5/5
🏺 This matters because alternate peptide sequences can lead to inaccurate protein taxonomy and archaeological interpretations. The Demodifier is fast and open source, enabling easy detection of MISPs.
📄 Paper: doi.org/10.1371/jour...
💻 GitHub: github.com/miranda-e/De...

4/5
📊 The Demodifier was applied to a test dataset including 20 published studies of dental calculus and vessel residues, revealing that modification-induced sequence permutations occurred almost ten times more frequently than previously reported.

3/5
💻 The Demodifier simulates all possible modification-induced sequence permutations caused by deamidation (NQ) and N-terminal pyroglutamic acid formation, and assigns lowest common taxonomic ancestors via the Unipept API.

2/5🧵
🧪 Protein modifications such as deamidation and N-terminal pyroglutamic acid formation can change peptide sequences and affect taxonomic assignment in palaeoproteomics.

1/5🧵
🚨 New open access paper out today🚨
The Demodifier: a tool for screening modification-induced alternate peptide taxonomy in palaeoproteomics.
doi.org/10.1371/jour...
#palaeoproteomics

2/5
🧪 Protein modifications such as deamidation and N-terminal pyroglutamic acid formation can change peptide sequences and affect taxonomic assignment in palaeoproteomics.

Please join us online or in person for this term's Garrod Seminar Series 'Consumed by time: Past foodways in practice' @cam-archaeology.bsky.social.
We are delighted to have an amazing line up of experts in their field speaking. More details here: talks.cam.ac.uk/show/index/1...

Thank you! I love making posters. The skull is a flap, which reveals CT scans when raised.

Having a blast at BABAO! @babao2025meeting.bsky.social
Thanks everyone who came and saw our poster "The Curious case of the Candia skull: demography revealed by minimally invasive methods" @drtrishbiers.bsky.social

Delighted to report that my manuscript "The Demodifier: a tool for screening modification-induced alternate peptide taxonomy in palaeoproteomics" has been recommended by PCI.

The Demodifier, an open source tool, screens for inaccurate taxonomic matches caused by PTMs www.biorxiv.org/content/10.1...

Thank you @isba11.bsky.social for a fantastic conference!!! I can't wait to find out where the next one is.
And thank you to everyone who came to my talk "The Demodifier: a tool for screening modification-induced alternate peptide taxonomy in ancient protein studies".

Apparently I talk with my hands. Thanks for having me to present on "The Proteomics of Pottery: what can dirty dishes tell us about ancient diet and cuisine?" at the Pudding Seminar, @Newnham_College!