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Reposted by Monika Wolkers

Matthias Eberl @eberlmat.bsky.social · 7d

Somehow we don't talk about this enough.

Matthias Eberl @eberlmat.bsky.social · 9d

"Nigel meets tens of thousands of people on an annual basis."

Just amazing then how many of them are called Nathan Gill.

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Monika Wolkers @monikawolkers.bsky.social · 14d

Can we do the same with Farage please? Wilders? (who got a lot of platform by the journalists which in fact made him big... ) At least no more front page headlines. no place for lies there. Lets learn from this.

Monika Wolkers @monikawolkers.bsky.social · 14d

First cats in the US, and now Swans in the UK?! how absurd can it get...

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Monika Wolkers @monikawolkers.bsky.social · 17d

love it!

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Monika Wolkers @monikawolkers.bsky.social · Sep 3

our study on #gdTcells in pediatric neuroblastoma is out! In contrast to adult tumors, it is the gdTcells that not only expand, but that are the most tumor reactive #TILs.

#immunology #tumorimmunology

funded by KIKA, Sanquin and supported by Oncode

www.life-science-alliance.org/content/8/11...

γδ T cells are the prime antitumoral T cells in pediatric neuroblastoma

High-risk pediatric neuroblastoma patients have a dismal survival rate despite intensive treatment regimens. New treatment options are thus required. Even though HLA expression in neuroblastoma is low...

www.life-science-alliance.org

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Monika Wolkers @monikawolkers.bsky.social · Sep 3

our study on #gdTcells in pediatric neuroblastoma is now out in

Reposted by Monika Wolkers

DonnaDee 💙 @overallthiscrap.bsky.social · Aug 30

Unvaccinated citizens in the 50s

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Reposted by Monika Wolkers

Olga Nesterova @onestpress.onestnetwork.com · Aug 18

Kharkiv right now. Moscovia bombs sleeping families. 4 victims including kids.

Don’t tell me about peace that Putin wants. Do not dare.

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Reposted by Monika Wolkers

Ben Nicolet @bnicolet.bsky.social · Aug 1

Can you boost the protein expression in specific cell types?
That is what we asked in our study published a week ago in @scienceadvances
We used machine learning (AI) to learn the code for protein expression in immune cells.

www.science.org/doi/10.1126/...

Learning the sequence code of protein expression in human immune cells

SONAR informs the design of cell type–specific protein expression in human cells.

www.science.org

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Monika Wolkers @monikawolkers.bsky.social · Jul 29

#Tcells #RBPs #generegulation preprint

www.biorxiv.org/content/10.1...

Proximity labeling reveals ZFP36L1 as a central hub for post-transcriptional regulation networks in T cells

Effective T cell responses against pathogens require a rapid yet tightly controlled remodeling of the proteome, and RNA binding proteins (RBPs) are key in this process. For instance, the RBP ZFP36L1 p...

www.biorxiv.org

Monika Wolkers @monikawolkers.bsky.social · Jul 29

👇New preprint:
Proximity labeling in human T cells uncovers ZFP36L1 as central hub for post-transcriptional gene regulation.
We found known and unknown ZFP36L1 interactors, their interaction dynamics and RNA (in)dependency, elucidating ZFP36L1's multifaceted role.

www.biorxiv.org/content/10.1...

Proximity labeling reveals ZFP36L1 as a central hub for post-transcriptional regulation networks in T cells

Effective T cell responses against pathogens require a rapid yet tightly controlled remodeling of the proteome, and RNA binding proteins (RBPs) are key in this process. For instance, the RBP ZFP36L1 p...

www.biorxiv.org

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Monika Wolkers @monikawolkers.bsky.social · Jul 23

Great work spearheaded by Ben @bnicolet.bsky.social

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Monika Wolkers @monikawolkers.bsky.social · Jul 23

We used information on conservation, length, codon usage, miRNA and RNA Binding Protein and putative Post-translational modificationmotifs +more. Together #RNA abundance, we could predict protein abundance AND modulate protein expression with synthetic 3'UTRs, exemplified in #Tcells

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Monika Wolkers @monikawolkers.bsky.social · Jul 23

it is finally out! 👇 our #ML pipeline SONAR, which can predict the protein abundance in #immune cells. Using sequence features present in the #RNA. With @bnicolet.bsky.social

Supported by the @erc.europa.eu [email protected]

www.science.org/doi/epdf/10....

Learning the sequence code of protein expression in human immune cells

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www.science.org

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Monika Wolkers @monikawolkers.bsky.social · Jul 17

super proud of Kaspar for receiving the VENI grant from NWO-ZonMW. And I am very excited to see what he will find!
www.linkedin.com/posts/sanqui...

🎉 Kaspar Bresser, who works at Sanquin in Monika Wolkers' group and at Amsterdam UMC, has been awarded a Veni grant from the NWO (Dutch Research Council) for his research into how T cells develop…...

🎉 Kaspar Bresser, who works at Sanquin in Monika Wolkers' group and at Amsterdam UMC, has been awarded a Veni grant from the NWO (Dutch Research Council) for his research into how T cells develop ...

www.linkedin.com

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Reposted by Monika Wolkers

Insta Science @instascience.bsky.social · Jul 6

When birds saw humans give an injured bird special treatment.😅

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Monika Wolkers @monikawolkers.bsky.social · Jul 7

you are unlucky Thiago, if you stay until Thursday, Summer will have returned again... 🌞

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Monika Wolkers @monikawolkers.bsky.social · Jul 7

Bekijk Stop de asielwetten op groenlinkspvda.nl/petitie/stop...

Teken de petitie: Stop de asielwetten | GroenLinks-PvdA

Stop de asielwetten! Deze wetten van het kabinet Wilders-Yesilgöz zijn asociaal, onverantwoord en onmenselijk. Teken de petitie en hou ze tegen.

groenlinkspvda.nl

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Monika Wolkers @monikawolkers.bsky.social · Jul 1

congrats Nadine! indeed fantastic.

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Monika Wolkers @monikawolkers.bsky.social · May 25

both of them did great! thanks for the wonderful interactions!!!

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Reposted by Monika Wolkers

Payal Yokota @payalyokota.bsky.social · May 23

The unparalleled @bsilvasantos.bsky.social concludes the amazing #gammadeltatoronto with the keynote talk. A moment I've waited for since may2022 inaugural #gdtcellclub talk.

Super excited to see the wrap up for the unbelievable conf thanks to JC and the other fellow organizers.

Let's go!!

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Reposted by Monika Wolkers

Joachim Goedhart @joachimgoedhart.bsky.social · May 12

Job opportunity at our institute at the University of Amsterdam:
www.academictransfer.com/en/jobs/3519...

Assistant Professor Computational Analysis of Single-cell and Spatial Omics Data

Are you passionate about developing omics data analysis methodology? Are you fascinated by the opportunities of omics data at single-cell or spatial resolution? Would you like to work at the forefront...

www.academictransfer.com

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Monika Wolkers @monikawolkers.bsky.social · May 10

Got the same comment. And yet - here I am. It is not always easy, but this holds for any major changes in life. It is definitely possible and doable and absolutely not a hurdle when you wish to be a PI. I certainly would not have wanted it any other way! #happyMothersDay

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Monika Wolkers @monikawolkers.bsky.social · May 3

👇super nice work on TCR-pMHC prediction by the Schumacher lab. Congrats!

Schumacher Lab @schumacher-lab.bsky.social · May 2

It's not the models, it's the data!

We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.

www.biorxiv.org/content/10.1...

A functionally validated TCR-pMHC database for TCR specificity model development

Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...

www.biorxiv.org

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Monika Wolkers @monikawolkers.bsky.social · Apr 29

happy #dayofimmunology! It also happens to be my birthday and guess what my profession is - could not be better fitting, no?!

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