Jason McLellan
@mclellanlab.bsky.social
Structural virology / Structure-based vaccine design
mclellanlab.org
Professor of Molecular Biosciences
The University of Texas at Austin
Opinions are my own and not the views of my employer
mclellanlab.org
Professor of Molecular Biosciences
The University of Texas at Austin
Opinions are my own and not the views of my employer
Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
January 27, 2026 at 8:53 PM
Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
New Year's Eve Red Wings game with the family!
January 1, 2026 at 1:31 AM
New Year's Eve Red Wings game with the family!
Completed with 100% yesterday. Gearing up for some speed runs now.
November 1, 2025 at 12:27 AM
Completed with 100% yesterday. Gearing up for some speed runs now.
Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months
October 31, 2025 at 10:31 PM
Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
August 19, 2025 at 6:24 PM
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
June 18, 2025 at 2:24 PM
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
May 20, 2025 at 6:19 PM
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
Getting ready for the Viruses and Cells GRC in Castelldefels
May 18, 2025 at 12:46 PM
Getting ready for the Viruses and Cells GRC in Castelldefels
New exhibit at the National Inventors Hall of Fame 👀
May 7, 2025 at 5:56 PM
New exhibit at the National Inventors Hall of Fame 👀
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
March 25, 2025 at 3:18 PM
We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.
Taking the family to their first Red Wings game!
December 29, 2024 at 9:33 PM
Taking the family to their first Red Wings game!
Register now to hear some cool vaccine science! I'll be speaking at this conference, so come hang out!
December 6, 2024 at 5:45 PM
Register now to hear some cool vaccine science! I'll be speaking at this conference, so come hang out!
Time for a name change?
November 30, 2024 at 7:16 AM
Time for a name change?
Let's go Lions!
November 28, 2024 at 6:37 PM
Let's go Lions!
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
November 13, 2024 at 6:28 PM
My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝
ACL Music Festival! Teddy Swims on stage.
November 24, 2024 at 2:49 AM
ACL Music Festival! Teddy Swims on stage.
View from Austin, TX
November 24, 2024 at 2:49 AM
View from Austin, TX
Saw Road House with the cast at SXSW!
November 24, 2024 at 2:49 AM
Saw Road House with the cast at SXSW!
Promising results for a third PreF-based RSV vaccine: https://www.nejm.org/doi/10.1056/NEJMoa2307079
November 24, 2024 at 2:49 AM
Promising results for a third PreF-based RSV vaccine: https://www.nejm.org/doi/10.1056/NEJMoa2307079
My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286
October 2, 2023 at 5:48 PM
My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286
My babies are the October Molecule of the Month https://pdb101.rcsb.org/motm/286
November 24, 2024 at 2:57 AM
My babies are the October Molecule of the Month https://pdb101.rcsb.org/motm/286
Had a blast at the @blink182 concert last night at @MoodyCenterATX!
November 24, 2024 at 3:04 AM
Had a blast at the @blink182 concert last night at @MoodyCenterATX!
Arrived in Montreux, ready for @nidovirus2023!
November 24, 2024 at 3:04 AM
Arrived in Montreux, ready for @nidovirus2023!