Thank you @chemkritzer.bsky.social ! We hope that these findings would be of great help to #cellpenetratingpeptides community. Stay tuned for the next stories soon!

Thank you! 🙏🏾We are hoping that this could be useful for the #chemicalbiology community

(con'd) This work is only possible with the lead and good friend #LeanderCrocker, #JudithMüchler, @mruwolt.bsky.social, @cestieger.bsky.social, and our great collaborators from @uniregensburg.bsky.social , Nataliya Archipowa and Roger-Jan Kutta

(con'd) which suggest the participation of exocytosis pathways. #DarT-labeling🎯 provides an evidence to this long theorized phenomenon!

(con'd) More importantly, owing to the high #biocompatibility of #DarT-labeling🎯, we could monitor the fate of undegraded penetrating peptides #CPPs after prolonged incubation. The change of protein interactome of the undegraded CPPs from nuclear proteins to exosome proteins and lysosomal proteins

In this work, we showed the capabilities of DarT by mapping the cell-surface #proteome of HeLa cells and putative #intracellular interactome of #CellPenetratingPeptides!

🔥After years of hard work, it's finally out in @natchem.nature.com🔥 The Hackenberger group @fmp-berlin.de developed #🎯DarT-labeling, a #photocatalyticproximitylabeling method using deazaflavin - a ✅ biocompatible ✅ easily synthesized ✅ chemically benign #photocatalyst

www.nature.com/articles/s41...

I am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS).

www.nature.com/articles/s41...

New from our group: proline-rich peptides that target mitochondria & stay there!
Tuning hydrophobicity and rigidity provided design rules for CPPs that enter cells and redistribute for long-term mitochondrial residency.
Now out in ACS Chemical Biology: pubs.acs.org/doi/10.1021/...

Another beautiful cover image by @barthvanrossum.bsky.social highlighting both our recent BioRAM intracellular delivery platform together and the CPP-additive technology is now an Outside Back Cover in @angewandtechemie.bsky.social ! @fmp-berlin.de

onlinelibrary.wiley.com/doi/10.1002/...

@angewandtechemie.bsky.social @jacs.acspublications.org

#BioRAM works hand-in-hand with our developed #CPPadditives. Check out the prequel paper here: doi.org/10.1021/jacs...

#BioRAM is the new #celldelivery platform in town! Everyone can now access the full version of this game-changing work from Jonathan Franke! Ecstatic to share my experience in #peptide - based #proteindelivery #intracellulardelivery @fmp-berlin.de @humboldt-foundation.de

doi.org/10.1002/anie...

Sent! It's done! Can't wait to see our work in print 😌 #photoproximity #proteomics #cellpenetratingpeptides

Also check out the associated News & Views by Masayasu Taki and Masayoshi Nakamura highlighting the work from @kjohnsson.bsky.social lab on SNAP-tag2

www.nature.com/articles/s41...

Beautiful work by the @matilegroup.bsky.social! I'm following their thiol-mediated uptake stories and feel happy that #photocatalyticproximitylabeling is opening new doors to discover the mechanism of this fascinating cellular entry mechanism! #drugdelivery #cellularuptake

Excited to see this beautiful cover art by @barthvanrossum.bsky.social, which clearly illustrates our new bioconjugation chemistry for precise antibody modification in @jacs.acspublications.org! A big thank you to all co-authors @fmp-berlin.de & Tubulis GmbH and @humboldt-foundation.de for funding!

Huge development to protein delivery platforms from the Hackenberger lab in @fmp-berlin.de! An awesome collaboration with #JonathanFranke to get this science out in @angewandtechemie.bsky.social

BioReversible Arginine Modification (BioRAM) on Amino Groups onlinelibrary.wiley.com/doi/10.1002/...

Great and meticulous work by my colleagues @mar_degeus @PhosphorusFive @fmp-berlin.de Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

Transgenic means that genes from 1 organism have been put into another. We make transgenic mice to understand how genes influence biological processes. We make transgenic plants to make them more nutrient rich. We make transgenic bacteria so they make medicine for us. It's wide-ranging & v. useful.

Beyond excited to announce our in-person symposium to celebrate the 25th anniversary of ChemBioChem/ChemPhysChem!

Advances in Structural Analysis of Biomolecules
From Subcellular Imaging to Drug Design

October 23-24, 2025, Berlin

Please like and share: cbc-cpc2025.org

Very much looking forward to the 25th anniversary symposium of ChemBioChem and ChemPhysChem #CBCCPC2025 in Berlin on October 23rd and 24th, 2025.

There is an ever growing list of amazing speakers confirmed for this event. (1/2)

#chemsky #ChemBio @chemistryeurope.bsky.social

www.cbc-cpc2025.org