marvintanenbaum.bsky.social
Marvin Tanenbaum
@marvintanenbaum.bsky.social
630 followers 180 following 22 posts
Visualizing RNA regulation in living cells, one molecule at a time. Human and viral RNAs. Hubrecht Institute, Oncode Institute and dept. of Bionanoscience, TU Delft
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 3
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation

www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
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Reposted by Marvin Tanenbaum
esthernoltethoen.bsky.social
esthernoltethoen.bsky.social @esthernoltethoen.bsky.social · Aug 2
Curious about where, how and when #extracellularvesicles fuse with target cells?

A new methodology developed in our group, spearheaded by Jasper van den Ende, provides insight in this process.

EV-FUSIM: an EV-Fusion Spatiotemporal Imaging Method.
www.biorxiv.org/content/10.1...
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jul 15
The Hubrecht Institute has an open call for it's PhD program. It's a great place to work and do research, so apply!
hubrechtinstitute.bsky.social
Hubrecht Institute @hubrechtinstitute.bsky.social · Jul 10
🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jul 8
Wow, very interesting!
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jul 7
viruses?
marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jul 4
Really nice paper on a new sensor for double-stranded RNA:

Prkra dimer senses double-stranded RNAs to dictate global translation efficiency: Molecular Cell www.cell.com/molecular-ce...
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency
Prkra serves as a primary dsRNA sensor in pluripotent cells, restricting RNA virus replication. By dimerizing through dsRBD3, it sequesters eIF2 complexes from the translation machinery and compensate...
www.cell.com
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jun 26
Can anyone recommend good mRNA therapeutics conferences that are coming up? Ideally conferences that are attended by both industrial and academic researchers?
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Reposted by Marvin Tanenbaum
hubrechtinstitute.bsky.social
Hubrecht Institute @hubrechtinstitute.bsky.social · Apr 28
It's possible to apply for the Hubrecht Talent Program again!
The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research.

Read more in the flyer and on www.hubrecht.eu/about-us/hub...
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Apr 15
Very honored to receive the Ammodo Science Award for fundamental research! Great recognition for the amazing work done by all our group members, both past and present, over the past 10 years! Also a huge congrats to my co-awardee Leila Akkari!

www.ammodo-science.org/researches/m...
Marvin Tanenbaum
Marvin Tanenbaum is developing revolutionary imaging techniques that allow him to film molecular processes in living cells at the level of individual biomolecules.This provides fundamentally new insig...
www.ammodo-science.org
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Mar 28
Sounds really exciting!
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Mar 28
Amazing work led by Dhanushika Ratnayake, and a huge thanks to the large group of fantastic collaborators!
marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Mar 28
Very excited to share a new paper from the lab! We visualize RSV infection with single-vRNP resolution and show how the virus coordinates transcription and replication with the formation of viral factories, biomolecular condensates that act as sites of viral genome control.

doi.org/10.1101/2025...
Pre-assembly of biomolecular condensate seeds drives RSV replication
During infection many RNA viruses, including respiratory syncytial virus (RSV), form specialized biomolecular condensates, inclusion bodies (IBs), where viral transcription and replication occur[1][1]...
doi.org
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Reposted by Marvin Tanenbaum
jmtali.bsky.social
Matthew Taliaferro @jmtali.bsky.social · Feb 28
Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 28
Check out the latest paper from our collaboration with the Kuppeveld lab where we use a combination of virology and single-molecule imaging assays to reveal the role of the enterovirus 2A protein:
www.biorxiv.org/content/10.1...
The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses
Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Apro and 3Cpro have been implicated in these processes base...
www.biorxiv.org
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 28
Super happy to receive a VICI grant from NWO! 5 more years of studying mRNA translation using single-molecule imaging
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 18
This is also our experience. Photobleaching of FPs is often reported at low excitation power (e.g. LED based widefield), and it is often unpredictable how such FPs will behave at high power, for example when using a different microscope modality
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Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 12
Wow, very nice!
tim-stasevich.bsky.social
@tim_stasevich @tim-stasevich.bsky.social · Feb 12
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 3
Amazing work lead by @maxmadern.bsky.social and Sora Yang, and a very nice collaboration with @mariannebauer.bsky.social and Olivier Witteveen. @hubrechtinstitute.bsky.social
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Feb 3
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation

www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
4 46 110
marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jan 30
Wow, mindblowing!
nature.com
Nature @nature.com · Jan 29
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise

https://go.nature.com/4hDtGhL
Asteroid fragments upend theory of how life on Earth bloomed
Samples from Bennu contain the chemical building blocks of life - but with a twist.
go.nature.com
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Reposted by Marvin Tanenbaum
michamuller.bsky.social
Micha Müller @michamuller.bsky.social · Jan 21
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jan 21
Janin Schokolowski now on bluesky too: @janinschoko.bsky.social
janinschoko.bsky.social
PhD student in the Tanenbaum Lab at the Hubrecht Institute, long-term fan of live-cell imaging, now infected by Influenza A research
janinschoko.bsky.social
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Marvin Tanenbaum @marvintanenbaum.bsky.social · Jan 21
Fantastic, multidisciplinary team effort by Huib Rabouw, Janin Schokolowski and @michamuller.bsky.social with enormous help from @baarsmatthijs.bsky.social and Jakob Puschel and great collaborations with @hansclevers.bsky.social's and Ron Fouchier's groups!
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jan 21
Our new paper is out: "Mapping the complete influenza A virus infection cycle through single vRNP imaging". Combining newly-developed single-molecule imaging approaches with in situ viral transcriptomics, we identify numerous non-canonical infection pathways.

www.biorxiv.org/content/10.1...
Mapping the complete influenza A virus infection cycle through single vRNP imaging
Cell-to-cell heterogeneity is a common feature of viral infection that can generate enormous complexity, complicating understanding of infection progression and interpretation of differences between v...
www.biorxiv.org
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Jan 17
I love this paper!
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marvintanenbaum.bsky.social
Marvin Tanenbaum @marvintanenbaum.bsky.social · Dec 12
This is really interesting. Have other people observed NGD outside of yeast? We haven't seen much evidence of mRNA decay caused by ribosome stalling or collisions in human cells
roliroberts.bsky.social
Roli Roberts @roliroberts.bsky.social · Dec 9
Has no-go decay (NGD), like NMD, become co-opted by organisms to regulate endogenous mRNAs? A study in @plosbiology.bsky.social shows that during zebrafish development, mRNAs encoding C2H2-ZF domains cause ribosome stalling and trigger NGD. plos.io/4g4RESq
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