Lightnews — Scholar-powered news

Marta Filizola @martafilizola.bsky.social · Aug 6

For your summer reading, check out the latest from our lab: www.biorxiv.org/content/10.1...

BOLD-GPCRs: A Transformer-Powered App for Predicting Ligand Bioactivity and Mutational Effects Across Class A GPCRs

G protein-coupled receptors (GPCRs) are important targets for drug discovery owing to their ability to respond to a broad range of stimuli and their involvement in numerous pathologies. Although tradi...

www.biorxiv.org

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Marta Filizola @martafilizola.bsky.social · Jun 25

Join an ever-inquisitive community of scholars who make strategic and meaningful connections between science, medicine, education, and health care delivery. We look forward to welcoming new Master’s classes in Biomedical Sciences and Data Science and AI youtu.be/NPNm4KOfwco

Graduate School of Biomedical Sciences – Master’s Programs

YouTube video by Icahn School of Medicine

youtu.be

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Reposted by Marta Filizola

Pernilla Wittung-Stafshede @professorpernilla.bsky.social · Jun 1

It’s time to vote! If you give me your vote, I promise I will work hard and loud for you, the BPS community, and for science. Read my statement.

www.biophysics.org/elections/bp...

BPS Elections | Biophysical Society

www.biophysics.org

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Reposted by Marta Filizola

Mario Barbatti @mbarbatti.bsky.social · May 31

Twenty case studies showing theoretical predictions in chemistry that were later confirmed experimentally. #CompChem 🧪

doi.org/10.1515/pac-...

When theory came first: a review of theoretical chemical predictions ahead of experiments

For decades, computational theoretical chemistry has provided critical insights into molecular behavior, often anticipating experimental discoveries. This review surveys twenty notable examples from t...

doi.org

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Reposted by Marta Filizola

Mike Galsworthy @mikegalsworthy.bsky.social · May 28

The US will not only suffer a brain drain… but will also lose its background brain gain from the rest of the world.

econ.trib.al/3hYAuUZ

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Reposted by Marta Filizola

Miriam Merad @miriammerad.bsky.social · May 26

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

“America First” Will Destroy U.S. Science

The U.S. government has sought to restrict immigration under the “America First” doctrine. These policies severely harm American science by stripping it of talent and eliminating a major driver of its...

www.cell.com

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Reposted by Marta Filizola

Jeremy Berg @jeremymberg.bsky.social · May 7

New Notice on No Cost Extensions (or lack thereof)

grants.nih.gov/grants/guide...

NOT-OD-25-110: Updated NIH Processes for No-Cost Extensions

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated NIH Processes for No-Cost Extensions NOT-OD-25-110. NIH

grants.nih.gov

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Reposted by Marta Filizola

Dan Minor @electrosomeucsf.bsky.social · Apr 24

New insights from our group into how frogs resist toxic environments published today! 🎉🐸
Congratulations to Sandra, Samantha @samnscience.bsky.social, Zhou, and our collaborators Tod Leighfield, Filizola lab @martafilizola.bsky.social, and Du Bois lab at Stanford.
www.nature.com/articles/s41...

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins

Nature Communications - Dinoflagellates and cyanobacteria produce saxitoxin (STX) congeners that block voltage-gated sodium channels. Here authors show how amphibians may sequester STX congeners...

www.nature.com

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Reposted by Marta Filizola

Ardem Patapoutian @ardemp.bskyverified.social · Apr 9

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

www.cnn.com

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Marta Filizola @martafilizola.bsky.social · Apr 8

Filizola lab - Gmeiner lab finally revealed onlinelibrary.wiley.com/doi/abs/10.1...

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

The β2-adrenergic receptor (β2AR) is a critical target for the treatment of airway diseases such as asthma or chronic obstructive pulmonary disease (COPD). To better understand its mechanism of actio...

onlinelibrary.wiley.com

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Reposted by Marta Filizola

Sara Reardon @sarareardon.bsky.social · Apr 2

"It’s kind of a textbook case of arbitrary and capricious.” A lawsuit alleges that NIH didn't follow proper procedure and was unconstitutionally vague when abruptly terminating >600 grants. My story @science.org www.science.org/content/arti...

Lawsuit aims to overturn many NIH grant terminations

Multiple groups and NIH-funded scientists challenge agency’s decision as arbitrary and capricious

www.science.org

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Marta Filizola @martafilizola.bsky.social · Apr 3

I sincerely hope that’s the case

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Marta Filizola @martafilizola.bsky.social · Apr 3

Carnage! www.thetransmitter.org/science-and-...

U.S. health agency purge includes 10 lab heads at National Institute of Neurological Disorders and Stroke

The reasons for selecting these researchers—who have led work on neuronal migration, dopamine receptors in neuronal signaling and the structure of ion channels, among other areas—remain unclear.

www.thetransmitter.org

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Marta Filizola @martafilizola.bsky.social · Mar 26

I am afraid you are correct, my friend 😥

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Marta Filizola @martafilizola.bsky.social · Mar 26

So sorry, Rommie. Disgraceful!

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Reposted by Marta Filizola

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 22

Why AI won’t replace scientists capable of making disruptive conceptual breakthroughs - they pose questions that challenge, rather than align with, the training data set

thomwolf.io/blog/scienti...

🔭 The Einstein AI model

I shared a controversial take the other day at an event and I decided to write it down in a longer format: I’m afraid AI won't give us a compressed 21st century.

thomwolf.io

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Marta Filizola @martafilizola.bsky.social · Mar 21

Are you aiming for leadership roles in pharmaceutical, biotech, high tech, or medical device companies? Consider applying to the revamped MSBS program @GradSchoolSinai @IcahnMountSinai, featuring 1 or 2-year tracks and non-thesis options tailored for industry professionals

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Marta Filizola @martafilizola.bsky.social · Mar 19

At @GradSchoolSinai @IcahnMountSinai, we are excited to train the next generation of #datascience and #AI #professionals for #PrecisionMedicine @MountSinaiNYC
and beyond. Apply here: icahn.mssm.edu/education/ad...

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Reposted by Marta Filizola

JoAnn Trejo @joann-trejo.bsky.social · Mar 16

You got 5 min to really understand the real costs of scientific research - check out this video

www.youtube.com/watch?v=GzNc...

Understanding the Real Costs of Research

YouTube video by AAMCtoday

www.youtube.com

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Marta Filizola @martafilizola.bsky.social · Mar 13

New picture for the Filizola lab on the relentless quest for breakthrough science to build a brighter future. Bring it on!

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Marta Filizola @martafilizola.bsky.social · Mar 8

FRESH OFF THE PRESS
@filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....

Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs

G protein-coupled receptors (GPCRs) remain a focal point of research due to their critical roles in cell signaling and their prominence as drug targets. However, directly linking drug efficacy to the ...

pubs.acs.org

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Reposted by Marta Filizola

Lucas C Parra @lcparra.bsky.social · Mar 7

Large crowd in New York City at Stand Up for Science.

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Marta Filizola @martafilizola.bsky.social · Mar 1

www.nature.com/articles/s41...

Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways - Nature Communications

GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug ...

www.nature.com

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Marta Filizola @martafilizola.bsky.social · Mar 1

Francis Collins Retires From N.I.H. www.nytimes.com/2025/03/01/u...

Francis Collins Retires From N.I.H., Saying Colleagues ‘Deserve the Utmost Respect’

Dr. Collins, a renowned geneticist, ran the National Institutes of Health for 12 years. His parting statement offered a pointed, if veiled, message to the Trump administration.

www.nytimes.com

Reposted by Marta Filizola

Eric Topol @erictopol.bsky.social · Mar 1

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

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