manubenjohny.bsky.social
Manu Ben-Johny
@manubenjohny.bsky.social
96 followers 180 following 2 posts
Ion channels, Ca2+, Biophysics, Engineer, Dad. Assistant Professor at Columbia
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olibclarke.bsky.social
Oli Clarke @olibclarke.bsky.social · Aug 30
Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.
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manubenjohny.bsky.social
Manu Ben-Johny @manubenjohny.bsky.social · Aug 20
Very excited to share our most recent work on using de novo design to custom engineer a small peptide that can restore proper sodium channel function in disease … to be able to “write” proteins to do whatever we want them to do, is just remarkable …
cp-cell.bsky.social
Cell - a Cell Press journal @cp-cell.bsky.social · Aug 18
Now online! De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
De novo protein design was used to engineer a peptide that reverses gain-of-function deficits in voltage-gated sodium channels linked to cardiac arrhythmia and epilepsy.
dlvr.it
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manubenjohny.bsky.social
Manu Ben-Johny @manubenjohny.bsky.social · Apr 14
Very excited to share our latest work on ways to tune S-Palmitoylation of proteins! We engineered Abhd17 enzymes to be chemically/optically activated. We can then use this to inhibit palmitoylation of specific proteins, many possibilities … Check it out!

www.nature.com/articles/s41...
Engineered depalmitoylases enable selective manipulation of protein localization and function - Nature Communications
Dynamic palmitoylation modulates protein localization and function. Here, Jayaraman et al develop a toolkit of engineered depalmitoylases to manipulate protein function with spatial, temporal, and substrate specificity.
www.nature.com
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