Payal Yokota
@payalyokota.bsky.social
2.2K followers
1.1K following
360 posts
Postdoc, Immunologist, #GdTcellclub webinar series (founder/organizer)
#TrainedImmunity #TissueResMacrophages #DiseaseTolerance
payalyokota.com
#immunosky
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Payal Yokota
@payalyokota.bsky.social
· Apr 25
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
Payal Yokota
@payalyokota.bsky.social
· Sep 8
Hematopoietic stem and progenitor cells as a reservoir for trained immunity
Inflammation supports selection, differentiation bias, and epigenetic reprogramming of hematopoietic stem and progenitor cells to generate innate immune memory.
elifesciences.org
Payal Yokota
@payalyokota.bsky.social
· Sep 2
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
www.nature.com
Payal Yokota
@payalyokota.bsky.social
· Aug 29
The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology
Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...
www.nature.com