Lightnews — Scholar-powered news

Martin Sauvageau @martinsauvageau.bsky.social · 12d

Congrats Jen

Reposted by Martin Sauvageau

Nicky Whiffin @nickywhiffin.bsky.social · Sep 8

While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior.

These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy

🧵 by the amazing @christeldepienne.bsky.social 👇

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Christel Depienne @christeldepienne.bsky.social · Sep 5

After our study on RNU4-2 and RNU5B-1 published in May (Nava et al, Nature Genetics 2025), I am excited to share our new preprint reporting dominant and recessive variants in RNU2-2 as a frequent cause of developmental and epileptic encephalopathy (DEE).

📄 www.medrxiv.org/content/10.1...

Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies

Variants in spliceosomal small nuclear RNA (snRNA) genes RNU4-2 (ReNU syndrome), RNU5B-1 , and RNU2-2 have recently been linked to dominant neurodevelopmental disorders (NDDs), revealing a major, prev...

www.medrxiv.org

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Reposted by Martin Sauvageau

Institut de recherches cliniques de Montréal (IRCM) @ircm.bsky.social · Aug 21

Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health.
🔗 bit.ly/3HGWhX3

🎉 Congratulations to Dr. Jean-François Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research—particularly on cell migration and metastasis—as well as his commitment to collaboration and innovation in health.
A well-deserved recognition! 👏

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Martin Sauvageau @martinsauvageau.bsky.social · Aug 25

Proud to see this work on a new #machinelearning model, ECSFinder, now online academic.oup.com/nar/article/...

This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick.

Full thread 👇🏼

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Reposted by Martin Sauvageau

Danny IncaRNAto @incarnatolab.bsky.social · Jul 27

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis - Nature Biotechnology

Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.

nature.com

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Reposted by Martin Sauvageau

Mitch Guttman @mitchguttman.bsky.social · Jul 26

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

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Reposted by Martin Sauvageau

Mike Fainzilber @mfainzilber.bsky.social · May 16

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Repeat-element RNAs integrate a neuronal growth circuit

SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

www.cell.com

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Reposted by Martin Sauvageau

D2R | DNA to RNA @d2rmcgill.bsky.social · Jun 21

🚨 @healthsciences.mcgill.ca‬ is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics

Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.

✍ Apply by July 4:

Canada Excellence Research Chair (CERC) in RNA Neurotherapeutics

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at…

buff.ly

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Reposted by Martin Sauvageau

Igor Ulitsky @igorulitsky.bsky.social · May 29

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression

Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...

biorxiv.org

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Martin Sauvageau @martinsauvageau.bsky.social · May 30

Congrats Igor and team. Very nice work. Chaserr is such a beautiful example of how lncRNAs can be important in disease and could potentially be targeted for therapeutic purposes.

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Reposted by Martin Sauvageau

Dr. Julie Claycomb @farmgirlphd.bsky.social · May 23

Hello out there! Are you looking for a friendly community to share your RNA research and hear about some cool RNA biology? Register for @trendrna.bsky.social on July 10-11 now! Oral abstract deadline is May 30th! Co sponsored by @rnacanada.bsky.social!

TREnD @trendrna.bsky.social · May 18

We are excited to announce that registration for this year's Toronto RNA Enthusiasts' Day (TREnD) is now open!

July 10th, 1pm-4pm ET ONLINE for everyone

July 11th, 9am-7pm ET ONLINE across Canada and IN PERSON in Toronto

event.fourwaves.com/trend25/regi...

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Martin Sauvageau @martinsauvageau.bsky.social · May 20

The IRCM #RNATherapeutics Core Facility is also part the AReNA's Network for the Development & Production of RNA Therapeutics of Quebec (DePTAQ) together with @mcgill-research.bsky.social @d2rmcgill.bsky.social and @usherbrooke.bsky.social

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Martin Sauvageau @martinsauvageau.bsky.social · May 20

You will play a central role in the core facility services and in the development of different modalities of #RNA therapeutics (#ASO, #siRNA, #mRNA-LNP). This position offers a unique opportunity to contribute to cutting-edge research and be part of the vibrant Montreal RNA community.

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Martin Sauvageau @martinsauvageau.bsky.social · May 20

We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal.

More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...

Research Assistant - RNA Therapeutics Core Facility

www.ircm.qc.ca

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Reposted by Martin Sauvageau

Mike Fainzilber @mfainzilber.bsky.social · May 16

A 🧵 to walk those interested through this paper...

Mike Fainzilber @mfainzilber.bsky.social · May 16

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Repeat-element RNAs integrate a neuronal growth circuit

SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

www.cell.com

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Reposted by Martin Sauvageau

Kurianlab @kurianlab.bsky.social · May 17

www.science.org/doi/10.1126/...

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...

www.science.org

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Reposted by Martin Sauvageau

NPR @npr.org · May 15

For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.

A promising genetic treatment tailor-made for a baby born with a rare disorder

For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.

www.npr.org

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Reposted by Martin Sauvageau

RNA Canada @rnacanada.bsky.social · May 14

Next week! RNA Canada sponsored series:
Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...

Poster for RNA Canada ARN Education Series

Perspectives on RNA: RNA Chemistry and its applications

Wednesday, May 21st, 3-4:30 pm EST / 12-1:30 pm PST

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Reposted by Martin Sauvageau

Karim Majzoub @karimaj.bsky.social · Apr 7

Beautiful paper

Exogenous RNA surveillance by proton-sensing TRIM25

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

www.science.org

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Reposted by Martin Sauvageau

Josh Mendell @mendell-lab.bsky.social · Apr 3

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation

Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

www.cell.com

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Martin Sauvageau @martinsauvageau.bsky.social · Apr 4

Very interesting study and neat mechanism. Congrats Josh and team.

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Reposted by Martin Sauvageau

D2R | DNA to RNA @d2rmcgill.bsky.social · Apr 3

🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN

Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !

📅5 mai 2025 🕐12h45

💡 En savoir plus : mcgill.ca/dna-to-rna/f...

#ACFAS8

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Reposted by Martin Sauvageau

D2R | DNA to RNA @d2rmcgill.bsky.social · Apr 3

🚨 Appel à proposition 🚨

D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN !

$350 000 pour 2 ans
Date limite : 15 mai 2025

🔗https://buff.ly/Ub5D45x

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Martin Sauvageau @martinsauvageau.bsky.social · Apr 2

If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details.
www.nature.com/naturecareer...

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461

Canada Excellence Research Chairs (CERC)

www.nature.com

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Reposted by Martin Sauvageau

Mathieu Ferron @mathieuferron.bsky.social · Apr 2

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years.

Contact me if you are interested.

www.nature.com/naturecareer...

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461

Canada Excellence Research Chairs (CERC)

www.nature.com

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