Khalimonchuk Lab
@mitocrue.bsky.social
980 followers
500 following
52 posts
Semper vestigans | All things mitochondria
https://biochem.unl.edu/oleh-khalimonchuk-lab/
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Khalimonchuk Lab
@mitocrue.bsky.social
· Aug 28
Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting - Nature Structural & Molecular Biology
Yang et al. uncover the molecular details of how mitochondrial proteins cross the outer and inner mitochondrial membranes, with hydrophobicity guiding them into distinct pathways toward specific desti...
www.nature.com
Khalimonchuk Lab
@mitocrue.bsky.social
· Aug 27
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation
Localized translation broadly enables spatiotemporal control of gene expression. Here, we present LOV-domain-controlled ligase for translation localiz…
www.sciencedirect.com
Khalimonchuk Lab
@mitocrue.bsky.social
· Jul 10
Khalimonchuk Lab
@mitocrue.bsky.social
· Jun 26
Interaction with AK2A links AIFM1 to cellular energy metabolism
AIFM1 is crucial for mitochondrial function. Here, Rothemann, Pavlenko et al. show
that AK2A interacts with NADH-dependent AIFM1 dimers. They demonstrate that this interaction
stabilizes AIFM1 dimers ...
www.cell.com
Khalimonchuk Lab
@mitocrue.bsky.social
· Jun 23
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology
Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...
www.nature.com
Khalimonchuk Lab
@mitocrue.bsky.social
· Jun 16
Structural mechanism of mitochondrial membrane remodelling by human OPA1 - Nature
Human OPA1 embeds itself into cardiolipin-containing membranes through a lipid-binding paddle domain, and OPA1 oligomerization through multiple assembly interfaces promotes the helical assembly of a f...
www.nature.com
Khalimonchuk Lab
@mitocrue.bsky.social
· May 24
Mechanistic insights into Bcs1-mediated mitochondrial membrane translocation of the folded Rieske protein | The EMBO Journal
imageimageBcs1 is an unusual, heptameric AAA-ATPase that translocates its cargo, Rip1, across
the inner mitochondrial membrane in a fully folded state. Cryo-EM and functional data
provide novel insigh...
www.embopress.org
Reposted by Khalimonchuk Lab
Science Magazine
@science.org
· May 23
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...
scim.ag
Reposted by Khalimonchuk Lab
Kondadi Lab
@kondadilab.bsky.social
· May 21
Khalimonchuk Lab
@mitocrue.bsky.social
· May 15
Molecular machineries shaping the mitochondrial inner membrane - Nature Reviews Molecular Cell Biology
The inner mitochondrial membrane forms cristae, which are crucial for mitochondrial function. This Review explores the protein complexes that regulate cristae dynamics, including remodelling and fusio...
www.nature.com
Reposted by Khalimonchuk Lab
Khalimonchuk Lab
@mitocrue.bsky.social
· Apr 25
Structures of human organellar SPFH protein complexes
Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) family proteins are found in all kingdoms of life and in multiple eukaryotic organelles. SPFH proteins assemble into homo- or hetero-oligomeric rings...
www.biorxiv.org
Khalimonchuk Lab
@mitocrue.bsky.social
· Mar 30
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses
Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...
www.science.org
Khalimonchuk Lab
@mitocrue.bsky.social
· Mar 26
Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
www.nature.com
Khalimonchuk Lab
@mitocrue.bsky.social
· Mar 22
In situ architecture of the human prohibitin complex - Nature Cell Biology
Lange, Ratz, et al. investigate the number and distribution of human prohibitin complexes in the mitochondrial inner membrane, uncovering their bell-shaped structure and assembly of alternating PHB1 a...
www.nature.com
Khalimonchuk Lab
@mitocrue.bsky.social
· Mar 21
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
Khalimonchuk Lab
@mitocrue.bsky.social
· Mar 13
Structure of human PINK1 at a mitochondrial TOM-VDAC array
Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson’s Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determi...
www.science.org
Khalimonchuk Lab
@mitocrue.bsky.social
· Mar 11
Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins
Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...
www.biorxiv.org