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MICROB-PREDICT @microb-predict.bsky.social · 15d

🔬 Read the original publication by Boglarka Balogh, David Tornai, Aniko Csillag et al. (2025) on behalf of the MICROB-PREDICT consortium and the PREDICT study group of the EASL-CLIF consortium: onlinelibrary.wiley.com/doi/10.1111/...

Secretory IgA Is a Key Marker Among Gut Barrier Dysfunction‐Related Immunoglobulins Predicting Outcomes in ACLF

Background and Aims In cirrhosis, impaired gut mucosal immunity facilitates bacterial translocation (BT) instigating the proinflammatory cascade that exacerbates hepatic damage. The role of antibody...

onlinelibrary.wiley.com

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MICROB-PREDICT @microb-predict.bsky.social · 15d

🚨 New #LiverFailure insights 🚨

In patients with #cirrhosis + acute #decompensation, secretory #IgA strongly correlates with #gut-barrier failure and is a powerful predictor of 90-day mortality in acute-on-chronic #LiverFailure #ACLF

👉 Watch on YouTube: youtu.be/KapUqG7AFFk

#Biomarkers #GutBarrier

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MICROB-PREDICT @microb-predict.bsky.social · Aug 27

Both groups (placebo vs. #albumin treatment) are monitored closely regarding their liver disease & overall health. We thank the dedicated teams at all sites across Europe for their hard work in achieving this milestone. We look forward to continuing this progress toward completing the ALB-TRIAL! 💪

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MICROB-PREDICT @microb-predict.bsky.social · Aug 27

The ALB-TRIAL is a double-blinded, placebo-controlled clinical trial to see if a new biomarker can be used to predict which patients with #cirrhosis + #ascites benefit most from long-term human #albumin infusion. Moving towards personalised treatment, less complications & lower risk of death. 🔬⚕️🩺

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MICROB-PREDICT @microb-predict.bsky.social · Aug 27

👏 ALB-TRIAL hits 50% enrollment 🎉

Half of the planned 240 patients have now been recruited across 14 centres in 7 countries - great progress for the MICROB-PREDICT project!

Huge thanks to all site teams - Onward to full enrollment & better treatment for #cirrhosis patients with #ascites!
#albumin

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Reposted by MICROB-PREDICT

A-TANGO Project @a-tango.bsky.social · May 28

Join this exciting event!

Don't miss our #OpenInnovation event, uniting experts in #DrugDevelopment, #bioinformatics, and #hepatology. Connect with researchers, industry professionals, and investors to share insights & explore collaboration opportunities!

🚀 Register now: inevent.uk/en/Crowdheli...

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Reposted by MICROB-PREDICT

A-TANGO Project @a-tango.bsky.social · May 10

🧪 SAT-209 – #EASL2025
MNK6106 vs. rifaximin to treat #HepaticEncephalopathy - new Phase 2a data from Prof. @rajivjalan.bsky.social (UCL) explores safety, PK & ammonia-lowering potential. HE treatment innovation in motion! #Cirrhosis

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Reposted by MICROB-PREDICT

A-TANGO Project @a-tango.bsky.social · May 10

🧠 SAT-210 – #EASL2025

New tool alert!

The #mHEST scale brings clarity to grading hepatic #encephalopathy in trials & clinics. A big step for #cirrhosis care. Kudos to Prof. @rajivjalan.bsky.social & his team!

#LiverHealth #HE #ClinicalResearch

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MICROB-PREDICT @microb-predict.bsky.social · May 10

🔬 Improving the prognostic performance of the #MELD score is a challenge that Nikolaj Torp (Odense University Hospital) took on, comparing the original score with MELD 3.0 in 777 patients with an acute #decompensation of #cirrhosis

#POSTER SAT-196-YI 👏

📅 Presented at #EASLCongress | #EASL2025

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Reposted by MICROB-PREDICT

concentris research management gmbh @concentris.bsky.social · May 10

✨ #PosterTour today at #EASLCongress 2025:
All our 3 Horizon2020 #LiverResearch projects in 1 session!

Topic: #Cirrhosis & #PortalHypertension
Chair: Maria Papp

💡 Big moments:

#AMMON-OHE model for post-#TIPS #encephalopathy (Rajiv Jalan)

#Terlipressin response in AKI-HRS w/ CKD (Frank Uschner)

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MICROB-PREDICT @microb-predict.bsky.social · May 10

@easlnews.bsky.social

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MICROB-PREDICT @microb-predict.bsky.social · May 10

One last time #LIVE from the #EASLStudio: Tot Ziens Amsterdam, Hola Barcelona! 👋

As #EASL2025 draws to a close, Debbie Shawcross and Aleksander Krag reflect on the highlights from Amsterdam and set the stage for #EASL2026 in Barcelona.

Thank you for an inspiring #EASLCongress - see you next year!

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MICROB-PREDICT @microb-predict.bsky.social · May 10

🧪 Mads Israelsen (Odense Universitetshospital – Svendborg Sygehus) leads together with Alberto Zanetto the YI #Workshop on How to prepare a #Clinical #Practice #Guideline in Hepatology, offering valuable insights for young investigators.

📅 Presented at the #EASLCongress | #EASL2025

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MICROB-PREDICT @microb-predict.bsky.social · May 10

One last time at #EASL2025: Wim Laleman (KUL) hosts the EASL/CIRSE Skills Learning Centre session on #Liver #Haemodynamics, providing hands-on learning in liver disease management.

🕙 10:15 – 11:15, Skills Learning Centre 2
@easlnews.bsky.social @cirsesociety.bsky.social

MICROB-PREDICT @microb-predict.bsky.social · May 8

🔬 EASL/CIRSE Skills Learning Centre: Liver Haemodynamics
Join Wim Laleman (KUL) for an in-depth session on Liver Haemodynamics
📅 Presented at the #EASLCongress | #EASL2025
🕙 10:00 – 11:00
Also available at 12:30, 14:00, and 16:15!

@easlnews.bsky.social @cirsesociety.bsky.social

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MICROB-PREDICT @microb-predict.bsky.social · May 10

Live from the #EASLCongress: Debbie Shawcross (KCL) presents on Rebooting immunity: Harnessing FMT to revive innate defences in #cirrhosis as part of the Symposium “Microbiome and liver health: Unveiling new therapeutic pathways” 🦠🧫

#EASL2025 @easlnews.bsky.social
@kingscollegelondon.bsky.social

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MICROB-PREDICT @microb-predict.bsky.social · May 10

Join us at the Industry Room: Evolving concepts in MASLD, ALD & MetALD at #EASLCongress

Learn about:
✏️ New terminology & pathophysiology
🔬Non-invasive tools for diagnosis, prognosis & monitoring

🚨 Stay updated on the latest in metabolic & alcohol-related liver disease!

#MASLD #MetALD

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MICROB-PREDICT @microb-predict.bsky.social · May 9

👏 What an accomplishment 🥳

Frederike Krus selected for this afternoon's #PosterTour at #EASLCongress

👉 POSTER ID FRI-175

Loss of hepatic #leptin clearance is associated with the development of #ACLF, acute-on-chronic #LiverFailure

📍 #Cirrhosis & Complications
📅 Fri, 9 May

@medblab.bsky.social

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Reposted by MICROB-PREDICT

Med B Research Lab @ University of Münster @medblab.bsky.social · May 9

Prof. JonelTrebicka presents and discusses the development and success of #TIPS over the past 25 years, high above the rooftops of #Amsterdam.

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Reposted by MICROB-PREDICT

Med B Research Lab @ University of Münster @medblab.bsky.social · May 7

We are ready for #EASLCongress. We are happy to welcome you at our Posters.

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MICROB-PREDICT @microb-predict.bsky.social · May 9

Breaking Barriers 🩺: Novel insights in today's evening Abstract Session on #Alcohol 🍷 at #EASLCongress (Alcohol-related #LiverDisease), co-chaired by Elisa Pose from MICROB-PREDICT partner Fundació Clínic per a la Recerca Biomèdica, FCRB, in Barcelona.

@easlnews.bsky.social
@europeliver.bsky.social

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MICROB-PREDICT @microb-predict.bsky.social · May 9

🩺 #POSTER FRI-226 by Wenyi Gu (@medblab.bsky.social at the Universitätsklinikum Münster #UKM) presents her newest results on the burden & impact of #extrahepatic organ failures in European patients with #cirrhosis.

📅 Presented at #EASLCongress | #EASL2025, up until 17h, still time to swing by ☺️

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MICROB-PREDICT @microb-predict.bsky.social · May 9

🌟 Rising star - first big conference for him, so give him an applause 👏!

Hendrik Rogge presents a great #poster today at #EASLCongress about the 📊 prediction of circulatory failure in intensive-care #patients with liver #cirrhosis & #ACLF.

👉 #POSTER FRI-182, up until 17h

@medblab.bsky.social

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MICROB-PREDICT @microb-predict.bsky.social · May 9

🔬 Maximilian Brol's #POSTER FRI-493

👉 Conversion from standard-release to prolonged-release tacrolimus mitigates #calcineurin-induced #nephrotoxicity in patients after #LiverTransplantation

The poster is still up until 17:00 today ☺️

📅 Presented at #EASLCongress 2025
@medblab.bsky.social

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MICROB-PREDICT @microb-predict.bsky.social · May 9

🔬👩‍🔬 Big news: Loss of hepatic #leptin clearance is associated with the development of acute-on-chronic liver failure #ACLF

#POSTER FRI-175 by Frederike Krus (Universität Münster,
@medblab.bsky.social) - don’t miss it, up until 17h today!

📅 Presented at #EASLCongress 2025

#LiverFailure #cirrhosis

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MICROB-PREDICT @microb-predict.bsky.social · May 9

🎥 LIVE from the #EASLStudio at #EASL2025!
@debbieshawcross.bsky.social (KCL) leads today’s deep dive into “Moving towards recompensation: Putting out the fire that fuels decompensation and ACLF” - tackling the key drivers of decompensation and ACLF, from systemic inflammation to portal hypertension.

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