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Martin Smith @martinalexsmith.bsky.social · 1d

Adaptive sampling #WGS is moving from bench to bedside. Our work delivers SNV, structural & methylation insights on @nanoporetech.com with molecular signals emerging in minutes, not days. Watch this space 👀 #cancer #genomicAI #MultiOmics #bioinformatics @cra-chusj.bsky.social
tinyurl.com/4d337djb

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Martin Smith @martinalexsmith.bsky.social · 10d

C.f.
asmr.org.au/wp-content/u...

asmr.org.au

Martin Smith @martinalexsmith.bsky.social · 10d

If we doubled the allocation of MRFF grants, the fund would break even after 10 years BUT there would be twice as many economic returns from biomedical research innovations, boosting GDP and Australia's highly skilled workforce.
As a reminder, the estimated long term ROI for MRFF grants is $4:$1

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Martin Smith @martinalexsmith.bsky.social · 10d

Given how stingy public research funding is overall, it's shocking that the #MRFF only spends 50% of what is allocated in the budget.
This funds highly impactful, translational research focused fund that can DIRECTLY address the economic burdens of the healthcare system + improved patient outcomes

Prof Gina Ravenscroft🇿🇦🇦🇺 @ginaravenscroft.bsky.social · 10d

The National Association of Research Fellows join the call for full disbursement of the #MRFF #DiscoveriesNeedDollars
www.theage.com.au/politics/fed...

Billions going unspent from Australia’s $24b medical research fund

Costings commissioned by independent MP Monique Ryan reveal the government could double how much funding it gives to innovative health research each year.

www.theage.com.au

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Martin Smith @martinalexsmith.bsky.social · 16d

28km, 7 bridges, 2 family members raising funds for #CancerCouncil
In honour of their grandparents.

If you can spare a gold coin, please help support my wife and son for a second year in a row 🎗️

www.7bridgeswalk.com.au/fundraisers/...

#fuckCancer #cancer #research

nicole: walking for a cancer free future

I’m taking on 7 Bridges Walk to help those affected by cancer. Please donate to my page. Every step counts because all funds raised will help Cancer Council work towards the vision of a cancer free fu...

www.7bridgeswalk.com.au

Martin Smith @martinalexsmith.bsky.social · 19d

Genomics is the future of cancer treatment.
The PAGES project is making sure Aboriginal Australians are part of that future.

🎬 Watch now 👉 www.youtube.com/watch?v=dRfX...

#precisionMedicine #healthEquity #genomics #firstNations

The PAGES Study

YouTube video by Co-Design Health Research & Innovation

www.youtube.com

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Martin Smith @martinalexsmith.bsky.social · 25d

Asking someone how they define a gene leads to really insightful answers (at least when they respond with something beyond a protein coding sequence), but there clearly is room for refinement.

A "unit of hereditary function" is my broad definition, with 'unit' and 'function' open to interpretation

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Martin Smith @martinalexsmith.bsky.social · 25d

So you would define a gene by its promoter and coding sequence?
What about overlapping isoforms with partial protein sequence and different promoter/TSS?
Conversely, what about a segmental duplication/paralog with identical RNA coding sequence but different promoters?

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Martin Smith @martinalexsmith.bsky.social · 25d

Another case for distinct genes: polycistrons in bacteria, kinetoplastidae, and mitochondria

Martin Smith @martinalexsmith.bsky.social · 25d

Analogously, is a microRNA considered a different gene to it's pre-miRNA?
A case for the affirmative: snoRNAs are clearly annotated as distinct genes form their host transcripts, which are (often) intronic regions of mRNAs

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Martin Smith @martinalexsmith.bsky.social · 25d

For example: pmc.ncbi.nlm.nih.gov/articles/PMC...

Expression of distinct RNAs from 3′ untranslated regions

The 3′ untranslated regions (3′UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3′UTRs in human, mouse and fly are also ...

pmc.ncbi.nlm.nih.gov

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Martin Smith @martinalexsmith.bsky.social · 25d

Existential #RNAsky question for the weekend:
If two RNA products share the same promoter/TSS, but have different 5' ends (one is processed out of longer transcript) and are differentially expressed, are they different isoforms or distinct genes?

a man with a white wig and beard is standing in front of trees

ALT: a man with a white wig and beard is standing in front of trees

media.tenor.com

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Martin Smith @martinalexsmith.bsky.social · 28d

LLM chat bot generated requests for HDR supervision are so generic and obvious, it makes sifting through applications that much easier.
I'm concerned for new tenure track academics -- I hope they can sniff out these copy paste requests, maybe by using honeypots on university research profiles?

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Martin Smith @martinalexsmith.bsky.social · Sep 5

Don't miss @osvaldoics.bsky.social in the flesh next Tuesday in Sydney

Martin Smith @martinalexsmith.bsky.social · Sep 5

Some exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬

9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3

15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 [email protected]

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Martin Smith @martinalexsmith.bsky.social · Sep 5

Some exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬

9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3

15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm
📩 [email protected]

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Martin Smith @martinalexsmith.bsky.social · Sep 4

Congratulations to @hasindu2008.bsky.social form #UNSW Computer Science and Engineering for wearing a tuxedo last night 👏🏻
Also for being awarded the #EurekaPrize for outstanding early career researcher, showcase his pioneering and impacftful research in #bioinformatics software

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Martin Smith @martinalexsmith.bsky.social · Sep 3

Register here ⤵️
collections.humanitix.com/sydney-biomo...

Sydney Biomolecular Condensates Symposium 2025 | Humanitix

Join us in Sydney for a two-day discussion, discovery, and connection around biomolecular condensates. This symposium is organized by both The University of Sydney (USYD) and The University of New Sou...

collections.humanitix.com

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Martin Smith @martinalexsmith.bsky.social · Sep 3

Prof Cecile King finishing her #ARNASydney2025 talk on biomolecular condensates by promoting the upcoming (free) symposium on the topic in November

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Martin Smith @martinalexsmith.bsky.social · Sep 2

Agta2025.org
Not .com

Agta2025.org

Martin Smith @martinalexsmith.bsky.social · Sep 2

@thermofishersci.bsky.social
@decodescience.bsky.social
@garvaninstitute.bsky.social @ramacgenomics.bsky.social
@nanoporetech.com
@agrf.bsky.social
@revvity.bsky.social
Apologies if I missed some sponsor or exhibitor accounts (please let me know if so) #AGTA2025

Martin Smith @martinalexsmith.bsky.social · Sep 2

Early bird deadline extended for #AGTA #AGTA2025
This year will be quite different, with a big focus on tech, low cost Rego, digital engagement, and in a central location.
Don't miss the ECR events, exhibitor lounges (à la AGBT) and two lightning talk sessions, open to industry members: agta2025.com

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Martin Smith @martinalexsmith.bsky.social · Sep 2

Early bird deadline extended for #AGTA #AGTA2025
This year will be quite different, with a big focus on tech, low cost Rego, digital engagement, and in a central location.
Don't miss the ECR events, exhibitor lounges (à la AGBT) and two lightning talk sessions, open to industry members: agta2025.com

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Reposted by Martin Smith

Selene FeRNAndez @selfdz.bsky.social · Sep 2

Yesterday we had a brilliant start to #ARNASydney2025. We kicked off with the #RNA in neuroscience & RNA tech, AI & Bioinformatics sessions. Speakers included @sergiuppasca.bsky.social, Mike Clark, @sabaaltaf.bsky.social, Nicole Green and several others

#RNASky @unswrna.bsky.social

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Martin Smith @martinalexsmith.bsky.social · Sep 2

Prof Nils Walter from U.Michigan back in Sydney, mentions it's his favourite place!
Opening up the #ARNASydney2025 structure, chemistry and dynamics session.

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Reposted by Martin Smith

Timothy Bredy @twbredy.bsky.social · Sep 1

#A-RNA2025 off to a great start. @martinalexsmith.bsky.social sharing his views on why lncRNAs should no longer be consider wallflowers.

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Martin Smith @martinalexsmith.bsky.social · Sep 1

The annual meeting of the Australasian RNA association is on for the next 3 days at UTS.
Possibly one of the longest hashtags ever #ARNASydney2025

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