Lightnews — Scholar-powered news

Roman-Ulrich Müller @muellerrom.bsky.social · 23d

Transition of patients with hereditary nephropathies from pediatric to adult care url: academic.oup.com/ndt/article-...

Transition…such an important topic for improving patient care…but still underrepresented in care pathways.

Transition of patients with hereditary nephropathies from pediatric to adult care

Abstract. Adolescents and young adults with chronic kidney disease (CKD), particularly those with genetic kidney diseases, face unique challenges as they t

academic.oup.com

4

Reposted by Roman-Ulrich Müller

markusathome @markusathome.bsky.social · 26d

Tonight it's all about ADPKD!

KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller

youtu.be/qjnYDsYbx0Q?...

@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

ADPKD: KDIGO GL / ERA Genes & Kidney WG - Prof. Roser Torra, Prof. Roman-Ulrich Müller

YouTube video by MARKUS at HOMe

youtu.be

4 9

Reposted by Roman-Ulrich Müller

Cologne Graduate School of Ageing Research @cga-age.bsky.social · Aug 22

📹 Interested in a PhD position in aging research starting in 2026? Then watch our new short video for some tips from our wonderful PhD students and faculty.
Don't miss the deadline: November 3, 2025.
Apply now and start your journey with us!

8 9

Reposted by Roman-Ulrich Müller

markusathome @markusathome.bsky.social · Aug 19

KDIGO 2025 ADPKD Guideline: A commentary on diagnosis and management of hepatopancreatic manifestations by the ERA Working Group Genes & Kidney by Drs. @muellerrom.bsky.social , @joostphdrenth.bsky.social, et al.

academic.oup.com/ndt/article/...

2 2

Roman-Ulrich Müller @muellerrom.bsky.social · Aug 14

The KDIGO ADPKD Guideline is a milestone for the field.

Building upon this work, experts assembled by the ERA Working Group Genes&Kidney now provide additional practical guidance for polycystic liver disease in #ADPKD.

academic.oup.com/ndt/article/...

@ecorneclegall.bsky.social

KDIGO 2025 ADPKD Guideline: A commentary on diagnosis and management of hepatopancreatic manifestations by the ERA Working Group Genes & Kidney

Abstract. The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal

academic.oup.com

2

Roman-Ulrich Müller @muellerrom.bsky.social · Aug 13

CKDx: Simplicity matters, implementation is key url: academic.oup.com/ndt/article/...

At this stage, it is all about widespread adoption of a simple concept: we do not always know the diagnosis in kidney disease. And reporting diagnostic steps in a simple manner enables us to go the next step.

CKDx: Simplicity matters, implementation is key

Emilie Cornec-Le Gall, Jan Halbritter, Roman Ulrich Müller; CKDx: Simplicity matters, implementation is key, Nephrology Dialysis Transplantation, , gfaf137

academic.oup.com

Reposted by Roman-Ulrich Müller

Cologne Graduate School of Ageing Research @cga-age.bsky.social · Aug 12

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!

22 16

Roman-Ulrich Müller @muellerrom.bsky.social · Aug 8

Obtaining a thorough family history is so important in kidney disease....but often more difficult than expected in clinical practice...

10 tips on how to take a proper family history in CKD patient care url: academic.oup.com/ckj/article/...

10 tips on how to take a proper family history in CKD patient care

Abstract. Patients with chronic kidney disease (CKD) often present with a family burden of disease. However, efficient collection and documentation of fami

academic.oup.com

3 5

Roman-Ulrich Müller @muellerrom.bsky.social · Aug 6

Happy to share the nice video @unicologne.bsky.social has produced on our recent publication identifying novel protein biomarkers for #ADPKD.
www.youtube.com/watch?v=FDGN...
rdcu.be/ezvN4
@cecad.bsky.social @uniklinikkoeln.bsky.social

Nierenerkrankungen anhand von Bluttest vorhersagen // Wissenschaftsnachrichtenvideo

YouTube video by UniversitaetzuKoeln

www.youtube.com

2 4

Roman-Ulrich Müller @muellerrom.bsky.social · Aug 4

Absolutely. But still no funding to implement these spectacular findings…😉 I guess this will be a long learning process for policymakers…

Reposted by Roman-Ulrich Müller

CECAD Cologne @cecad.bsky.social · Aug 1

What happens when #mitochondria fail in high-energy tissues? Cells adjust their metabolism and alter the mechanics of the nucleus! Read more on the discovery by Dr. Harshita Kaul from the Trifunovic Lab in Nature Metabolism.

➡️ uni.koeln/QZURH

#CellStress #NatureMetabolism @unicologne.bsky.social

Beyond classic stress signalling: how mitochondrial stress softens the cell nucleus and alters cellular identity

A University of Cologne research team has discovered that cells in high-energy-demanding tissues respond to mitochondrial dysfunction in a surprising way. Instead of shutting down, cells adjust their ...

uni.koeln

1 3 5

Reposted by Roman-Ulrich Müller

Healthcare in Europe (DE) @health-europe-de.bsky.social · Jul 31

Mithilfe von #Massenspektrometrie ist es einem Team um @muellerrom.bsky.social ‪vom @cecad.bsky.social an der @unicologne.bsky.social ‪und der @uniklinikkoeln.bsky.social ‪ gelungen, den Verlauf von Erkrankungen der #Nieren anhand einer Blutprobe deutlich genauer vorherzusagen als bisher möglich.

Bluttest sagt voraus, wie schnell Nieren ihre Funktion einstellen

Ein Forschungsteam der Universität zu Köln hat einen neuartigen Ansatz entwickelt, um anhand von Blutproben vorherzusagen, wie schnell eine Nierenerkrankung fortschreiten wird.

healthcare-in-europe.com

1 2

Reposted by Roman-Ulrich Müller

PKD International @pkdinternational.bsky.social · Jul 29

KDIGO ADPKD Guideline: A Milestone in Genetic Kidney Diseases Why is a global guideline for ADPKD so important?

Prof. Roman Müller explains how the new KDIGO guideline marks a crucial step forward in harmonizing care for patients with #ADPKD) worldwide 👇

2 5

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 23

Great thanks to Jörg Bernards-Stiftung and @dfg.de (Excellence Strategy @cecad.bsky.social) for supporting this work and to all patients participating.

Universität zu Köln @unicologne.bsky.social · Jul 23

Predicting kidney disease trajectories with a simple blood test🩸
A research team around @muellerrom.bsky.social has developed a new approach to predict the progression of kidney disease via 29 proteins in the blood that are associated with the decline of kidney function.
▶️https://uni.koeln/3U6M5

Predicting kidney disease trajectories with a simple blood test

A University of Cologne research team has developed a novel approach to predict how fast kidney disease is likely to progress, using just blood samples. They discovered 29 proteins that are linked to ...

uni.koeln

2 6

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 23

Interested in a postdoctoral fellowship on polycystic kidney disease? Linking molecular data with outcome? Please get in touch.

euraxess.ec.europa.eu/jobs/hosting...

MSCA PF 2025 UzK Hosting Offer - The impact of kidney disease on well-being - a translational approach (Roman Müller Lab)

euraxess.ec.europa.eu

2

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 22

Untargeted. Targeted assays for absolute quantification in a prospective study will now have to be the next step towards implementation

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

📎 Read the full study here: Nature Commun. 16, 6646 (2025) – DOI 10.1038/s41467-025-61887-8

1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

10/ This work was enabled by all patients participating and central support by the Jörg Bernards-Stiftung and @DFG through the Excellence Initiative (@CECAD). Thank you!
@cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social and Center for Molecular Medicine Cologne

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

9/ Next steps:
• Develop targeted assays for the 6 proteins
• Prospective multicenter validation
• Explore integration with other data layers (e.g. metabolomics) and treatment response
• Ultimate goal: precision-medicine profiling for ADPKD care rdcu.be/exbNq

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

8/ Why it matters:
✅ Blood-based protein markers are inexpensive and accessible
✅ They improve prediction where MRI and genetics may fall short
✅ Pave the way for targeted assays (e.g. ELISA, mass spec) and prospective clinical use rdcu.be/exbNq

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

7/ Notably, the proteome data adds predictive information independent of eGFR at baseline. In ROC analysis for identifying rapid progressors (>3 ml/min/yr) adding the protein to MIC enhanced the AUC rdcu.be/exbNq

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

6/ These models were cross-validated in two large cohorts: an internal cohort (Cologne) and an external cohort using EDTA plasma instead of serum (Groningen). rdcu.be/exbNq

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

5/ The model based on these 6 proteins was superior to a clinical standard model based on eGFR and Mayo Imaging Class (MIC). Adding the proteins to the clinical standard further improved the model. rdcu.be/exbNq

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

4/ Using weighted LASSO, we narrowed it to 6 key proteins:
• GPX3 (oxidative stress)
• SERPINF1 (angiogenesis regulator)
• AFM (vitamin E transport)
• FERMT3 (cell adhesion)
• CFHR1 (complement pathway)
• RARRES2 (inflammation/adipogenesis) rdcu.be/exbNq

1 1

Roman-Ulrich Müller @muellerrom.bsky.social · Jul 21

3/ We analyzed serum from large cohorts via semi-automated mass spectrometry. Identified 29 proteins significantly linked to yearly eGFR decline rdcu.be/exbNq

1 1