Multi-omics integration reveals risk-associated gene expression signatures, identifying CD52 as a potential therapeutic target for high-risk JMML.

Anti-CD52 treatment depletes JMML stem cells and disrupts disease propagation in a JMML PDX model.

RAS-pathway mutations induce fetal-like gene expression programs in a JMML mouse model, suggesting RAS-driven oncofetal reprogramming in murine JMML stem cells.

Fetal HSC signatures are enriched in patients without detectable JMML driver mutations at birth.

JMML stem cells show transcriptional plasticity, hijacking parts of distinct developmental programs, including fetal HSC marker genes, leading to mosaic-like developmental expression programs.

This suggests the reactivation rather than preservation of oncofetal signatures.

The postnatal maturation state of JMML stem cells challenges the universality of the maturation block model in pediatric malignancies.

JMML epitypes are prognostic biomarkers in JMML.

Conservation of such disease-specific epigenetic signatures in HSC-like JMML stem cells and downstream immune cells suggests HSCs or early HSPCs as the cells-of-origin in JMML across JMML epitypes.

Epigenomes encode cell type, developmental state, and disease-specific information.

DNA methylomes of JMML stem cells reveal:

1. HSC-like cell type signatures
2. A postnatal maturation state
3. Disease-specific epitypes

ONLINE FIRST ALERT!

Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

aacrjournals.org/bloodcancerd...

@aacrjournals.bsky.social

#childhoodcancer
#epigenetics
#precisiononcology

No #nobelpize @bsky.app !?

@nobelprize.bsky.social is an empty desert… Pity!

#science #research

Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics.

#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science

Summer Selection of the International #PhD Program at the German Cancer Research Center (@dkfz.bsky.social)

Apply here: t1p.de/amwgq

#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky

Actually, not so rare at all!

#RareDiseaseDay

Affecting a substantial part of human kind!

Support research on rare diseases!

Picture from rarediseaseday.org

What a fantastic meeting! Thrilled to welcome Frank Westermann, Katrin Ottersbach, and Jan-Henning Klusmann to the @dkfz.bsky.social to dive into the developmental origins of #ChildhoodCancers.

Excited to announce the upcoming 80th Heidelberg Grand Round on

"Developmental Signatures and Molecular Plasticity in Cancer"!

Heidelberg, on Nov 14, 2024, from 4:00-6:00 PM.

Explore #Cancer as a developmental disease!

@dkfz.bsky.social
NCT Heidelberg
Universitätsklinikum Heidelberg

Exciting insights by Andi Roy into the role of the fetal HSPC marker LIN28B on human lymphopoiesis and infant ALL at the EMBO Workshop Intercepting Childhood Blood Cancer in Düsseldorf.

#ChildhoodCancer
#bloodsky

Great talk from @laurenmharmon.bsky.social from @timtriche.bsky.social lab about germline variant burden in pediatric AML.

#bloodsky

Today is #internationalchildhoodcancerday! 🎗️

Picture from KITZ - Hopp Children‘s Cancer Center Heidelberg

Do you think fetal transcription signatures are the consequence of a maturation block of a prenatal cell-of-origin in #childhoodcancer ?

This might not always be true!

Evidence for #oncofetal #reprogramming can be found in our new preprint @dblipka.bsky.social

www.biorxiv.org/content/10.1...