banner
mruwolt.bsky.social
Max Ruwolt
@mruwolt.bsky.social
64 followers 130 following 4 posts
Staff Scientist in Mass spectrometry platform @fmp-berlin.de‬. Interested in cross-linking mass spectrometry and interactomics.
Posts Media Videos Starter Packs
mruwolt.bsky.social
Max Ruwolt @mruwolt.bsky.social · 21d
Big congrats to my colleagues upstairs! Great work now published in @natchem.nature.com. Always happy to run #proteomics experiments with you. 🤝
vincearafiles.bsky.social
Vince Arafiles @vincearafiles.bsky.social · 21d
🔥After years of hard work, it's finally out in @natchem.nature.com🔥 The Hackenberger group @fmp-berlin.de developed #🎯DarT-labeling, a #photocatalyticproximitylabeling method using deazaflavin - a ✅ biocompatible ✅ easily synthesized ✅ chemically benign #photocatalyst

www.nature.com/articles/s41...
Energy-transfer photoproximity labelling in live cells using an organic cofactor - Nature Chemistry
Current photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofa...
www.nature.com
1 3
Reposted by Max Ruwolt
pastelbio.bsky.social
PastelBio @pastelbio.bsky.social · Aug 27
AIRPred: A Deep Learning Model Predictor for Peptide Intensity Ratios in Cross-Linking Mass Spectrometry Improves Cross-Link Spectrum Matching pubs.acs.org/doi/10....

---
#proteomics #prot-paper
2
mruwolt.bsky.social
Max Ruwolt @mruwolt.bsky.social · Aug 20
Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation.

www.nature.com/articles/s41...
Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation - Nature Chemistry
Our understanding of how post-translational modification—protein phosphorylation—impacts the complexity of eukaryotic signalling pathways is continuously expanding. Now, protein oligophosphorylation h...
www.nature.com
2 9
mruwolt.bsky.social
Max Ruwolt @mruwolt.bsky.social · Aug 20
Thank you @nesvilab.bsky.social, it indeed became an invaluable tool throughout this and other projects that we're working on.
1 1
mruwolt.bsky.social
Max Ruwolt @mruwolt.bsky.social · Aug 5
A fun little side project from our FMP MS platform just got published! Previously, we struggled with messy Excel sheets to monitor machine performance and allocate machine time to users. Now, Q2C combines those management tasks into one user-friendly, GUI-based software. 💻
pastelbio.bsky.social
PastelBio @pastelbio.bsky.social · Aug 3
Q2C: A software for managing mass spectrometry facilities www.sciencedirect.co...

---
#proteomics #prot-paper
3
Reposted by Max Ruwolt
bogdanow.bsky.social
Boris Bogdanow @bogdanow.bsky.social · Jul 22
Check out Structural Host–Virus Interactome Profiling (SHVIP) in intact cells infected with Herpes Simplex Virus type 1 (HSV-1)! Now published!

📄 www.nature.com/articles/s41...
#LoveVirology #TeamMassSpec
Structural host-virus interactome profiling of intact infected cells - Nature Communications
Virus-host protein-protein interactions are fundamental to viral pathogenesis, yet few are structurally resolved. Here, the authors combine cross-linking mass spectrometry, bio-orthogonal labeling and...
www.nature.com
1 2 5