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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · 7d

October 1st, the start of one of my favorite months! One of my friends in IT made me this 3D printed brain 🧠 the spooky candies were a nice touch 🎃 #pathsky

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Sep 1

Have also seen it stain pilomatrix-like carcinoma and some gliomas (one with a BRAF mutation).

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Reposted by Maria Gubbiotti, MD,PhD

PathologyOutlines.com @pathologyoutlines.bsky.social · Jun 25

Image of the Week!

Submitted by: Gabrielle Yeaney, M.D.
Directory Profile: www.pathologyoutlines.com/directory/ga...
Subspecialty: Neuropathology
Diagnosis: Normal pineal gland

#Pathology #PathologyOutlines #NeuroPath #PathSky

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jun 13

Dural-based mass with dural tail

Negative for SSTR2, no evidence of STAT6 fusion, and strong CD56 staining

GLI1 amplification present

🧠 take home point: GLI1-altered mesenchymal tumors can occur in the CNS and radiologically mimic meningioma!

academic.oup.com/jnen/advance...

#pathsky

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Reposted by Maria Gubbiotti, MD,PhD

MD Anderson Cancer Center @mdanderson.bsky.social · Jun 9

MD Anderson research findings suggest that targeting interactions between some cells around the blood vessels could help make glioblastoma more vulnerable to treatment.

Read more: http://spr.ly/633204H8Uj #OncSky #EndCancer

Targeting cells that form blood vessels in glioblastoma could improve treatment

spr.ly

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Reposted by Maria Gubbiotti, MD,PhD

Caroline Brennan @txbraintrust.bsky.social · Apr 17

📣TOMORROW, Friday, April 18, 12 noon CST!📣

Join the Brain Tumor Center of the Cancer Neuroscience Program seminar series! 🧠

We’re talking liquid biopsies in CNS tumors with @MDAnderson.bdky.social pathologist Dr. Leomar Ballester.

Login details: Email [email protected]

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Apr 4

Superstar surgical pathology fellow Dr. William Mi was recognized with the Award for Clinical Excellence in Professionalism today! Congratulations to him for the well-deserved honor 🔬 #pathsky #medsky @mdanderson.bsky.social

A photo of Dr Mi wearing a white coat on the big screen

Dr Mi shaking hands with the award giver

Two pathologists taking a photo in front of a plant

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Reposted by Maria Gubbiotti, MD,PhD

MD Anderson Cancer Center @mdanderson.bsky.social · Feb 19

MD Anderson and Texas Children’s Hospital announce a transformational collaboration dedicated solely to pediatric cancer care. This new first-of-its-kind joint venture, which will launch in early 2026, has a single mission: to end childhood cancer. #EndCancer

UT MD Anderson and Texas Children’s Hospital Announce Joint Venture to End Childhood Cancer

bit.ly

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Feb 14

Yes they are!

Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Feb 11

In honor of upcoming Valentine’s Day here is a classic example of rosette-forming glioneuronal tumor. These grade 1 tumors typically show a hotspot mutation in FGFR1 along with PIK3R1 or PIK3CA alterations and are usually found in the fourth ventricle 🌹 ♥️ 🥀 🧠 🔬 #pathsky #neuropath #medsky

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Reposted by Maria Gubbiotti, MD,PhD

AndrewFolpe @folpe-mn-st.bsky.social · Feb 6

#PathSky 43F with a solitary lung mass. Relatively circumscribed, nests and interesting micropapillae of lightly eosinophilic epithelioid cells. Negative for everything except TFE3. Dx?

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Reposted by Maria Gubbiotti, MD,PhD

AndrewFolpe @folpe-mn-st.bsky.social · Feb 6

This is a clear cell stromal tumor of the lung. They have YAP1::TFE3 fusions, which are also present in YAP1::TFE3-fused hemangioendotheliomas and some pulmonary PEComas. Abbas Agaimy described these. pubmed.ncbi.nlm.nih.gov/33899786/

Recurrent YAP1-TFE3 Gene Fusions in Clear Cell Stromal Tumor of the Lung - PubMed

Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCST-L) is a recently described distinctive rare pulmonary neoplasm of unknown histogenesis and molecular pathogenesis. Only 7 cases have ...

pubmed.ncbi.nlm.nih.gov

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Reposted by Maria Gubbiotti, MD,PhD

Matt Campbell @mjcampbell.bsky.social · Jan 26

Palpably unfair act is definitely entering the lexicon #eagles

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 21

Grateful to work with such a fantastic group to learn new things and help our patients the best we can! #pathsky #medsky

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 19

Just like Texas rarely sees snow ❄️, every once in a while you will find a primary tumor of the posterior pituitary so keep it in mind during frozen section analysis! Here is a classic example of pituicytoma showing diffuse nuclear positivity for TTF1 #pathsky #neuropath #medsky 🔬 🧠

Smear preparation showing a fibrillary spindle cell neoplasm

Close up of the prior smear showing fibrillary to feathery cytoplasm and ovoid nuclei

H&E stained permanent section showing a whorled to spindled bland appearing tumor

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Reposted by Maria Gubbiotti, MD,PhD

AndrewFolpe @folpe-mn-st.bsky.social · Jan 8

#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 8

Nice!

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 3

😂 thanks! The upside to living in Texas is you get a beautiful mild winter after a brutally hot summer

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 2

Although this comment prompted me to go down a rabbit (er lizard?) hole and I found this paper about an endolymphatic sac neoplasm in a gecko

meridian.allenpress.com/jhms/article...

Endolymphatic Sac Carcinoma In Situ in a Tokay Gecko (Gekko gecko)

Abstract. An 11-year-old female tokay gecko (Gekko gecko) was presented for bilateral asymmetric swellings of the cervical region. Baseline hematologic and plasma biochemical analyses demonstrated ane...

meridian.allenpress.com

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 2

The pathology case is human, the equine pictured is just for fun

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Jan 2

Jumping into 2025 with an endolymphatic sac tumor, a VHL-associated neoplasm arising in the posterior petrous bone of the ear #pathsky #eqbsky #neuropath #entpath

H&E stained section of a papillary neoplasm with bland cells arising within the ear

Higher power view of a papillary neoplasm stained with H&E

A bay horse jumping an oxer in a grass field with a blue sky overhead

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Dec 24

Aired our grievances yesterday for Festivus and now enjoying the magic of Christmas Eve 🎄🎁🦄 #eqbsky

A bay horse and a person wearing a Buc-ee shirt with a blue sky in the background

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Dec 20

Asteroid hyalosis is an aging-associated condition of the eye where calcium and phospholipids build up giving the eye a grossly “glittery star-like” appearance (hence the name). Here is a vitreous cytology specimen before and after polarization showing the material 💫 👁️ #pathsky #medsky

A cytology preparation showing pink amorphous blobs

$Same specimen after polarization highlighting the refractory nature of the material$

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · Dec 18

Ours just turned 3 but went through a phase claiming a giant was in her room and so we have taken to “shooing the giant” so maybe you can shoo monsters too 😂 kids are so creative and weird but alas the solutions are usually equally creative and weird

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