Lightnews — Scholar-powered news

Mike Lange @mikelangelipid.bsky.social · Aug 30

Fantastic! Congratulations Gunes!!!

Reposted by Mike Lange

James Olzmann @olzmannlab.bsky.social · Aug 6

Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis

Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

www.biorxiv.org

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Reposted by Mike Lange

James Olzmann @olzmannlab.bsky.social · Jul 20

The count down has begun! 1-week until the 1st FASEB Ferroptosis conference! Looking forward to seeing everyone at the meeting. Get excited!! 🤩
events.faseb.org/event/11797f...

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Reposted by Mike Lange

Jesse Garcia Castillo, PhD @jgcastillo.bsky.social · Jul 10

My third paper from grad school is out on Biorxiv! This was a fun collaboration with @olzmannlab.bsky.social where we show that Ferroptosis Suppressor Protein-1 is a better target than GPX4 because it disrupts Treg function while leaving effector T cell function intact.

bioRxiv Immunology @biorxiv-immuno.bsky.social · Jul 10

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity https://www.biorxiv.org/content/10.1101/2025.07.06.663397v1

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Reposted by Mike Lange

James Olzmann @olzmannlab.bsky.social · Jul 11

New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity

A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...

www.biorxiv.org

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Reposted by Mike Lange

James Olzmann @olzmannlab.bsky.social · Jun 3

FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...

Home - Ferroptosis, Oxidative Stress, and Lipid Metabolism

events.faseb.org

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Mike Lange @mikelangelipid.bsky.social · May 29

Yes!

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Reposted by Mike Lange

Pavel Barahtjan @pavelbarahtjan.bsky.social · May 29

The world is small... Randomly found out that @mikelangelipid.bsky.social and I are both in Osaka, so we met up for some drinks and #lipidtime talk.

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Mike Lange @mikelangelipid.bsky.social · May 29

It was fun hanging out! Come again!

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Mike Lange @mikelangelipid.bsky.social · May 8

It's out! Amazing! Congratulations!!!!

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Mike Lange @mikelangelipid.bsky.social · May 8

this is such a fantastic paper! Congrats to all these exciting findings!

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Reposted by Mike Lange

Ubellacker Lab @ubellackerlab.bsky.social · May 7

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

Barbara Marte @barbmarte.bsky.social · May 7

new out in Nature, very cool story www.nature.com/articles/s41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

www.nature.com

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Reposted by Mike Lange

James Olzmann @olzmannlab.bsky.social · May 7

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Lipid-degrading small molecule kills cancer cells by ferroptosis

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

www.nature.com

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Mike Lange @mikelangelipid.bsky.social · May 8

Here is the exciting original publication: www.nature.com/articles/s41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

www.nature.com

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Mike Lange @mikelangelipid.bsky.social · May 8

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

Lipid-degrading small molecule kills cancer cells by ferroptosis

A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

shorturl.at

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Reposted by Mike Lange

Dr. Dawn Wright @deepseadawn.bsky.social · May 3

**Rapid Response Bridge Funding Program** -- $25,000 grants earmarked for early-career researchers whose NSF-funded research on STEM and education has just been terminated.

www.spencer.org/grant_types/...

hub.jhu.edu/2025/04/28/j...

Thanks @lizneeley.bsky.social !

Rapid Response Bridge Funding Program

In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...

www.spencer.org

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Mike Lange @mikelangelipid.bsky.social · May 4

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

James Olzmann @olzmannlab.bsky.social · May 3

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1

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Reposted by Mike Lange

West Coast Metabolomics Center UCDavis @metabolomics-wcmc.bsky.social · Apr 30

Join us next week: Bits and Bites on May 8, from 9-1pm, on Zoom. Registration and payment here: na.eventscloud.com/ereg/index.p... We will present and discuss the best practice for #Quality Control and Quality Assurance. #metabolomics #NMR #GC-MS #LC-MS @mikelangelipid.bsky.social @crick.ac.uk

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Mike Lange @mikelangelipid.bsky.social · Mar 28

Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform

Aakriti Jain @aakritijain.bsky.social · Mar 27

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org

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Reposted by Mike Lange

The Lancet @thelancet.com · Feb 7

“...to care is an act not of weakness, but of strength.”

The Lancet response: bit.ly/4jRb5Av

A Lancet Editorial: “American chaos: standing up for health and medicine”

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Reposted by Mike Lange

Andrew Perfors @andyperfors.bsky.social · Feb 4

RIP any human subjects methods section: women, gender, female, excluded

RIP math/stats: biases, marginalise, equality, inequality, group, inclusive

RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural

This is not just evil it is also SO VERY DUMB

Darby Saxbe @darbysaxbe.bsky.social · Feb 4

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

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Reposted by Mike Lange

Darby Saxbe @darbysaxbe.bsky.social · Feb 4

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

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Reposted by Mike Lange

Meng-meng Fu @mengmengfu.bsky.social · Jan 24

If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.

I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!

Pls repost 🙏❤️

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Mike Lange @mikelangelipid.bsky.social · Jan 14

Amazing review! Congrats to all authors!!

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Reposted by Mike Lange

James Olzmann @olzmannlab.bsky.social · Jan 8

Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

www.biorxiv.org

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