Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arrest and block phage dissemination.

Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...

RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage...

Cryptic splicing has emerged as a pervasive feature of mammalian gene expression, with recent studies uncovering thousands of previously unannotated splice sites. Despite its prevalence, the functional...

To understand the relative contributions of 5ʹ UTR elements to translation output, we performed a comprehensive analysis of upstream open reading fram…

Abstract. Accurate protein synthesis requires ribosomes to integrate signals from distant functional sites and execute complex dynamics. Despite advances i

Lamb et al. show that the circadian clock rhythmically remodels ribosome composition in Neurospora crassa. Clock-regulated incorporation of the ribosomal protein eL31 is required for rhythmic translation and translation fidelity, linking temporal ribosome remodeling to daily changes in proteome diversity.