Lightnews — Scholar-powered news

Meredith Braskie @meredithbraskie.bsky.social · 2d

🚨New paper alert!
Looks at how amyloid, tau, & neurodegeneration vary by ethnoracial group & sex in Hispanic & non-Hispanic Black & White adults from HABS-HD.
Led by Dr. Michelle Caunca in Dr. Kristine Yaffe's lab.
Read here ➡️ bit.ly/4gUbwJi
@uscloni.bsky.social

Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS‐HD cohort

INTRODUCTION Racial/ethnic and sex/gender differences in neuroimaging markers of dementia have been previously explored, but rarely with an intersectional approach. METHODS Using data from the Hea.....

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Meredith Braskie @meredithbraskie.bsky.social · 8d

🚨New Paper Alert:
🔎Progression to MCI & dementia in 3 cohorts:
🧠Tau PET+ ➡️ faster cog decline.
🧠 50% of MCI patients ➡️ dementia in 2.36 years if amyloid+ & high tau at baseline.
Led by Lydia Trudel & Joseph Therriault
Dr. Pedro Rosa-Neto's lab
Read ➡️ bit.ly/46x3Byd

Rates of clinical progression according to biological Alzheimer's disease stages

INTRODUCTION Predicting the rate of cognitive decline and the likelihood of progression to dementia remains a critical unmet need in clinical settings. METHODS We assessed progression to mild cogn...

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Meredith Braskie @meredithbraskie.bsky.social · 27d

Great update on progress in neuroimaging of Alzheimer's disease!

Julie Ottoy @ottoyjulie.bsky.social · 29d

🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨

dx.doi.org/10.1002/alz....

➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?

@istaart.bsky.social Neuroimaging PIA

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Reposted by Meredith Braskie

USC INI @uscini.bsky.social · Aug 27

We’re excited to welcome our newest Trojans into our Master of Science program at USC!
This year they’ll:
Train on state-of-the-art MRI
Explore computational modeling & big data
Collaborate with world-class faculty
Build skills to launch careers in neuroscience, medicine & industry✌️🧠

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Meredith Braskie @meredithbraskie.bsky.social · Aug 27

Recent pictures from the Getty Museum gardens, otherwise known as "the good place".

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Meredith Braskie @meredithbraskie.bsky.social · Aug 18

🚨New paper alert!
Methods & insights from the Health & Aging Brain Study – Health Disparities (HABS-HD) 🧠📊
We examine amyloid, tau, neurodegeneration, cognition & social determinants of health in Hispanic & NH Black & White older adults.
➡️ bit.ly/4mwp67J
@uscini.bsky.social

Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics

INTRODUCTION The Health and Aging Brain Study–Health Disparities (HABS-HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of t.....

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Reposted by Meredith Braskie

Hussein N. Yassine @yassinelab1.bsky.social · Aug 15

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease-Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single....

onlinelibrary.wiley.com

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Meredith Braskie @meredithbraskie.bsky.social · Aug 1

The Jagust Lab alumni dinner is one of my favorite parts of AAIC each year - and this year was no exception. What an amazing group of people, brought together by an extraordinary mentor!

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Meredith Braskie @meredithbraskie.bsky.social · Jul 30

🚨Online #AAIC25 diabetes poster by Amaryllis Tsiknia!
Can a drink of glucose change functional brain connectivity?
🥮+🧠= 🔎
"Default mode network connectivity responses to glucose ingestion in cognitively unimpaired older adults with and without type 2 diabetes"
@uscini.bsky.social

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Meredith Braskie @meredithbraskie.bsky.social · Jul 29

🟣At #AAIC25? Come talk science with Zoe Tsokolas at poster 490 today.
🧠APOE-ɛ4 moderates the association between HDL-c and white matter hyperintensity volume.
⏲️ 3:30 - 4:15 pm
@uscini.bsky.social

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Meredith Braskie @meredithbraskie.bsky.social · Jul 29

🎤 Come see Koral Wheeler's talk today at #AAIC25, relating plasma markers of inflammation to longitudinal tau PET in Hispanic, non-Hispanic Black & non-Hispanic White non-demented older adults.
🧠 Session: Developing Topics on Tau Biomarkers
🕝 2:42–2:49 PM | 📍 Room 701
@uscini.bsky.social

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Meredith Braskie @meredithbraskie.bsky.social · Jul 28

I do, in fact, love this image. So cool!

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Meredith Braskie @meredithbraskie.bsky.social · Jul 27

At #AAIC25? Come check out Danielle Luu's poster, "Genetic Variants and Brain Tau Levels" today from 3:30-4:15 pm at poster 106. We related genetic variants to PI-2620 tau PET in Hispanic, non-Hispanic Black, and non-Hispanic White older adults 🧠🧬
@uscini.bsky.social

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Meredith Braskie @meredithbraskie.bsky.social · Jul 25

✈️Off to #AAIC25 in Toronto!
Excited to share our new research 🧠🧬
• Tau PET & genetic variants
• APOE, HDL, & WMH
• Longitudinal tau PET & inflammation
• DMN & glucose in aging & T2DM

See our full presentation lineup ⬇️
👋Come talk science with us!

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Reposted by Meredith Braskie

Suzanne E. Schindler @suzanneeschindler.bsky.social · Jul 14

"Clocks" that relate amyloid and tau PET to time were used to examine the timing of biomarker changes (including plasma biomarkers) in Alzheimer disease. Plasma Aβ42/40 changes very early! onlinelibrary.wiley.com/doi/10.1002/...

#ENDALZ

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

Objective The objective of this study was to evaluate the timing of change of Alzheimer's disease (AD) plasma biomarkers (Aβ42/Aβ40, p-tau217, p-tau181, GFAP, and NfL) from six different assay platf.....

onlinelibrary.wiley.com

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Meredith Braskie @meredithbraskie.bsky.social · Jul 8

🧠New paper alert!
We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️
675 adults:
• AB+ cognitively impaired (CI)
• AB– cognitively unimpaired (CU)
• 28% Hispanic, 31% NH Black, 41% NH White
🔗 Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social

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Reposted by Meredith Braskie

Imaging Neuroscience @imagingneurosci.bsky.social · Jun 23

New paper in Imaging Neuroscience by Victoria R. Tennant, Meredith N. Braskie, et al:

Establishing tau-PET cut-points for cognitive diagnosis with 18F-PI-2620 in a multi-ethnoracial cohort

doi.org/10.1162/IMAG...

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Meredith Braskie @meredithbraskie.bsky.social · Jun 30

📣Our new paper, led by @victoriatennant.bsky.social, sets tau cut points in a large cohort of Hispanic, and non-Hispanic Black and White participants using PI-2620 PET.
⭐️The ability of our tau cut points to distinguish cognitively impaired vs unimpaired people varied by ethnoracial group.

USC INI @uscini.bsky.social · Jun 30

🚨 We've identified a new brain imaging benchmark that may improve how researchers classify biologically meaningful changes associated with Alzheimer’s disease 🧠
Learn more & check out the animation! bit.ly/45JfzER

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Meredith Braskie @meredithbraskie.bsky.social · Jun 26

👋Welcome to Patrick Walsh, who has joined our lab as a full time Project Assistant! Patrick has an MS in Neuroimaging and Informatics from USC (NIIN). He will be working on projects whose goal is to better understand risk for Alzheimer's disease and related dementias 🧠

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Meredith Braskie @meredithbraskie.bsky.social · Jun 11

📣Our paper (bit.ly/3ZndVVh), led by PhD student, Amaryllis Tsiknia, links diabetes to cortical thickness in 2171 Hispanic & non-Hispanic Black and White cognitively unimpaired older adults 🧠🥮
We found that:

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Meredith Braskie @meredithbraskie.bsky.social · Jun 5

In this new paper, led by Dr. Allie Clark:
-People with low resources & high distress had smaller hippocampi & thinner cortex in AD-relevant regions compared with people having more resources and less distress.
-Low resources (regardless of distress) were associated with accelerate brain aging.

Alexandra L. Clark @alexleighclark.bsky.social · May 23

📣 New paper out discussing brain age gap & neurostructural patterns across our psychosocial behavioral phenotypes in HABS-HD: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS‐HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness

INTRODUCTION This study examined whether previously identified psychosocial behavioral phenotypes differed on structural neuroimaging markers. METHODS Latent profile analysis (LPA) employed in a s.....

alz-journals.onlinelibrary.wiley.com

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Meredith Braskie @meredithbraskie.bsky.social · Jun 4

🎉Congrats to Noelle Lee, who will start a software development engineer internship this summer! Noelle has been with the lab 4 years and her amazingly analytical mind, careful work, and fun personality made the lab a better place 🌟🧠.
We miss you already, Noelle!

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Meredith Braskie @meredithbraskie.bsky.social · May 27

📣 New paper led by Dr. Dillys Lui in Dr. Kristine Yaffe's lab: bit.ly/3HeZFb1
-⬆️ light sleep% & longer REM sleep latency = thinner cortex in Alzheimer's disease-related regions
-⬆️ deep sleep % = thicker cortex (same regions)
-⬆️ apnea hypopnea index in rapid eye movement sleep = ⬆️ WMH volume.

Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer's disease‐related MRI patterns among diverse older adults

INTRODUCTION Sleep patterns change with aging, yet their relationship with brain health, particularly Alzheimer's disease (AD)-related MRI patterns among diverse older adults is not clear. METHODS...

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Meredith Braskie @meredithbraskie.bsky.social · May 17

🎓 Another year with our terrific USC MS in Neuroimaging and Informatics program students draws to an end 🧠💻.
Congrats NIIN graduates! So proud of you 🎉!

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Meredith Braskie @meredithbraskie.bsky.social · May 15

🎉Congrats to PhD student, Amaryllis Tsiknia, who led our new paper bit.ly/3ZndVVh studying how diabetes relates to cortical thickness in Hispanic & non-Hispanic Black & White older adults!

Read more here: bit.ly/3GS0Ddj
More on our findings soon...

USC INI @uscini.bsky.social · May 15

🧠 Our new study finds a strong link between type 2 diabetes and brain atrophy in older adults—especially in memory-related regions. Managing blood sugar could be key to protecting brain health as we age.
Learn more 👉 bit.ly/3GS0Ddj

USC Study Reveals Link Between Type 2 Diabetes and Brain Health in Older Adults from Various Populations

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