cancer. Their findin...
www.cell.com
December 3, 2025 at 6:56 AM
Link to the article: www.cell.com/cell-reports...
Huge thanks to Fabio Giuntini, and to the entire teams at
@vhio.bsky.social and #peptomyc for making this possible. We also want to acknowledge the support of
#AECMM and the @erc.europa.eu for backing research that can make a real difference.
@vhio.bsky.social and #peptomyc for making this possible. We also want to acknowledge the support of
#AECMM and the @erc.europa.eu for backing research that can make a real difference.
December 3, 2025 at 6:56 AM
Huge thanks to Fabio Giuntini, and to the entire teams at
@vhio.bsky.social and #peptomyc for making this possible. We also want to acknowledge the support of
#AECMM and the @erc.europa.eu for backing research that can make a real difference.
@vhio.bsky.social and #peptomyc for making this possible. We also want to acknowledge the support of
#AECMM and the @erc.europa.eu for backing research that can make a real difference.
In triple-negative breast cancer (TNBC), #Omomyc/#OMO-103 shuts down DNA-repair gene programs, triggers DNA damage and — in combination with PARP inhibitors — restores response even in PARPi-resistant models.
December 3, 2025 at 6:56 AM
In triple-negative breast cancer (TNBC), #Omomyc/#OMO-103 shuts down DNA-repair gene programs, triggers DNA damage and — in combination with PARP inhibitors — restores response even in PARPi-resistant models.