Mark Hartmann
@mphartmann.bsky.social
Scientist at DKFZ and NCT Heidelberg
#epigenetics #stemcells #leukemia #colorectalcancer #multiomics #precisiononcology
#oncofetal #reprogramming
#plasticity
www.translational-cancer-epigenomics.de
#epigenetics #stemcells #leukemia #colorectalcancer #multiomics #precisiononcology
#oncofetal #reprogramming
#plasticity
www.translational-cancer-epigenomics.de
Pinned
Mark Hartmann
@mphartmann.bsky.social
· Dec 6
ONLINE FIRST ALERT!
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Reposted by Mark Hartmann
🚨We have an opening for Data Scientists or Bioinformaticians using machine learning and AI with all kinds of molecular data to support cancer research. 🧬
Permanent position, fantastic team, exciting projects—what more could you ask for?
www.lih.lu/en/job/?valu...
Permanent position, fantastic team, exciting projects—what more could you ask for?
www.lih.lu/en/job/?valu...
Job » Luxembourg Institute of Health
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website via the apply button below.
www.lih.lu
January 15, 2026 at 10:36 AM
🚨We have an opening for Data Scientists or Bioinformaticians using machine learning and AI with all kinds of molecular data to support cancer research. 🧬
Permanent position, fantastic team, exciting projects—what more could you ask for?
www.lih.lu/en/job/?valu...
Permanent position, fantastic team, exciting projects—what more could you ask for?
www.lih.lu/en/job/?valu...
Reposted by Mark Hartmann
Out in print this week @bloodjournal.bsky.social . Very proud of this collaborative work with Prof Karadimitris @imperialimmuno.bsky.social. Thanks to @cancerresearchuk.org and CwC_UK for funding this work. #InfantALL @paediatrics.ox.ac.uk @imm.ox.ac.uk
Off-the-shelf bispecific CD133-CD19 CAR-iNKT cells eradicate CAR antigen–high and –low medullary and leptomeningeal KMT2Ar ALL. Read in Blood: buff.ly/HIlsUq7 #ALL #BloodJournal
January 12, 2026 at 6:09 PM
Out in print this week @bloodjournal.bsky.social . Very proud of this collaborative work with Prof Karadimitris @imperialimmuno.bsky.social. Thanks to @cancerresearchuk.org and CwC_UK for funding this work. #InfantALL @paediatrics.ox.ac.uk @imm.ox.ac.uk
Frühkindliche Leukämie: Zellen reaktivieren fetale Programme
Forschende am Nationalen Centrum für Tumorerkrankungen (NCT) Heidelberg und am Deutschen Krebsforschungszentrum (DKFZ) haben neue Erkenntnisse gewonnen, wie eine bestimmte frühkin...
weiterlesen
Forschende am Nationalen Centrum für Tumorerkrankungen (NCT) Heidelberg und am Deutschen Krebsforschungszentrum (DKFZ) haben neue Erkenntnisse gewonnen, wie eine bestimmte frühkin...
weiterlesen
January 8, 2026 at 4:11 PM
Interesting story about the role of #oncofetal RNA-binding proteins in #immune #evasion in #ovarian #cancer.
Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer
doi.org
January 8, 2026 at 1:14 PM
Interesting story about the role of #oncofetal RNA-binding proteins in #immune #evasion in #ovarian #cancer.
Reposted by Mark Hartmann
Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org
January 7, 2026 at 3:53 PM
Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!
Reposted by Mark Hartmann
Neue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie.
www.nct-heidelberg.de/das-nct/news...
@dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
www.nct-heidelberg.de/das-nct/news...
@dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
December 15, 2025 at 1:48 PM
Neue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie.
www.nct-heidelberg.de/das-nct/news...
@dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
www.nct-heidelberg.de/das-nct/news...
@dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
ONLINE FIRST ALERT!
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
December 6, 2025 at 12:59 AM
ONLINE FIRST ALERT!
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Looks awesome!
🧬 CellWhisperer introduces a chat-based way to explore scRNA-seq data. By enabling natural language analysis, it bridges biologists and bioinformaticians—paving the way for AI-driven bioinformatics assistants. (10/11)
November 12, 2025 at 1:18 PM
Looks awesome!
Pipeline Olympics for DNA methylation data
Check this out:
doi.org/10.1093/nar/...
Important study from @rn-toth.bsky.social & @pavlolutsik.bsky.social
Published @narjournal.bsky.social
#epigenetics
#methylation
#bioinformatics
Check this out:
doi.org/10.1093/nar/...
Important study from @rn-toth.bsky.social & @pavlolutsik.bsky.social
Published @narjournal.bsky.social
#epigenetics
#methylation
#bioinformatics
Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold standard
Abstract. DNA methylation is a widely studied epigenetic mark and a powerful biomarker of cell type, age, environmental exposures, and disease. Whole-genom
doi.org
October 21, 2025 at 11:42 PM
Pipeline Olympics for DNA methylation data
Check this out:
doi.org/10.1093/nar/...
Important study from @rn-toth.bsky.social & @pavlolutsik.bsky.social
Published @narjournal.bsky.social
#epigenetics
#methylation
#bioinformatics
Check this out:
doi.org/10.1093/nar/...
Important study from @rn-toth.bsky.social & @pavlolutsik.bsky.social
Published @narjournal.bsky.social
#epigenetics
#methylation
#bioinformatics
October 7, 2025 at 8:26 PM
scEpi2-seq: a method for simultaneous single-cell profiling of DNA methylation and histone modifications.
@jervdberg.bsky.social @hubrechtinstitute.bsky.social
www.nature.com/articles/s41...
@jervdberg.bsky.social @hubrechtinstitute.bsky.social
www.nature.com/articles/s41...
Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance - Nature Methods
This work presents scEpi2-seq, a method for simultaneous single-cell profiling of DNA methylation and histone modifications, enabling direct investigation of the interplay between these two epigenomic marks.
www.nature.com
October 1, 2025 at 12:09 PM
Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics.
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
September 26, 2025 at 4:17 PM
Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics.
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science
The German Science and Humanities Council declares permanent positions the new standard.
Interview with @wickwolfgang.bsky.social & Insa Großkraumbach
@wissenschaftsrat.de
A must-read for all working in higher education and research in Germany!
#Wissenschaft
#Forschung
#WissZeitVG
#IchBinHanna
Interview with @wickwolfgang.bsky.social & Insa Großkraumbach
@wissenschaftsrat.de
A must-read for all working in higher education and research in Germany!
#Wissenschaft
#Forschung
#WissZeitVG
#IchBinHanna
Schluss mit "Up or Out"
Der Wissenschaftsrat erklärt Dauerstellen zum Regelfall. Ein Paukenschlag vor der Novelle des Wissenschaftszeitvertragsgesetzes. Im Interview erklären Wolfgang Wick und Insa Großkraumbach, was das bedeutet.
Im Wiarda-Blog: www.jmwiarda.de/blog/2025/07...
Der Wissenschaftsrat erklärt Dauerstellen zum Regelfall. Ein Paukenschlag vor der Novelle des Wissenschaftszeitvertragsgesetzes. Im Interview erklären Wolfgang Wick und Insa Großkraumbach, was das bedeutet.
Im Wiarda-Blog: www.jmwiarda.de/blog/2025/07...
July 17, 2025 at 12:11 PM
The German Science and Humanities Council declares permanent positions the new standard.
Interview with @wickwolfgang.bsky.social & Insa Großkraumbach
@wissenschaftsrat.de
A must-read for all working in higher education and research in Germany!
#Wissenschaft
#Forschung
#WissZeitVG
#IchBinHanna
Interview with @wickwolfgang.bsky.social & Insa Großkraumbach
@wissenschaftsrat.de
A must-read for all working in higher education and research in Germany!
#Wissenschaft
#Forschung
#WissZeitVG
#IchBinHanna
Der @wissenschaftsrat.de fordert einen Kulturwandel im Wissenschaftssystem: moderne Personalstrukturen, attraktive Karrierewege, mehr Dauerstellen. Ein längst überfälliger und wichtiger Schritt.
www.wissenschaftsrat.de/SharedDocs/P...
#Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik
www.wissenschaftsrat.de/SharedDocs/P...
#Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik
Pressemitteilungen - Die Wissenschaft braucht moderne Personalstrukturen und mehr Dauerstellen | WR gibt Anstoß für einen Kulturwandel
Der Wissenschaftsrat (WR) fordert eine grundlegende Reform der Personalstrukturen im deutschen Wissenschaftssystem. Das Ziel sind attraktive, vielfältige Stellen mit klar strukturierten Entwicklungsoptionen, die die Wissenschaftseinrichtungen in der Konkurrenz um Fachkräfte sowie im internationalen Wettbewerb stärken. Nötig ist ein Personalgefüge, das den immer stärker ausdifferenzierten Anforderungen an die und aus der Wissenschaft gerecht wird und attraktive Dauerstellen ergänzend zur Professur bietet.
www.wissenschaftsrat.de
July 17, 2025 at 11:43 AM
Der @wissenschaftsrat.de fordert einen Kulturwandel im Wissenschaftssystem: moderne Personalstrukturen, attraktive Karrierewege, mehr Dauerstellen. Ein längst überfälliger und wichtiger Schritt.
www.wissenschaftsrat.de/SharedDocs/P...
#Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik
www.wissenschaftsrat.de/SharedDocs/P...
#Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik
Fascinating!
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
April 13, 2025 at 8:10 AM
Fascinating!
Reposted by Mark Hartmann
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
April 6, 2025 at 9:45 AM
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
Congratulations, Muzz!
The most deserving winner of the 2025 Tickle Medal is Muzlifah Haniffa!
bsdb.org/2025/03/24/2...
bsdb.org/2025/03/24/2...
March 25, 2025 at 6:55 AM
Congratulations, Muzz!
Summer Selection of the International #PhD Program at the German Cancer Research Center (@dkfz.bsky.social)
Apply here: t1p.de/amwgq
#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky
Apply here: t1p.de/amwgq
#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky
March 19, 2025 at 2:12 PM
Summer Selection of the International #PhD Program at the German Cancer Research Center (@dkfz.bsky.social)
Apply here: t1p.de/amwgq
#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky
Apply here: t1p.de/amwgq
#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky
Reposted by Mark Hartmann
🦎 Differential expression analysis relies on cluster identities, unless you perform a regression along continuous representation in latent space. LEMUR from @const-ae.bsky.social & @wkhuber.bsky.social does that neatly for scRNA-seq data!
🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social
🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social
Analysis of multi-condition single-cell data with latent embedding multivariate regression
Nature Genetics - Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction...
doi.org
March 19, 2025 at 7:44 AM
🦎 Differential expression analysis relies on cluster identities, unless you perform a regression along continuous representation in latent space. LEMUR from @const-ae.bsky.social & @wkhuber.bsky.social does that neatly for scRNA-seq data!
🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social
🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social
Amazing collection of reviews on developmental hematopoiesis from leaders in the field. Just out in @iseh.bsky.social journal, Experimental Hematology www.exphem.org/content/edit...
Editorial_Making_blood_Early_Hematopoietic_Development
www.exphem.org
March 12, 2025 at 8:25 PM
Reposted by Mark Hartmann
Outstanding contributions to our field and society acknowledged with this year’s ISEH awards. Presentations and award seminars at this year’s annual meeting in Kumamoto iseh.org/page/iseh2025
March 11, 2025 at 3:52 PM
Outstanding contributions to our field and society acknowledged with this year’s ISEH awards. Presentations and award seminars at this year’s annual meeting in Kumamoto iseh.org/page/iseh2025
Actually, not so rare at all!
#RareDiseaseDay
Affecting a substantial part of human kind!
Support research on rare diseases!
Picture from rarediseaseday.org
#RareDiseaseDay
Affecting a substantial part of human kind!
Support research on rare diseases!
Picture from rarediseaseday.org
February 28, 2025 at 7:27 PM
Actually, not so rare at all!
#RareDiseaseDay
Affecting a substantial part of human kind!
Support research on rare diseases!
Picture from rarediseaseday.org
#RareDiseaseDay
Affecting a substantial part of human kind!
Support research on rare diseases!
Picture from rarediseaseday.org
Reposted by Mark Hartmann
To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪
Rare Disease Day 2025: Paediatric Leukaemias
YouTube video by MRC Weatherall Institute of Molecular Medicine
youtu.be
February 28, 2025 at 10:28 AM
To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪
Reposted by Mark Hartmann
🔥 New Fraticelli lab publication🔥
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
February 25, 2025 at 4:24 PM
🔥 New Fraticelli lab publication🔥
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.
Performed with the support of Cris Cancer and @erc.europa.eu
#InternationalChildhoodCancerDay
Support medical care and biomedical research for our vulnerable children worldwide!
#Science
#CancerResearch
#ChildhoodCancer
#OncoSky
#Kinderkrebstag
Support medical care and biomedical research for our vulnerable children worldwide!
#Science
#CancerResearch
#ChildhoodCancer
#OncoSky
#Kinderkrebstag
Today is #internationalchildhoodcancerday! 🎗️
Picture from KITZ - Hopp Children‘s Cancer Center Heidelberg
Picture from KITZ - Hopp Children‘s Cancer Center Heidelberg
February 14, 2025 at 7:26 PM
#InternationalChildhoodCancerDay
Support medical care and biomedical research for our vulnerable children worldwide!
#Science
#CancerResearch
#ChildhoodCancer
#OncoSky
#Kinderkrebstag
Support medical care and biomedical research for our vulnerable children worldwide!
#Science
#CancerResearch
#ChildhoodCancer
#OncoSky
#Kinderkrebstag