A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoem

Thank you, Steve!

Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:

urldefense.com/v3/__https:/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social

Subtype-specific structural features of the hearing loss-associated human P2X2 receptor pubmed.ncbi.nlm.nih.gov/40938707/ #cryoem

Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket.

www.pnas.org/doi/10.1073/...

@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social

A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM

The KCVI research retreat was a great success this year.

Very happy to participate. Looking forward to making this an annual event!

Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing.

If you are interested, please watch a recording of his seminar, linked here:

youtu.be/IdcoLJc7X8M

Navigating the worlds of research and patient care requires both precision and passion, and @ohsunews.bsky.social's Dr. Steven E. Mansoor finds fulfillment in this work as a physician-scientist. ohsufoundation.org/stories/the-...

A paper from our group published a couple of months ago.

I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.