MetaStem
@metastem.bsky.social
68 followers
120 following
19 posts
Centre of Excellence in Stem Cell Metabolism at University of Helsinki. Funded by Research Council of Finland, Suomen Akatemia. www.helsinki.fi/metastem
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MetaStem
@metastem.bsky.social
· Jul 28
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
MetaStem
@metastem.bsky.social
· Jul 28
Stem-cell-derived beta cells mature metabolically upon murine engraftment - Diabetologia
Aims/hypothesis The use of stem-cell-derived islets (SC-islets) as a source for cell-based therapy of type 1 diabetes shows great potential. However, SC-islets have a metabolically immature phenotype ...
link.springer.com
Reposted by MetaStem
KatajistoLab
@katajistolab.bsky.social
· Jul 14
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
MetaStem
@metastem.bsky.social
· May 22
Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism - Acta Neuropathologica Communications
Dominant defects in CHCHD10, a mitochondrial intermembrane space protein, lead to a range of neurological and muscle disease phenotypes including amyotrophic lateral sclerosis. Many patients present w...
actaneurocomms.biomedcentral.com
Reposted by MetaStem
KatajistoLab
@katajistolab.bsky.social
· Apr 28
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
MetaStem
@metastem.bsky.social
· Apr 28
Organelle age guides tissue renewal through subcellular compartmentalization of metabolism | Faculty of Biological and Environmental Sciences | University of Helsinki
A new study sheds light on the mechanisms that regulate how our tissues develop and are constantly renewed to keep up their function. In the future, these results might contribute to the understanding...
www.helsinki.fi
MetaStem
@metastem.bsky.social
· Apr 28
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
nature.com
Reposted by MetaStem
KatajistoLab
@katajistolab.bsky.social
· Apr 28
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
Reposted by MetaStem
Rafa Najumudeen
@rafabolism.bsky.social
· Apr 28
MetaStem
@metastem.bsky.social
· Apr 17
Reposted by MetaStem
Reposted by MetaStem
