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Timothy Bredy @twbredy.bsky.social · 17h

Say what? 👍

Ryan Flynn @raflynn5.bsky.social · 1d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

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Timothy Bredy @twbredy.bsky.social · 19h

Like!

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

A good day to remember John Gurdon’s school report from his biology master at Eton

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Timothy Bredy @twbredy.bsky.social · 23h

TNTs for the win! RNA transfer is a thing.

www.science.org/doi/10.1126/...

Intercellular communication in the brain through a dendritic nanotubular network

Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

www.science.org

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Timothy Bredy @twbredy.bsky.social · 1d

Solid thread.

Sophia Davidson @sciencesophie.bsky.social · 1d

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...

So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!

#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience

@nhmrc.bsky.social

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Timothy Bredy @twbredy.bsky.social · 2d

RNA in neuroscience people, save the date, this course is going to be epic. All are welcome!

www.neurosas.org/advanced-cou...

RNA Technologies and Therapeutics for Neuroscience - Neuroscience School of Advanced Studies

RNA Technologies and Therapeutics for Neuroscience May 30-June 7, 2026 Director: Timothy Bredy University of Queensland, Australia Faculty: Gene Yeo, University of California, San Diego, USA Eri...

www.neurosas.org

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Timothy Bredy @twbredy.bsky.social · 2d

Nowadays, too many institutions thinking ‘if we build it they will come’ combined with a shortsighted research funding model, a saturated Phd training sector, bloated admin load, and a general decline in creativity. Tough times indeed!

Kevin J. CREATURE @kevinjkircher.com · 4d

Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.

sites.stat.columbia.edu

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Timothy Bredy @twbredy.bsky.social · 8d

Occasional PSA:

Intracellular molecular processing, especially in neurons, is not about differential RNA expression or even protein abundance for that matter. Not about quantity.

It’s about qualitative, functional states.

The sooner we get there as a community the faster the science advances

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Timothy Bredy @twbredy.bsky.social · 8d

RNA and Proteins: Who Bosses Whom? | Science | AAAS www.science.org/content/blog...

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Timothy Bredy @twbredy.bsky.social · 12d

Look at the other two, also interesting!

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Timothy Bredy @twbredy.bsky.social · 12d

bsky.app/profile/twbr...

Timothy Bredy @twbredy.bsky.social · 16d

We've been busy in the lab, and I'm super proud of the team right now. These three papers are great examples of "Night Science", creative, curiosity driven work at its best! All are works in progress.

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

Vaults are large ribonucleoprotein complexes of unknown function in neurons. Here, we report that the Vault-associated noncoding RNA, Vaultrc5, is highly enriched at the synapse and is required for ac...

www.biorxiv.org

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Timothy Bredy @twbredy.bsky.social · 16d

We've been busy in the lab, and I'm super proud of the team right now. These three papers are great examples of "Night Science", creative, curiosity driven work at its best! All are works in progress.

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

Vaults are large ribonucleoprotein complexes of unknown function in neurons. Here, we report that the Vault-associated noncoding RNA, Vaultrc5, is highly enriched at the synapse and is required for ac...

www.biorxiv.org

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Timothy Bredy @twbredy.bsky.social · 18d

This was huge effort that involved many great friends and colleagues, including Sourav Banerjee, Howard Chang, C.K. Chen, Xiang Li, Wei Wei, @irinavoineagu.bsky.social, @anggonolab.bsky.social, and the entire lab @QueenslandBrainInstute.

Timothy Bredy @twbredy.bsky.social · 18d

How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain.

www.biorxiv.org/cgi/content/...

Local translation of circular RNAs is required for synaptic activity and memory

Circular RNAs (circRNAs) are enriched in synapses and implicated in cognitive processes, and recent studies have shown that circRNAs can encode micropeptides, which suggests that there may be novel sy...

www.biorxiv.org

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Timothy Bredy @twbredy.bsky.social · 18d

How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain.

www.biorxiv.org/cgi/content/...

Local translation of circular RNAs is required for synaptic activity and memory

Circular RNAs (circRNAs) are enriched in synapses and implicated in cognitive processes, and recent studies have shown that circRNAs can encode micropeptides, which suggests that there may be novel sy...

www.biorxiv.org

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Timothy Bredy @twbredy.bsky.social · 18d

First of two major paper drops this week. Ever hear of extrachromosomal DNA?

Mostly studied in the context of cancer and oncogene amplification, we’ve found an important role for these peculiar DNA elements in the brain! #neuroepigenetics #memory

www.biorxiv.org/cgi/content/...

A mobile circular DNA element drives memory-related processes in mice

Extrachromosomal circular DNAs (ecDNAs) are double stranded, closed loop DNA molecules that act independently of the genome. Here we report the discovery of a brain-enriched ecDNA, ecCldn34d, that reg...

www.biorxiv.org

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Reposted by Timothy Bredy

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 20d

Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation https://www.biorxiv.org/content/10.1101/2025.09.15.676326v1

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Timothy Bredy @twbredy.bsky.social · 20d

Happy days with images like this….

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Timothy Bredy @twbredy.bsky.social · 21d

kops.uni-konstanz.de/server/api/c...

kops.uni-konstanz.de

Timothy Bredy @twbredy.bsky.social · 21d

If it holds up in vivo, could take brain science to a whole other level.

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Timothy Bredy @twbredy.bsky.social · 21d

pubmed.ncbi.nlm.nih.gov/35107112/

Single-molecule conductance of double-stranded RNA oligonucleotides - PubMed

RNA oligonucleotides are crucial for a range of biological functions and in many biotechnological applications. Herein, we measured, for the first time, the conductance of individual double-stranded (...

pubmed.ncbi.nlm.nih.gov

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Timothy Bredy @twbredy.bsky.social · 22d

RNA can conduct electricity. Isn’t that interesting?

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